ToxPath Flashcards
1
Q
Which transporter is only expressed in the liver
A
Bsep
2
Q
Aromatic armines MOA
A
glucuronidation and sulfonation increase carcinogenic potential (of parent agents and their hydroxylamine metabolites)
3
Q
Bilirubin MOA tox
A
competition by drugs for UGT1A1 yields hyperbilirubinemia
4
Q
NSAID MOA tox
A
reactive acyl-glucuronides damage macromolecules
5
Q
Favored phase II method of detox?
A
Glucuronidation is favored in most species but is low-capacity pathway in cats (use sulfonation instead)
6
Q
Which are the major routes of excretion of toxic. metabolites?
A
Urinary and biliary
7
Q
What plays a critical role in biliary excretion
A
Xenobiotic transporters in the liver
