Flashcards in Tuberculosis Deck (14):
Tuberculosis caused by what bacterium?
What is the character of Tuberculosis infection?
slow growing chronic disease relatively resistant to antibiotics or develops resistance quickly
Why is mycobacterium of tuberculosis hard to treat?
Slow growing makes it harder to target (antibiotics work well against fast growing cells)
What four major agents are used for treatment of active tuberculosis infections?
Is isoniazid bacteriostatic or bacteriocidal?
–static on slowgrowers
-cidal on fast growers
What is the method of action of Isoniazid?
Inhibits synthesis of mycolic acid, required for mycobacterium cell wall
What drug combined with Isoniazid results in hepatotoxicity?
Is ethambutol bacteriostatic or bacteriocidal?
What is the ethambutol method of action?
Inhibits incorporation of mycolic acid in to cell wall
What is the character of mycobacterium resistant to ethambutol?
Quick resistance when given alone
What is rifampin's target?
DNA dependent RNA polymerase to inhibit initiation of chain formation
Is rifampin bacteriostatic or bacteriocidal?
Drug resistant mycobacterium tuberculosum dictates what type of therapy?