Toxicity Side effects Flashcards
(32 cards)
When to monitor for Lithium
weekly until stable
—> every 3 months (year 1)
——-> every 6 months
When do you record Lithium serum concentration
12 hours after dose
Signs of Lithium Toxicity
SICK and TREMOR
- nausea
- tremor
- increased weeing/thirst
- headache
What organ is not affected by lithium
Liver
What is the therapeutic range for Digoxin
0.7 to 2
When should Digoxin samples be taken
6 hours after dose
What are the signs of Digoxin toxicity apart from Yellow vision
- sick
- confused
- palpitations
What is a rare syndrome you should not give digoxin with
Wolff-Parkinson-White Syndrome
What can be a sign of bone marrow toxicity when taking methotrexate
Mucositis (inflammation of mouth of gut)
What requires discontinuation of methotrexate
- pulmonary toxicity
- bone marrow supression/neutropenia
- Diarrhoea
- Oral mucositis
What should be monitored in methotrexate
- blood
- renal
- liver
When should Methotrexate monitoring take place
- every 1 to 2 weeks until stable
—-> every 2 to 3 months
What should the monitoring frequency be for Methotrexate when taking Leflunomide
monthly for 12 months
What should be monitored with Warfarin
- FBC
- LFT
- renal
- BP
- thyroid
What are signs of toxicity for Theophylline
SICK and FAST
- Nausea
- tremor
- palpitations
- hyperglycaemia
What to not have with Phenytoin
- Enteral feeding (stop it 2 hours before and after dose)
What supplements might be needed for when taking Phenytoin
Vitamin D
When to stop Phenytoin
if rash appears
When to discontinue ciclosporin
- uncontrolled hypertension
- peripheral neuropathy
- hair loss
- rash
What is the interaction of statins and cyclosporin
myopathy
When to measure serum concentration of gentamycin
after 3rd or 4th dose
What are the serum ranges for Vancomycin
10 to 20
What are the signs of toxicity of vancomycin
- sore throat
- brusing
- mouth ulcers
How long after treatment does amiodarone still incur side effects
several weeks to months
