Tumor dedifferentiation/differentiation or redifferentiation Flashcards
(4 cards)
1
Q
What is cellular plasticity?
A
dramatic shift in cellular phenotype
2
Q
Why is cellular plasticity important in cancer biology?
A
Because it contributes to the progression of the tumor, to metastatic potential and to resistance to therapeutic interventions
3
Q
What is tumor cell dedifferentiation?
A
When a tumor cell loses it’s specialized properties and takes on a less differentiated phenotype
4
Q
How does dedifferentiation lead to escape of immune surveillance?
A
- loss of differentiation associated antigens
2. transcriptional changes that result in the recruitment of immunosuppressive myeloid cells
