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IMMUNOHEMATOLOGY AND BLOOD BANKING > TRANSFUSION-TRANSMITTED DISEASE > Flashcards

TRANSFUSION-TRANSMITTED DISEASE Flashcards

1
Q

HAV and HEV are transmitted through what MOT

A

fecal/oral route

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2
Q

HBV, HCV, HDV and HGV are primary transmitted via what MOT

A

parenterally

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3
Q

-belongs to the picornaviridae family
-also known a DANE PARTICLE

A

Hep B

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4
Q

it is the first marker to appear and can be detected by polymerase chain reaction

A

HBV DNA

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5
Q

-member of Flaviviridae virus
-accounted for the HIGHEST RATE OF DEATH DUE TO HEPATITIS

A

Hep C

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6
Q

-cannot exist without HBV
-it was previously called the delta antigen

A

Hep D

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7
Q

-major cause of hepatitis globally
-member of caliciviridae family
-leading cause of hepatitis in UK

A

Hep E

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8
Q

-etiologic agents of AIDS
-a retrovirus
-cd4 count less than 200/ul

A

HIV type 1 and 2

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9
Q

is that time after infection but before antibody or antigen is detected by currently available testing procedures

A

window period

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10
Q

the risk of HIV 1 infection through transfusion is

A

1:1,000,000 per unit transfused

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11
Q

-was the first retrovirus to be associated with a human disease
-causes T-cell proliferation with persisiten infection

A

Human T-cell Lymphotropic Virus type I/II

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12
Q

The risk of HTLV-I/II transmission through transfusion is

A

1:2,000,000 per unit transfused

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13
Q

the primary amplifying host in a mosquito-bird-mosquito cycle

A

Bird

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14
Q

an arbovirus
-transmitted by the aedes aegypti and aedes albopictus
-associate with severe neurological complication

A

Zika virus

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15
Q

the most frequent transmitted virus from mother to fetus

A

CMV

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16
Q

-a ubiquitous member of the herpes family
-infection in B lymphocyte
-causes IM “ kissing disease”

A

Epstein-Barr Virus

17
Q

it causes a common childhood illness called “ fifth disease” and usually transmitted through respiratory secretions
-present with a mild rash described as “slapped cheek”

A

parvovirus B-19

18
Q

-a very common virus that causes a lifelong infection
-causes roseola infantum, also known as “exanthem subitum” or “sixth disease”

A

Human herpesvirus 6 and human herpesvirus 8

19
Q

-can cause severe hemorrhagic fever
-8 week deferral

A

Ebola virus

20
Q

most frequent source of septic transfusion reaction because of room temeprsture storage

A

platelets

21
Q

the most common bacterial contaminants of blood

A

staphylococcus epidermidis or staphylococcus aureus

22
Q

most common isolate found in the RBC unit

A

Yersinia enterocolitica , followed by pseudomonas

23
Q

parasites associated with transfusion-associated infection

A

Babesia microti
trypanosoma cruzi
malaria (plasmodium spp)
leishmania soo
trypanosoma spp
toxoplasma gondii

24
Q

usually transmitted by the bite of an infected deer tick
-infects the RBC
-

A

Babesia microti

25
Q

-etiologic agent of chagas disease
-acquired by the bite of a reduviid bug

A

Trypanosoma cruzi

26
Q

in chagas disease, blood smears stained w/ giemsa or wright stain may be examined for the what characteristic

A

C or U shaped trypomastigote

27
Q

persons who traveled to an endemic are are deferred for

A

1 year

28
Q

person who have had malaria or who have immigrated from or lived in an endemic area are deferred for

A

3 years

29
Q

causative agent of CJD

A

prion

30
Q

one of the transmissible spongiform encephalopathies

A

Creutzfeldt-jakob disease

31
Q

rare disease characterized by fatal neurodegeneration that results in sponge-like lesions in the brain

A

(TSEs) transmissible spongiform encephalopathies

32
Q

in human, what is the most common form of CJD v

A

sporadic CJD

33
Q

infectious diseases that req NAT (nucleic acid testing)

A

-hbv
-hiv 1
-hcv
-west nile virus
-zika virus
-babesia microti

IMMUNOHEMATOLOGY AND BLOOD BANKING (3 decks)

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