Tubular Reabsorotion And Secretion Flashcards

1
Q

Makes largest contribution for Reabsorption

A

PCT

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2
Q

The transfer of material from blood and tubule cells into filtrate

A

Secretion

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3
Q

Two important out comes from secretion

A

Secretion of H ions help control blood pH

Secretion of other items help eliminate them from the body

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4
Q

The top of soda cans

A

Apical

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5
Q

Bottom and sides of soda cans

A

Basolateral

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6
Q

Apical membrane contacts what type of fluid

A

Tubular fluid

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7
Q

Basolateral membrane contacts what type of fluid

A

Interstitial

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8
Q

Two types of Reabsorption routes

A

Paracellular

Transcellular

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9
Q

Water and solutes return to blood stream by moving between tubule cells

A

Paracellular

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10
Q

Water and solutes in tubular fluid pass through a tubule cell to return to blood stream

A

Transcellular

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11
Q

Function of tight junctions in tubule cells

A

Allows solutes to diffuse across them to return to peri tubular capillary

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12
Q

Why does renal tubules have a low concentration of Sodium ions in their cytosol

A

Na/K pump

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13
Q

Where are Na-K pumps located in the renal tubule cells?

A

The Basolateral portion

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14
Q

Lack of Na/K pump in the apical surface ensures what

A

Reabsorption of Na is one way process

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15
Q

Primary active transport

A

ATP is used to pump a substance across a membrane

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16
Q

Secondary active transport

A

Energy stored in an ions electrochemical gradient drives substance across a membrane

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17
Q

Membrane proteins that move two or more substances in the same direction across a membrane

A

Symporters

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18
Q

Move two or more substances in opposite direction across a membrane

A

Anti porters

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19
Q

The upper limit on how fast a transporter can work

A

Transport maximum

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20
Q

Obligatory water Reabsorption

A

Water is obliged to follow the solutes that are absorbed

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21
Q

Facultative water Reabsorption

A

The last 10 percent of water Reabsorption that may be needed

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22
Q

Regulates facultative water Reabsorption

A

ADH

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23
Q

Most solute Reabsorption in the PCT involves this ion

A

Na

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24
Q

How does sodium transport occur in the PCT

A

Symport

Antiport mechanisms

25
Na glucose Symporters
Two Na ions One glucose Bind to the protein
26
How does glucose molecules leave tubular cell
Diffusion
27
When the glucose diffuses it heads to what in the interstitial fluid
Peri tubular capillaries.
28
Na/H antiporters
H ions are secreted into lumen Na ions are Reabsorbed to bloodstream
29
Role of carbonic anhydrase
Catalyze carbon dioxide and water to make carbonic acid
30
What happens when a secreted H is secreted into tubule
It reacts with HCO3 to form carbonic acid
31
Carbonic acid dissociates to form
Hydrogen and HCO3
32
What Happens when HCO3 levels rise in cytosol
It is diffused back into the blood stream
33
For every H ion secreted into tubular fluid
One HCO3 and one Na ion is Reabsorbed
34
Solute Reabsorption of PCT promotes
Osmosis
35
Aquaporin
Protein in plasma | Membrane that increase rate of water movement across the apical and Basolateral membrane
36
Symporters of thick ascending limb of loop of henle
Na , K and two Cl
37
Cells in thick ascending limb of the loop of henle allow for the simultaneous Reabsorption of
One K One Na Two Cl
38
The distal convuluted tube allows for Reabsorption of
Na
39
The DCT allows for secretion of
K
40
How is Na Reabsorbed back to the blood stream of DCT
Na K pump
41
The return of filtered water and solutes to the blood
Reabsorption
42
what is secreted when blood volume and pressure drop
Renin
43
what happens to the arterioles when blood volume and pressure drop
they are stretched less
44
Renin clips off what from angiotensin
angiotensin I
45
Converts angiotensin I to angiotensin II
ACE
46
How does Angiotensin II affect renal physiology
decreases filtration enhances reabsorption of Na and Cl stimulates the release of aldosterone
47
what is aldosterone
hormone released by adrenal cortex
48
what is the purpose of aldesterone
Causes more reabsorption of Na and CL
49
What is the purpose of more reabsorption of Na and Cl
more water is reabsorbed, allowing blood volume and pressure to increase.
50
Releases ADH
Pituitary gland
51
Purpose of ADH
Increases facultative reabsorption of water decreases osmolarity of bodily fluids
52
What triggers ADH
High blood osmolarity decreased blood volume
53
Promotes ANP
High blood volume
54
Produces ANP
Stretching of atrium
55
Purpose of ANP
Suppresses​ reabsorption of Na and water in PCT, decrease blood volume and pressure
56
ANP inhibits
Aldosterone and ADH
57
Promotes release of PTH
Decreased level of Calcium
58
Releases PTH
Posterior Pituitary
59
What does PTH do?
Causes reabsorption of Calcium