Toxicology Flashcards

(27 cards)

1
Q

How does black widow cause paralysis?

A

Acetylcholine binds Ca channels

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2
Q

How does warfarin tox work?

A

Anticoagulant (2,7,9,10)
Prolongs PT

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3
Q

What is brodifacoum?

A

Vitamin K antagonist

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4
Q

Cholecalciferol toxicity

A

Fatal hypercalcemia
Increased phosphorus

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5
Q

Bromethalin toxicity

A

CNS

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6
Q

Treatment for ethylene glycol

A

4-MP or ethanol

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7
Q

Organophosphate toxicity

A

Inhibits acetylcholinesterase
Hypersalivate, bloat

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8
Q

Treatment for organophosphate tox

A

Atropine or 2-PAM

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9
Q

Strychnine MA

A

Glycine antagonist
Get tremors

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10
Q

Strychnine treatment

A

Methocarbomol

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11
Q

Lillies that accumulate calcium oxalate

A

Peace and cala

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12
Q

What does red maple leaf tox in horses cause

A

Heinz body anemia

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13
Q

Slaframine (moldy red clover)

A

Slobbers

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14
Q

Cantharadin in horses

A

Colic
Cardio shock
Hematuria

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15
Q

Ergot tox in horses

A

Alkaloids
Thrombosis
Colic

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16
Q

Yellow star thistle toxicity

A

Nigropalladial myelomalacia
Loss of prehension
Grave prognosis

17
Q

Locoweed (swainsonine) toxicity

A

Behavior change
Abortion

18
Q

Fescue tox in horses

A

Ergopeptine alkaloids—dopamine agonist
Repro failure in nares
Prolactin suppression
Hoof sloughing

19
Q

Bracken fern toxicity

A

Marrow suppression
Enzootic hematuria
Polioencephalomalacia in horses

20
Q

Milkweed, gossypol, oleander, etc toxicity

A

Acute death
Arrhythmias

21
Q

Ionophore tox in horses

A

Myocardial necrosis
DCM
Hemoglobinuria

22
Q

Perilla mint toxicity

A

Dyspnea
Frothing at mouth

23
Q

Causative agents of fog fever

A

Brassica plants
Tryptophan to 3-MI
Lush forage

24
Q

Moldy sweet potatoes (fusarium)

A

4-IP
Grunt, cough, distress

25
Examples of pyrrolizidine alkaloids
Fiddleneck Groundsel Ragwort Senecio Larkspur
26
Pyrrolizidine alkaloid effects (liver)
Inhibit hepatocyte mitosis Megalocytosis, peripheral fibrosis, bile duct hyperplasia
27
Pyrrolizidine alkaloid effects (other)
Secondary photosensitization Primary photosensitization—St Johns Wort, Brassica, Hypericum