transcription factors

Question 1

oestrogen

Answer 1

• steroid hormone found in animals
  -these are small, hydrophobic lipid based hormones that can diffuse through cell membranes and can pass into nucleus through pores
  -oestrogen diffuses into cytoplasm through CSM
• oestrogen diffuses through a nuclear pore into the nucleus
  -oestrogen attaches to an oestrogen receptor to undergo a conformational change
• the new shape of the receptor allows it to detach from the protein complex and be expressed
  -oestrogen receptor binds to a cofactor which enables it to bind to the promoter region of the gene stimulating RNA polymerase binding and stimulating gene transcription