Trace Minerals Flashcards

1
Q

Identify the trace minerals

A
iron
zinc
selenium
copper
manganese
fluoride
chromium
molybdenum
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2
Q

_________ requires iron for activation

A

Hydroxylase

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3
Q

________ ______ requires selenium for activation

A

Glutathione peroxidase

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4
Q

_____ is a nutrient of great concern in terms of global and national health.

A

iron

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5
Q

In poor or developing countries of the world, as many as __% to __% of young children and pregnant women have compromised health due to iron deficiency or iron-deficiency anemia.

A

30%-50%

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6
Q

Even in the United States where food is plentiful, ___ deficiency is a health concern for toddlers, adolescent girls, and women in their childbearing years, especially those of low socioeconomic status.

A

iron

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7
Q

Iron has two common ionic states, ________ and ________.

A
  1. Fe++ (ferrous iron, reduced)

2. Fe+++ (ferric iron, oxidized)

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8
Q

Iron is involved in many _________ _______ _______, including the electron transport chain in the final production of ATP in the mitochondria.

A

oxidation- reduction reactions

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9
Q

Since iron has an affinity for oxygen (O2), iron-rich __________ picks up O2 in the lungs and transports it via red blood cells to all parts of the body.

A

hemoglobin

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10
Q

________ in muscle is another Fe-containing protein that binds O2

A

myoglobin

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11
Q

iron is important in brain and nervous tissue function since it is a _______ necessary for the catalytic activity of enzymes responsible for the synthesis of several neurotransmitters.

A

cofactor

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12
Q

Iron embedded in a _____ structure (from hemoglobin and myoglobin) is found only in foods of animal origin and has _____ bioavailability.

A
  1. heme

2. high

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13
Q

________ iron (as Fe++ or Fe+++) is found both in foods of animal origin and in foods of plant origin and has a lower bioavailability.

A

nonheme

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14
Q

Heme iron has higher bioavailability with ___% being absorbed. However, for a vegetarian who eats no animal foods, only about __% of iron is absorbed. Overall in the mixed American diet, about ___% of iron is absorbed.

A
  1. 25%
  2. 10%
  3. 18%
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15
Q

The iron recommendation for vegetarians is ___ times the RDA to compensate for the significantly lower bioavailability of nonheme iron as the only source of dietary iron.

A

1.8

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16
Q

___% of iron is absorbed during the high growth years of childhood.

A

35%

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17
Q

An ____ peptide factor found in meat, fish, and poultry enhances nonheme iron absorption.

A

MFP

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18
Q

_________ in a meal enhances nonheme iron absorption by keeping the form of iron in the reduced state.

A

vitamin C

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19
Q

Plant foods high in _______ and ______ such as in legumes, whole grains, and rice can reduce nonheme iron absorption in a meal by ________ it causing increased excretion in the stool rather than absorption into the body

A
  1. phytates and fibers

2. binding

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20
Q

Iron is always bound to specific proteins in tissues and fluids of the body. ____ _______ proteins play critical roles in iron homeostasis.

A

iron binding

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21
Q

Inside the lumen of the small intestine, iron from food is found in the forms of _____ or _____ iron.

A

heme or nonheme

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22
Q

After iron is transported into the small intestinal cell, either as heme or nonheme iron, it is sequestered by a protein call ______.

A

ferritin

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23
Q

_______ has the capacity to temporarily store thousands of iron atoms. It is also the storage protein for iron in the liver.

A

ferritin

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24
Q

If the body is in need of iron, then _____ in intestinal cells releases iron, which then attaches to _______.

A
  1. ferritin

2. ferroportin

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25
________ is a transport protein and it is associated with the membrane on the blood side of the intestinal cell (also called a mucosal cell).
ferroportin
26
Iron does not travel free in the blood. It is attached to the protein called blood _______, which delivers iron to the body tissues.
transferrin
27
When the body has gotten enough iron, the liver secretes the hormone, ______. It blocks _______ from transferring iron into the blood.
1. Hepcidin | 2. ferroportin
28
IRON EXCRETION _______ cells die at a high rate and are then shed into the intestinal lumen resulting in iron from ferritin being excreted in feces.
Mucosal
29
TRUE OR FALSE Extremely little iron can be excreted in urine since it is protein bound and proteins are not filtered out by the kidney.
TRUE
30
TRUE OR FALSE Women lose iron monthly via menstruation; thus, men and postmenopausal women are at higher risk for toxicity compared to premenopausal women.
TRUE
31
Iron deficiency anemia is a ______ ______ anemia (small cell, low color) that results from not only depleted iron stores, but also depleted ____ transport and reduced production of________.
1. microcytic hypochromic 2. iron 3. hemoglobin
32
Iron deficiency refers to depleted iron stores in the ______, but not severe enough to cause anemia.
liver
33
Iron deficiency may cause _______ and _______ changes often mistaken for laziness; symptoms may include fatigue, decreased ability to concentration, and sluggish reactivity.
behavioral and motivational
34
In the U.S., some behavior and cognitive problems in children have been attributed to lower iron status. Researchers hypothesize that iron's role in the synthesis of _________ is the cause of these symptoms.
neurotransmitters
35
Hereditary iron overload or _________ is the most common genetic disorder in the United States, affecting some 1.5 million people.
hemochromatosis
36
Hemochromatosis can cause _____ ____, ____, ____, and ______.
liver damage apathy lethargy fatigue
37
Adult men require __ mg/day of iron, whereas premenopausal women require more than twice that amount, __ mg/day,
8 mg/day | 18 mg/day
38
The UL for iron is set at __ mg/day in a supplement.
45mg/day
39
More enzymes require ____ compared to any other class of metalloenzymes.
zinc
40
Zinc regulates
1. immune function 2. thyroid function 3. motor and cognitive development in children 4. vitamin A metabolism 5. taste 6. wound healing
41
Severe zinc deficiency is characterized by _______ ______ and _______ sexual maturity in children and adolescents.
1. growth retardation | 2. delayed
42
Plant-based diets high in fiber and phytates can cause the ______. of zinc in the intestine.
binding
43
TRUE OR FALSE | In the US diet, red meat, whole grains, some fortified cereals, and milk are the richest sources of zinc.
TRUE
44
Less than __% of dietary zinc is absorbed into blood.
40%
45
This intestinal storage protein for zinc is called __________.
metallothionein
46
Only when the body needs zinc will ________ release zinc for transport into blood. Zinc is transported in blood attached to a blood protein called ________, however, blood _______ can also transport zinc.
1. metallothionein 2. albumin 3. transferrin
47
Unabsorbed zinc from either diet or pancreatic secretions is excreted in ____.
feces
48
Zinc, iron, and copper have similar chemical characteristics, thus they can interact and _______ in the body.
compete
49
The UL for Zinc is ___mg/day
40 mg/day
50
High iron absorption either from overload disorder or iron supplements can over saturate blood ________, leaving little room for the transport of _____ and resulting in reduced absorption of _____.
1. transferrin 2. zinc 3. zinc
51
Chronic use of zinc supplements can cause decreased absorption of _____ or _____, due to competition with transport.
iron and copper
52
Iodide is part of the structure of the thyroid hormone, _______, which controls basal metabolic rate, body temperature, growth, reproduction, muscle function, and energy metabolism.
thyroxine
53
An iodine deficiency leads to a decreased production of active _____. In an effort to make more, the body increases ______ stimulating hormone, causing cells of the thyroid gland to enlarge in an attempt to trap more iodide.
1. thyroxine | 2. thyroid
54
Thyroid gland enlargement results in a very visible growth on the neck known as a ______ ______.
simple goiter
55
During pregnancy, a thyroid deficiency will cause severe mental and physical retardation of the developing fetus, a condition known as ______.
cretinism
56
TRUE OR FALSE Inadequate dietary iodine is still a major public health issue in developing nations where fortification programs are absent.
TRUE
57
Iodine is abundant in ______ and is present in the soil near the _____.
1. seafood | 2. ocean
58
Iodized _____, introduced in the 1930’s, eliminated iodine deficiency.
salt
59
Fluoride has an important role in the strengthening of ______ and _____.
bones and teeth
60
Fluoride replaces the hydroxyl group in hydroxyapatite (the crystalline structure in bones and teeth) and forms an even stronger compound.
fluorapatite
61
Fluoride naturally occurs in many soils and water supplies, but in areas with low fluoride, __________ of the public water supply (at 1 ppm) has dramatically lowered the incidence of decayed and missing teeth.
flouridation
62
0.1 ppm level of fluoride in drinking water can lead to...
increased incidence of dental caries and missing teeth
63
1 ppm level of fluoride in drinking water can lead to...
optimal dental health
64
8 ppm level of fluoride in drinking water can lead to...
increased incidence of fluorosis
65
Selenium is present in the enzyme, glutathione peroxidase, where, along with vitamin E and other antioxidants, it blocks the formation of _____ ______.
free radicals
66
TRUE OR FALSE | Seafood, meat, whole grains, fruits, and vegetables are all good sources of selenium in the U.S. diet.
TRUE
67
Copper is found in enzymes that affect ________ formation, act as an ______, and are involved in _______ ________.
1. hemoglobin 2. antioxidant 3. energy metabolism
68
______ is part of the enzyme, superoxide dismutase.
Copper
69
superoxide dismutase, like glutathione peroxidase, is very important in reducing ______ _______ formation.
free radical
70
Chromium is notable for its role in ______ and _____ metabolism.
carbohydrate and lipid
71
________ helps maintain glucose levels by enhancing insulin activity.
Chromium
72
Chromium deficiency is characterized by ______-like symptoms.
diabetes
73
TRUE OR FALSE | Chromium is abundant in unrefined foods, meats, cheese, and grains
TRUE