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Flashcards in Tuberculosis Deck (14):
1

Tuberculosis caused by what bacterium?

Mycobacterium

2

What is the character of Tuberculosis infection?

slow growing chronic disease relatively resistant to antibiotics or develops resistance quickly

3

Why is mycobacterium of tuberculosis hard to treat?

Slow growing makes it harder to target (antibiotics work well against fast growing cells)

4

What four major agents are used for treatment of active tuberculosis infections?

1. Isoniazid
2. Ethambutol
3. Rifampin
4. Streptomycin

5

Is isoniazid bacteriostatic or bacteriocidal?

–static on slowgrowers
-cidal on fast growers

6

What is the method of action of Isoniazid?

Inhibits synthesis of mycolic acid, required for mycobacterium cell wall

7

What drug combined with Isoniazid results in hepatotoxicity?

Rifampin

8

Is ethambutol bacteriostatic or bacteriocidal?

–static

9

What is the ethambutol method of action?

Inhibits incorporation of mycolic acid in to cell wall

10

What is the character of mycobacterium resistant to ethambutol?

Quick resistance when given alone

11

What is rifampin's target?

DNA dependent RNA polymerase to inhibit initiation of chain formation

12

Is rifampin bacteriostatic or bacteriocidal?

Bacteriocidal

13

Drug resistant mycobacterium tuberculosum dictates what type of therapy?

Multidrug therapy

14

Why does multidrug therapy help treat tuberculosis?

It decreases the likelihood of mycobacterium developing resistance to all three drugs as they have different targets.