Treatment of CNS and Respiratory Infections Flashcards Preview

Immunology / Micro > Treatment of CNS and Respiratory Infections > Flashcards

Flashcards in Treatment of CNS and Respiratory Infections Deck (32):

What antibiotics typically don't reach sufficient levels in the CSF?

the 30S inhibitors -> tetracyclines / aminoglycosides, + polymyxins


What is the empiric coverage we use for meningitis in patients <1 month?

Ampicillin + gentamicin or cefotaxime (3rd generation not ceftriaxone)

Gentamicin is okay because patient has no BBB


What is the empiric coverage for meningitis in patients 1-23 months of age and why?

Vancomycin + 3rd generation cephalosporin

Use vancomycin for possibility of mildly elevated MICs of Streptococcus pneumoniae which would not allow killing by cephalosporin in CSF


What is the only difference between treating adults under 50 and children for CNS infection?

Adults get Dexamethasone prior to first antibiotic dose


What is the purpose of giving dexamethasone?

It is a steroid to decrease inflammation in subarachnoid space and thus decrease neurological sequelae


What must be added onto the antibiotic regimen for adults >50 and why?

ampicillin, for listeria coverage

So regimen is:
ampicillin + vancomycin + ceftriaxone


What can be used against Listeria if patient is allergic to ampicillin?



Who gets prophylaxis for meningitis caused by N. meningitis and H. influenzae and what is it?

N. meningitis - anyone exposed to oral secretions and household contacts - Ciprofloxacin 500 mg or rifampin

H. influenzae - everyone in a household with unvaccinated children (might spread to them) - Rifampin


What is the most common causative pathogen in CSF shunt infections, and what is the recommended empiric treatment?

Usually coag-negative staph (from skin)

Recommended broad therapy: Vancomycin + cefepime or ceftazidime


What is the basic treatment for all fungal CNS infections minus Coccidio?

Lipid Amphotericin B + flucytosine for all
Blasto and Histo longer therapy, and longer oral therapy

Recommend switching to oral azole therapy after a few weeks


What is the recommended therapy for only Coccidio CNS infection?

High dose fluconazole


Typically acute bronchitis is not treated. What are the exceptions? What is used to treat?

Mycoplasmal, chlamydial, or B. pertussis

All use Macrolides with second line doxycycline


During a COPD exacerbation, who gets antibiotics?

Only those with increased sputum purulence


What are the most common bugs for COPD exacerbation?

S. pneumoniae, H. influenzae, M. catarrhalis (typical pathogens)

With some Chlamydia or mycoplasma


What is the first-line treatment for COPD exacerbation?

Doxycycline, with second-line amoxicillin/clavulanic acid


Who gets IV therapy for COPD exacerbations and what is it?

Those at high risk for poor outcome -> frequent exacerbations, comorbidities, and Abx use

It is ampicillin/sulbactum (basically IV augmentin)


How long are COPD exacerbations treated?

3-7 days


What are the only times you treat for sinusitis, since it is usually viral?

When signs / symptoms are persistent >10 days, with no improvement, or the symptoms are severe with purulent discharge / facial pain at least 3-4 days


What is the therapy for sinusitis?

Same as outpatient COPD: amox/clav or Doxycycline


What are "the big 6" of Community-Acquired pneumonia?

1. Streptococcus pneumoniae
2. Hemophilus influenzae
3. Moraxella cattarhalis
4. Mycoplasma pneumoniae
5. Chlamydia pneumoniae
6. Legionella pneumophilia


What is given to healthy CA-pneumonia and high risk CA-pneumonia in outpatient therapy?

Previously healthy: azithromycin or doxycycline

High risk: beta-lactam + azithromycin or doxycycline


For inpatient non-ICU CAP, what is the treatment?

Azithromycin or doxy + 3rd generation ceph, or respiratory fluoroquinolone


For inpatient ICU CAP, what is the treatment?

Same drugs, but IV is necessary. Can add Vancomycin if concern for MRSA


What is the treatment of choice for outpatient aspiration pneumonia?

Amoxicillin/clavulanic acid (good gram negative / anaerobe coverage)


What is the treatment of choice for inpatient aspiration pneumonia?

Ampicillin / sulbactam (IV version of augmentin)


What dictates the duration of therapy for community-acquired pneumonia?

Minimum of 5 days, must be afebrile for 48-72 hours, and no more than one "sign of instability"

1. Fever, leukocytosis, tachycardia, tachypnea


What is the empiric therapy for HAP/HCAP/VAP?

1. Antipseudomonal beta-lactam
2. Antipseudomonal FQ or aminoglycoside
3. MRSA coverage: Vancomycin or linezolid


What organism throws a wrench in your HAP/HCAP/VAP plans?

Acinetobacter baumanii -> resistant to many drugs

Typically you need tigecycline or polymyxins since it is gram negative


What is the duration of therapy recommended for HAP bugs?

7 days, assuming initial response to drugs and no pseudomonas


What should be done if the HAP is not MRSA? What should be done with pseudomonas?

Immediately discontinue vancomycin

Also de-escalate the anti-pseudomonal drugs to narrowest one possible


How should you treat Stenotrophomonas maltophilia pneumonia?

TMP/SMX is the drug of choice


Why do we give CF patients high dose antibiotics and often aerosolized antibiotics?

High dose - they metabolize the drugs super fast

Aerosolized - just want to suppress the infection, we aren't gonna stop it entirely

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