Trials

Question 1

Which trial evaluated the use of corticosteroids in ARDS patients?

Answer 1

The RECOVERY trial

Question 2

Fill in the blank: The _____ trial assessed the efficacy of early goal-directed therapy in sepsis.

Answer 2

ProCESS

Question 3

Which medication was primarily evaluated in the SOAP II trial?

Answer 3

Dopamine

Question 4

True or False: The SOAP II trial found that dopamine improved outcomes in critically ill patients.

Answer 4

False

Question 5

What was the main finding of the PROWESS trial regarding drotrecogin alfa (activated)?

Answer 5

It showed a reduction in mortality in severe sepsis patients.

Question 6

What is the significance of the CRASH-2 trial?

Answer 6

It demonstrated the effectiveness of tranexamic acid in trauma patients.

Question 7

Which trial studied the impact of intensive glucose control in critically ill patients?

Answer 7

The NICE-SUGAR trial

Question 8

What was the outcome of the NICE-SUGAR trial?

Answer 8

It found that intensive glucose control increased mortality.

Question 9

Which trial focused on fluid resuscitation strategies in sepsis?

Answer 9

The ARISE trial

Question 10

Fill in the blank: The _____ trial investigated the use of high-flow nasal cannula in acute respiratory failure.

Answer 10

FLORALI

Question 11

What was a key finding of the FLORALI trial?

Answer 11

High-flow nasal cannula improved outcomes compared to standard oxygen therapy.

Question 12

What is the purpose of the SPRINT trial?

Answer 12

To assess the effects of intensive blood pressure control in patients.

Question 13

True or False: The SPRINT trial recommended a target systolic blood pressure of less than 120 mmHg.

Answer 13

True

Question 14

What intervention was evaluated in the VASST trial?

Answer 14

Vasopressin versus norepinephrine in septic shock.

Question 15

What did the VASST trial conclude about vasopressin?

Answer 15

It is comparable to norepinephrine for treating septic shock.

Question 16

Which trial investigated the use of low tidal volume ventilation in ARDS?

Answer 16

The ARDSnet trial

Question 17

What was the conclusion of the ARDSnet trial?

Answer 17

Low tidal volume ventilation reduced mortality in ARDS patients.

Question 18

What is the main focus of the ICU-ROX trial?

Answer 18

To assess the effects of early mobilization in critically ill patients.

Question 19

True or False: The ICU-ROX trial found that early mobilization improved physical function.

Answer 19

True

Question 20

Which trial addressed the use of antibiotics in HAP?

Answer 20

The ATLANtic trial

Question 21

What was a key finding of the ATLANtic trial?

Answer 21

Early appropriate antibiotics improved outcomes in HAP.

Question 22

Fill in the blank: The _____ trial evaluated the effect of sedation strategies in mechanically ventilated patients.

Answer 22

SLEAP

Question 23

What conclusion did the SLEAP trial reach regarding sedation?

Answer 23

Light sedation strategies are beneficial for mechanically ventilated patients.

Question 24

What is the significance of the TTM trial?

Answer 24

It studied targeted temperature management after cardiac arrest.

Question 25

What was the main finding of the TTM trial?

Answer 25

Targeted temperature management improved neurological outcomes.

Question 26

Which trial assessed the use of dexmedetomidine in critically ill patients?

Answer 26

The SEDCOM trial

Question 27

What was a key conclusion of the SEDCOM trial?

Answer 27

Dexmedetomidine was associated with reduced delirium in ICU patients.

Question 28

What does the acronym ECMO stand for?

Answer 28

Extracorporeal Membrane Oxygenation

Question 29

Which trial evaluated the use of ECMO in severe respiratory failure?

Answer 29

The EOLIA trial

Question 30

What was the conclusion of the EOLIA trial?

Answer 30

ECMO did not improve survival compared to conventional treatment.

Question 31

What is the primary goal of the FROG-ICU trial?

Answer 31

To assess the effects of early fluid resuscitation in ICU patients.

Question 32

True or False: The FROG-ICU trial found that early fluid resuscitation improved survival rates.

Answer 32

True

Question 33

What intervention was studied in the CORTICUS trial?

Answer 33

Corticosteroids in severe sepsis.

Question 34

What was a significant finding of the CORTICUS trial?

Answer 34

Corticosteroids did not significantly reduce mortality in severe sepsis.

Question 35

Fill in the blank: The _____ trial focused on the effects of blood product transfusion in critically ill patients.

Answer 35

TRICC

Question 36

What conclusion did the TRICC trial reach?

Answer 36

Restrictive transfusion strategies are safe and may be preferable.

Question 37

Which trial was pivotal in establishing the use of low-dose aspirin in critically ill patients?

Answer 37

The ADAPT trial

Question 38

What was the conclusion of the ADAPT trial?

Answer 38

Low-dose aspirin did not improve outcomes in critically ill patients.

Question 39

What is the focus of the VAP trial?

Answer 39

Ventilator-Associated Pneumonia prevention strategies.

Question 40

True or False: The VAP trial concluded that oral care reduces the incidence of VAP.

Answer 40

True

Question 41

What does the acronym RCT stand for?

Answer 41

Randomized Controlled Trial