Transcription and disease Flashcards
1
Q
What factors are required for transcription to be able to occur?
A
- Promotors
- Enhancers/ silencers
- Transcription factors
- RNA polymerase
2
Q
What are the steps involved in the processing of mRNA transcripts?
A
5’ capping
Intron removal
Addition of a poly A tail
3
Q
What diseases can be caused by defective transcription factors or promoters?
A
Pituitary dwarfism
Haemophilia B
T-cell Leukemia
Androgen insensitivity syndrome
4
Q
What causes pituitary dwarfism?
A
Mutations in Pit 1 disrupts ability to bind to the promoter
5
Q
What causes haemophilia B?
A
Mutations that affect the IX promoter sequence
6
Q
What causes T-cell leukemia?
A
MAD transcription factor that leads to continued cell growth
7
Q
What causes androgen insensitivity hormone?
A
XY foetuses are not responsive to androgens (testosterone)
