Topic B1 - laminitis

Question 1

What type of performance horse usually get

laminitis?

Answer 1

Dressage

Question 2

What are the 2 main causes of laminitis?

Answer 2

1. Carb overload
2. Obesity/ EMS/ PPID and insulin resistance
   (and laminitis)

Question 3

What is carb overload also known as?

Answer 3

Pasture associated laminitis

Grass founder

Question 4

Aetiology of carb overload

Answer 4

Starch/ fructose i.e oligofructose- alters the
microbial flora- incr lactic acid production- decr
in the intraluminal pH– incr intestinal
permeability and osmotic P which leads to entry
of:
1. endo and exotoxins
2. vasoactive amines
3. bact by products
The 3 of these cause a systemic inflamm
response– insulin resistance— LAMINITIS!!

Question 5

Aetiology of Obesity + EMS + PPID and insulin

resistance

Answer 5

Obesity: proinflamm state- TNF alpha secreted
by adipose
Insulin: VasoC. incr adhesion molecules on
endothel– migration of Ne to the laminar tissues
Platelet activation by biogenic amines and
intestinal endotoxins

Question 6

What is insulin resistance

Answer 6

When the normal amount of insulin is unable to
remove glucose from the blood and into :
muscle, fat, liver. The pancreas secretes more
insulin to compensate- this causes
hyperinsulinaemia

Question 7

Causes of hyperinsulinaemia/ Insulin resistance

Answer 7

1. PPID
2. Corticosteroids
3. Genetic
4. Obesity
5. Lack of exercise
6. High ESC/NSC and starch diet