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MRCP Psychiatry > Tricyclic Antidepressant > Flashcards

Tricyclic Antidepressant Flashcards

1
Q

How do tricyclics exert an antidepressant effect?

A

inhibition of the reuptake of neurotransmitters 5HT and noradrenaline

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2
Q

What other receptors are acted on by tricyclics which contribute to their side effect profile?

A

antagonism of:
- histamine receptors
- muscarinic receptors
- adrenergic receptors

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3
Q

Side effects caused by antagonism of histamine receptors

A

drowsiness

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4
Q

Side effects caused by antagonism of muscarinic receptors

A

blurred vision
dry mouth
constipation
urinary retention

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5
Q

Side effects caused by antagonism of adrenergic receptors

A

postural hypotension

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6
Q

Tricyclics lengthen the QT interval. TRUE/FALSE?

A

TRUE

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7
Q

Give examples of more sedative tricyclic antidepressants

A

Amitriptyline
Clomipramine
Dosulepin
Trazodone

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8
Q

Give examples of less sedative tricyclic antidepressants

A

Lofepramine
Nortriptyline

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9
Q
A
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MRCP Psychiatry (27 decks)

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