Tournament 3

Question 1

Part of the gastrointestinal tract which serves as a reserve area for the absorption of drugs that have escaped absorption proximally because of their physicochemical properties or their dosage form

Answer 1

LARGE INTESTINE

Question 2

___________ delivery systems place the drug at or near the receptor site

Answer 2

TARGETED

Question 3

This is the formation of a ring-like structure resulting from the interaction between a partial ring of atoms and a metal

Answer 3

CHELATION

Question 4

The extent of ionization may be described by

Answer 4

HENDERSON-HASSELBALCH EQUATION

Question 5

Part of the transdermal drug delivery system that maintains the drug concentration gradient within the device

Answer 5

ADHESIVE LAYER

*formulation matrix

Question 6

The faster the stomach emptying the

Answer 6

higher the plasma drug concentration

Question 7

Which of the following gives the correct order of decreasing rate of absorption?

Answer 7

SOLUTION, SUSPENSION, CAPSULE, TABLET

Question 8

Lying on the left side _________ rate of gastric emptying

Answer 8

DECREASES

Question 9

The _________ of a single dose of a drug is a function of both the rate and extent of absorption

Answer 9

EFFICACY

Question 10

Capsule shells become brittle at low ______

Answer 10

HUMIDITY

Question 11

In modified release dosage forms, this is the rate-limiting step

Answer 11

LIBERATION

Question 12

The in vitro correlate of drug absorption that indicates the time it takes for a solid dosage form to breakdown into small particles, not necessarily solution

Answer 12

DISINTEGRATION

Question 13

Modified release tablets alter the __________ of drug release

Answer 13

RATE OR TIMING

Question 14

For hydrophobic drugs, excessive particle size reduction does not always lead to faster dissolution rate due to formation of

Answer 14

AGGREGATES

Question 15

In ________, the drug is impregnated into a biodegradable or nonbiodegradable material and is released slowly for localized or systemic effect

Answer 15

INSOLUBLE MATRICES

Question 16

Generally, drug-cyclodextrin complexes

Answer 16

ARE MORE WATER SOLUBLE

Question 17

Particle size is __________ related to surface area

Answer 17

INVERSELY

Question 18

Drug dissolution is described by

Answer 18

NOYES-WHITNEY EQUATION

Question 19

This is the ability of a drug to exist in more than one crystalline form

Answer 19

POLYMORPHISM

Question 20

Transport process which is also described as “cell-eating”

Answer 20

PHAGOCYTOSIS

Question 21

This excipient makes powders adhere to each other and form aggregates

Answer 21

BINDER

Question 22

The rate of gastric emptying is the rate-limiting step in the dosage form

Answer 22

SOLUTION

Question 23

The more complication the formulation of a drug product, the greater the potential for __________ problems

Answer 23

BIOAVAILABILITY

Question 24

Usually the _____ form dissolves more rapidly than the hydrated form

Answer 24

ANHYDROUS

Question 25

In conventional oral dosage forms, this is the rate-limiting step

Answer 25

DISSOLUTION

Question 26

The make segments of the gastrointestinal tract differ from one another both anatomically and _____, as well as with respect to secretions and ph

Answer 26

MORPHOLOGICALLY

Question 27

Modified release tablets may sometimes result to ______ problem

Answer 27

DOSE-DUMPING

Question 28

This part of the gastrointestinal tract is where substance like alcohol, barbital, and aspirin are readily absorbed

Answer 28

STOMACH

Question 29

Transport process where drugs are moved by the aid of ATP-dependent pumps

Answer 29

TRANSPORTER PROTEINS

Question 30

Transdermal drug delivery systems contain the drug for _______ absorption after topical application to the skin

Answer 30

SYSTEMIC

Question 31

This is the ration of drug solubility (at equilibrium) in non-aqueous and aqueous solvent

Answer 31

PARTITION COEFFICIENT

Question 32

Better blood supply favors a/an

Answer 32

INCREASE IN ABSORPTION OF THE DRUG

Question 33

Tablets have reduced effective area due to _________

Answer 33

COMPRESSION

Question 34

An increase in the temperature of food __________ rate of gastric emptying

Answer 34

INCREASES

Question 35

Part of the gastrointestinal tract where the epithelial surface area is extraordinarily large because of the presence of villi and microvilli

Answer 35

SMALL INTESTINE

Question 36

Transport process where drugs are moved from the mucosa to the serosa

Answer 36

CARRIER-MEDIATED

Question 37

This is the ability of a drug to exist as optically active stereoisomers or enantiomers

Answer 37

CHIRALITY

Question 38

The rate-limiting step in the bioavailability of a drug is the _________ step

Answer 38

SLOWEST

Question 39

Transport process described by Fick’s Law

Answer 39

PASSIVE DIFFUSION

Question 40

Usually, the amorphous form has a faster dissolution rate than the ______ form

Answer 40

CRYSTALLINE

Question 41

Transport process where drugs are moved uphill against a concentration gradient

Answer 41

ACTIVE

Question 42

Fatty food ________ rate of gastric emptying

Answer 42

DECREASES

Question 43

This is a species formed by the reversible or irreversible association of two or more interacting molecules or ions

Answer 43

COMPLEX FORMATION

Question 44

Which of the following gives the correct order of decreasing rate of absorption?

Answer 44

SOLUTION, EMULSION, SUSPENSION, PELLET

Question 45

Anticholinergic __________ rate of gastric emptying

Answer 45

DECREASE

Question 46

Transport process where drugs or dissolved materials are engulfed by a cell

Answer 46

VESICULAR

Question 47

Modified release tablets are suited for short _________ drugs

Answer 47

HALF-LIFE

Question 48

Tablet coating should break down quickly so as not to hinder the drug’s ____________

Answer 48

BIOAVAILABILITY

Question 49

Transport process where drugs are moved through tight or narrow junctions between cells or transendothelial channels of cells

Answer 49

CONVECTIVE

Question 50

A _________ suspension prolongs gastric emptying, slows down drug dissolution, and decreases absorption rate

Answer 50

HIGHLY VISCOUS

Question 51

This kind of drug can easily cross the membrane of the gastrointestinal tract – NONPOLAR  Most chiral drugs are used as __________ mixtures

Answer 51

RACEMIC

Question 52

Bulky materials in the gastric area tend to empty ______ than liquids

Answer 52

MORE SLOWLY

Question 53

Enteric coating minimizes contact between the drug and the __________ region

Answer 53

GASTRIC

Question 54

This excipient may reduce the wetting of the drug particle

Answer 54

LUBRICANT

Question 55

The contents of a hard capsule should not be subjected to high _______ that reduced the effective surface area

Answer 55

COMPRESSION PRESSURE

Question 56

The most important site for drug absorption in the GI tract

Answer 56

SMALL INTESTINE