Treatment

Question 1

Treatment goals

Answer 1

1. prevent mortality + morbidity by qSOFA + intervention
2. early implementation therapies - fluid resuscitation + antimicobials
3. reduce/ eliminate organ dysfunction
4. elminiate source of infection
5. avoid adverse reactions to treatment
6. provide cost-effective therapy

Question 2

General approach to treatment

Answer 2

1. recognition sepsis + early implementation therapy
2. fluid therapy = restore intravascular volume depletion
3. early adm broad spec antimicrobial
4. inotropic therapy = maintain haemodynamic stability - not improved with fluid
5. IV hydrocortisone - haemodynamically unstable - despite fluid + inotropic
6. glucose control via infucsion regular insulin
7. adjunctive therapy
   - blood products
   - sedation
   - analgesia
   - NMB
   - RRT
   - DVT prophylaxis
   - stress ulcer prohylaxis
   - nutrition

Question 3

Focus of treatment

Answer 3

• infection
• inflammation
• hypoperfusion
• wide spread tissue injury