Transfusion Flashcards Preview

General Haem > Transfusion > Flashcards

Flashcards in Transfusion Deck (10):
1

Partial d

RBCs type as RhD+, but patients can make anti-D

2

Sources of danger error in transfusion

he blood sample
for cross matching is taken from the wrong patient; the wrong name
is written on the blood sample tube; the patient did not need the
transfusion; and bedside verification is not done correctly to ensure
that the right blood product is being given to the right patient at the
right time and in the correct manner.

3

Canadian consensus criteria for trali

Acute lung injuryAcute onsetHypoxemiaResearch setting: PaO2/FlO2 < 300 and/or SpO2 < 90% on room airNon-research setting: PaO2/FlO2 < 300 and/or SpO2 < 90% on room air and/or other clinical symptoms of hypoxiaBilateral infiltrates on frontal chest x-rayNo evidence of left atrial hypertension (i.e., no circulatory overload)No pre-existing acute lung injury before transfusionDuring or within 6 hours of transfusionNo temporal relationship to an alternative risk factor for acute lung injuryPossible TRALI:Acute lung injuryNo pre-existing acute lung injury prior to transfusionDuring or within 6 hours of transfusionA clear temporal relationship to an alternative risk factor for acute lung injury

4

Second hit in trali

 “hit” results from passive infusion of donor antibodies in the blood product that recognize either human leukocyte antigens (HLA) on recipient endothelial cells or human neutrophil antigens (HNA) on recipient neutrophils. 

4

Second hit in trali

 “hit” results from passive infusion of donor antibodies in the blood product that recognize either human leukocyte antigens (HLA) on recipient endothelial cells or human neutrophil antigens (HNA) on recipient neutrophils. 

5

Strategies to reduce the risk of trali

avoiding the use of plasma from female donors, using plasma derived only from males or from never-pregnant females, and testing female donors for anti-HLA antibodies.1,2 Although these measures reduce the incidence, they do not completely eliminate risk because TRALI can be induced by other blood products (e.g., red blood cells, platelet concentrates, cryoprecipitat

6

Ab decreased by enzyme

Mns Duffy

7

Antibodies enhanced bynenxyme

Abo, Rh, kidd, kewis, p

8

IAT phase = AHG

Most clinically significant ab will react here
Usually igG

9

G antibody

Present when D or C or both
RHD, RHCe, or RHCE. are assoc phenotypes