Transplant Flashcards
What is the MoA of tacrolimus? What are the side effects?
Binds to FKBP, resulting in inhibition of calcineurin and IL-2 synthesis
- Side effects: nephrotoxicity, neurotoxicity, GI toxicity, and HTN
- 100x more potent than cyclosporine
- metabolized by cytochrome P 450 system
What is the MoA of mycophenolate mofetil? What are the side effects?
It is an antimetabolite that inhibits inosine mono phosphate dehydrogenase, an enzyme necessary for de novo purine synthesis. Leads to antiproliferative effect on T and B lymphocytes
- side effects: leukopenia, GI toxicity
What is the MoA of sirolimus? What are the side effects?
It binds FKBP, but does not affect calcineurin. It binds target of rapamycin proteins, leading to halting cell division by preventing progression from G1 to S phase of cell cycle
- side effects: thrombocytopenia, increased serum cholesterol and LDL
What is the MoA of corticosteroids? What are side effects?
Multiple antiinflammatory actions (impairs T cell lymphokine production, causes leukopenia by redistributing lymphocytes)
- side effects: cushingoid state, glucose intolerance, osteoporosis, impaired wound healing
What is the MoA of azathioprine? What are side effects?
It is an antimetabolite and derivative of 6-mercaptopurine that interferes with DNA and RNA synthesis, resulting in suppression of B and T cells
- side effects: bone marrow suppression (thrombocytopenia, anemia, neutropenia), hepatotoxicity
MoA of cyclosporine is?
What are the side effects?
Binds to cyclophilin, leading to inhibition of calcineurin and IL-2 synthesis.
- adverse effects: nephrotoxicity, tremor, HTN, hirsutism, gingival hyperplasia
- is metabolized by cytochrome P 450 system
