TSGs and oncogenes quick Flashcards
1
Q
Templeton 2014
A
RTK = worse OS
2
Q
Konduri 2016
A
EGDR-RAD51
3
Q
Bang 2017
A
margetuximab better than trastuzumab
4
Q
Harvey 1964
A
ras sarcoma rats
5
Q
Mulcahy 85
A
Ras + serum, anti ras abs
6
Q
Filmus 94
A
Ras + anti cyclin D = decrease prolif
7
Q
mituhashi 1995
A
Ras and VEGF
8
Q
AMG510
A
KRAS NSCLC 2019 50% response rates phase 1
9
Q
Davies 2002
A
dna seq 66% mal mel
10
Q
Chapman 11
A
84 64 74
11
Q
Bar-Peled 2013
A
Gator
12
Q
Yao 2011
A
everolimus for neuroendocrine PFS
13
Q
Colman 2009
A
rhesus fasting
14
Q
Decamps 2005
A
mice fasting
15
Q
Kerr Wylie and Currie 1972
A
n con cell frag phago
16
Q
Sulston 76
A
1090 c el
17
Q
Horvitz 83
A
ced 3 and ced 4
18
Q
Evan 1992
A
apoptosis rat 1 myc
19
Q
serrano 97
A
sensence fibro G12V HRAS
20
Q
Patton 05
A
zebrafish braf
21
Q
Montes de oca luna 95
A
double mdm2 and p53 ko
22
Q
Bond 2004
A
seq mdm2 sp1
23
Q
Dannenburg 2000
A
TKO S phase
24
Q
Foijer 2005
A
TKO apoptosis bcl2 rni p53
25
Hockenbury 90
bcl2 lymph lifespan
26
Strasser 90
bcl2 + Mac = faster tumours
27
Beroukhim 2010
increase bcl2 in solid
28
Blombery 2019
pre/post venetoclax mutation for res
29
He 2007
mir37 p53 chip
30
daige2014
1/3 mice reg mir34
31
APR246
MDS pIII 44 CR
32
Lu ox 2001
ASPP and apoptosis
33
Nunney 18
height and cancer
34
Xentuzumab
ifn1/2 non visceral
35
martincorema 2015
skin drivers
36
martincorema 2018
oesophageal drivers
37
Nicolas 2003
notch1 as tsg
38
wodarz 2007
computation model - dont stop apoptosis
39
RTK = worse OS
Templeton 2014
40
EGDR-RAD51
Konduri 2016
41
margetuximab better than trastuzumab
Bang 2017
42
ras sarcoma rats
Harvey 1964
43
Ras + serum, anti ras abs
Mulcahy 85
44
Ras + anti cyclin D = decrease prolif
Filmus 94
45
Ras and VEGF
mituhashi 1995
46
KRAS NSCLC 2019 50% response rates phase 1
AMG510
47
dna seq 66% mal mel
Davies 2002
48
84 64 74
Chapman 11
49
Gator
Bar-Peled 2013
50
everolimus for neuroendocrine PFS
Yao 2011
51
rhesus fasting
Colman 2009
52
mice fasting
Decamps 2005
53
n con cell frag phago
Kerr Wylie and Currie 1972
54
1090 c el
Sulston 76
55
ced 3 and ced 4
Horvitz 83
56
apoptosis rat 1 myc
Evan 1992
57
sensence fibro G12V HRAS
serrano 97
58
zebrafish braf
Patton 05
59
double mdm2 and p53 ko
Montes de oca luna 95
60
seq mdm2 sp1
Bond 2004
61
TKO S phase
Dannenburg 2000
62
TKO apoptosis bcl2 rni p53
Foijer 2005
63
bcl2 lymph lifespan
Hockenbury 90
64
bcl2 + Mac = faster tumours
Strasser 90
65
increase bcl2 in solid
Beroukhim 2010
66
pre/post venetoclax mutation for res
Blombery 2019
67
mir37 p53 chip
He 2007
68
1/3 mice reg mir34
daige2014
69
MDS pIII 44 CR
APR246
70
ASPP and apoptosis
Lu ox 2001
71
height and cancer
Nunney 18
72
ifn1/2 non visceral
Xentuzumab
73
skin drivers
martincorema 2015
74
oesophageal drivers
martincorema 2018
75
notch1 as tsg
Nicolas 2003
76
computation model - dont stop apoptosis
wodarz 2007
