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Flashcards in TORCH Infections Deck (30)
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1
Q

What are some sx of Toxoplasmosis

A
Intracerebral calcifications (centre), hydrocephalus, chorioretinitis (TRIAD)
(also microcephaly)
2
Q

What is the exposure that causes toxoplasmosis?

A

Cat Litter

3
Q

What are the clinical manifestations of CMV exposure in utero

A

Mental Retardation, cerebral palsy, periventricular calcification, hearing impairment, eye abnormalities (chorioretinitis), hepatosplenomegaly, thrombocytopenia purpura

4
Q

When in gestation do teratogens affect the fetus (Torch etc)

A

3 - 8 weeks

5
Q

Which anticonvulsant is most toxic to fetus

A

Valproic acid

6
Q

Where are brain calcifications in CMV

A

periventricular (unique for CMV)

7
Q

Where are brain calcifications in Toxoplasmosis

A

intraventricular. therefore obstructing flow of csf therefore hydrocephalus

8
Q

what percent of cmv congenital is asymptomatic at birth

A

90%

9
Q

Torch infections cause what type of IUGR

A

symmetrical

10
Q

how do you test for congenital CMV?

A

CMV antigen in urine

11
Q

what kind of hearing loss is associated with CMV?

A

sensorineural hearing loss

12
Q

What are infantile symptoms of congenital syphillis

A

rash, osteochondritis, periostitis, lung & liver fibrosis

13
Q

What are childhood symptoms of congenital syphillis

A

Hutchinsons teeth

14
Q

What are the early congenital syphillis signs

A

Early rhinitis (3rd - 8 week OL), rash, IUGR, hepatosplenomegaly

15
Q

How do you prevent syphillis?

A

prenatal screening

16
Q

What is the drug of choice for syphillis?

A

Penicillin

17
Q

What is the classic triad of congenital rubella?

A

cataracts, cardiac abnormalities, deafness

18
Q

how do you prevent congenital rubella?

A

mom had MMR vaccine

19
Q

How do neonates get HSV ?

A

Most likely form is peripartum (85%), Postnatal (10%), in utero (5%)

20
Q

how do you recognize HSV?

A

vesicles

21
Q

When does disseminated HSV happen?

A

unwell at 5 - 11 DOL

22
Q

What are symptoms of disseminated HSV?

A

similar to bacterial sepsis, with hyper or hypothermia, irritability, poor feeding, and vomiting

23
Q

How often are skin vesicles seen in disseminated HSV?

A

75% of cases

24
Q

What are you thinking in a newborn with purulent eye discharge? (neonatal conjunctivitis)

A

Gonorrhea/ Chlamydia

25
Q

What does gonorrhoea gram stain as?

A

Gram -ve diplococci

26
Q

Does chalmydia gran stain?

A

No

27
Q

What is the tx for gonorrhea

A

ceftriaxone

28
Q

what is the tx for chlamydia

A

erythromycin (oral)

29
Q

What is dacrocystitis?

A

requires optho consult, infection of tear duct

30
Q

A 38 week gestation male infant was precipitously delivered vaginally. Weight and head circumference are less than 5th percentile, and length at 10th percentile. He has heptosplenomegaly and petechial rash. Platelets of 22,000 and elevated total and direct bilirubin levels. CT of the head shows bilaterals intracranial calcification with several around the basal ganglia and obstructive hydrocephalus.

Ophthamologic examination reveals chorioretinits. What is the most likely cause of the patient’s findings?

CMV
Rubella 
Toxoplasmosis gondii
Herpes simplex 
Treponema pallidum
A

Toxoplasmosis