TSE 2 Flashcards
(25 cards)
FSE (feline)
-UK 1990
-present in domestic cats and big game cats
-not zoonotic
-
FSE transmission
-eating contaminated meat
1. horizontal transmission: cat eating cat or prion shredding in urine
2. vertical transmissioni: cheetah mother disease to offspring thru nursing
FSE incubation
- 4.5-8yrs
FSE clinical signs
- aggression, timd
-ataxia beginning hind legs
-circling and head tilt: vacant stare
-polydipsia/ polyphagia
Camel prion disease (CPD)
-algeria
-dromedary camels
CPD clinical signs
-ataxia, tremors, bruxism
-loss of appetite
-hyperesthesia (hyper reactivity)
-aggression
-retrospective study: 3.1% of all camels w neurological disease = CPD positive
CPD cause
-unknown
-diff prion than crapie or bse
-infectious form of prion
CWD clinical signs
-profound weight loss and deterioration
-behaviour changes: unafraid of ppl- can be docile or aggressive
-excessive salivation, urination/drinking
-play legs
-head tremors
-avg incubation period: 18-24 months
-plaques
CWD species affected
-NA: white tial deer and mule deer and rock mt deer and moose
-scandinavia: eurasian tundra reindeer, moose
-north AB caribou at risk
-contries w cwd: usa, canada, south korea, sweden, norway, finland
indirect routes of transmission
1.infected enviro: ingestion of contaminated soil and forage and enviro persistence
2. infected amterials
3. indirect contact w infected animals
infected enviro CWD
-cohabitation of naive deer w infected deer
-naive deer lived in paddic that hosueed infected deer
-naive deer housed in paddock that had decomposed infected corpse
cwd effectivity in enviro
-bind to common soil minerals ex montmorillonite = increase infectivity by 650x
-grazing animals consume >100g of dirt per day
infected materials CWD
-fomites and cervid materials
-equipment
-animal products
-improper disposal of carcasses
infected animals indirect cwd
-contact prion infected material
-ex. domestic cat shaving access to food enclsoures
Direct contact transmission cwd
-infected captive cervid: unexpected intro of infected cwd cervi dinto naive herd
-80% newly infected herds imported cervids from other farms
farm contact risk
-high risk: 50m radius
-possible risk: up to 300mile radius
cwd control strats
- fencing
- genetics
- diagnostic testing
- vaccine
- otjher
fencing
-good repair no holes
-secondary fence line ex. electrified
genetics control
-breeding genetically resistant CWD cervids
-polymorphism of CWD prion resistance- potential for breeeding CWD resistance
diagnostic testing
-gold standard: IHC of lymphoin and neurological tissue- ELISA
-RAMALT: recto-anal mucosa assoc lymphoid tissue
=good screen tool for herd
-new: RTQULC potential to detect cwd prion in feces, saliva, urine
canada cwd
-only confirmed diagnosis is dead cervids
-madatory reporting to cfia all suspect animals
-mandaotry testing all farmed cervids over 12months of age
-no cwd positive animal can enter commercial food chain
vaccination
ineffective and not approved in canada
-slowed disease onset but still got infected
-salmonella vector vaccine: prolonged incubation to 300d
-vaccine w modifed prion: elk developed faster onset compared to unvacc elk
other preventative treatment
-treatment: cervids provided tannic acids, tetracycline pentose polysulphide - still developed cwd
-copper: did not improve survivability or susceptibility
cwd species barrier
-conformation of prion is more important than species affected _ some prions strains more infective than others
