Toxic Tablets

Question 1

When should warfarin be taken? [1]

Answer 1

Question 2

When do you need loading regimens of warfarin? [1]

Answer 2

Question 3

Answer 3

Question 4

Wafarin is monitored using …

Answer 4

INR

Question 5

Answer 5

Question 6

St John’s Wort interacts with warfarin to cause an:

Increase in INR
Decrease in INR

Answer 6

St John’s Wort reduces the anticoagulant effect of warfarin.

Question 7

Which ONE of the following electrolyte disturbances is MOST likely to exacerbate lithium toxicity?

Hypocalcaemia
Hyponatraemia
Hypophosphataemia
Hyperkalaemia
Hypomagnesaemia

Answer 7

Drugs which affect renal elimination, or electrolyte balance are likely to affect serum-lithium concentrations.
Serum-lithium concentration may rise due to sodium depletion and may therefore exacerbate lithium toxicity.

Question 8

Which ONE of the following should always be prescribed by brand name?

Digoxin
Lithium
Methotrexate
Warfarin

Answer 8

Lithium

Question 9

Which ONE of the following statements regarding digoxin treatment is CORRECT?

After initiating digoxin, or following a dose change, the full therapeutic effect will not be seen for 8 to 10 days.
A patient on concomitant digoxin and amiloride is at greater risk of toxicity than a patient taking digoxin and furosemide.
Intravenous loading of digoxin is preferred to oral loading as the onset of action is faster.
Thyroid function tests should be routinely monitored.

Answer 9

After initiating digoxin, or following a dose change, the full therapeutic effect will not be seen for 8 to 10 days.

Question 10

How often should the plasma-digoxin concentration be monitored during chronic therapy to reduce the risk of toxicity?

Monthly
Every 3 months
Every 6 months
Annually
Only measure if toxicity is suspected

Answer 10

Only measure if toxicity is suspected