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Clinical Chemistry 2 > Tumor Markers > Flashcards

Tumor Markers Flashcards

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1
Q

1846- H. Bence-Jones

A

Bence-Jones protein

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2
Q

1928- W.H. Brown

A

Ectopic hormone syndrome

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3
Q

1930- B. Zondek

A

hCG

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4
Q

1932- H. Cushing

A

ACTH

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5
Q

1949- K. Oh-Uti

A

Deletions of blood group antigens

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6
Q

1959- C. Market

A

Isoenzyme

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7
Q

1963- G.I. Abelev

A

AFP

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8
Q

1965- P. Gold and S. Freeman

A

CEA

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9
Q

1969- R. Heubner and G. Todaro

A

Oncogenes

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10
Q

1975- H. Kohler and G. Milstein

A

Monoclonal antibodies

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11
Q

1980- G. Cooper, R. Weinberg, and M. Bishop

A

Oncogenes probe and transfection

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12
Q

1985- H. Harris, R. Sager, and A. Knudson

A

Supressor gene

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13
Q

Alcohol dehydrogenase

A

ASSAY: ACT
CANCER TYPE: Liver

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14
Q

ALS

A

ASSAYY: ACT
CT: Liver

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15
Q

ALP

A

ASSAY: ACT
CT: Bone, liver, leukemia, sarcoma

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16
Q

ALP-placenta

A

ASSAY: ACT
CT: Ovarian, lung, trophoblastic, GIT, seminoma, Hodgkin’s

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17
Q

AMS

A

ASSAY: ACT
CT: Pancreatic, various

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18
Q

Aryl sulfatase B

A

ASSAY: ACT
CT: Colon, breast

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19
Q

CK-BB

A

ASSAY: ACT
CT: Prostate, lung (small-cell), breast, ovarian

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20
Q

Esterase

A

ASSAY: ACT
CT: Breast

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21
Q

Galactosyltransferase

A

ASSAY: ACT
CT: Colon, bladder, GIT, various

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22
Q

GGT

A

ASSAY: Liver

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23
Q

Hexokinase

A

ASSAY: ACT
CT: Liver

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24
Q

LAP

A

ASSAY: ACT
CT: Pancreatic, liver

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25
LDH
ASSAY: ACT CT: Liver, lymphomas, leukemia, various
26
Neuro-specific enolase
ASSAY: RIA CT: Lunng (small cell), neuroblastoma, carcinoid, melanoma, pheochromocytoma, pancreatic
27
5’-NT
ASSAY: ACT CT: Liver
28
ACP- Prostatic
ASSAY: ACT/MIA CT: Prostate
29
PSA
ASSAY: IMA CT: Protate
30
PK
ASSAY: ACT CT: Liver, various
31
Ribonucleases
ASSAY: ACT CT: Various (ovarian, lung, large bowel)
32
Sialytransferase
ASSAY: ACT CT: Breast, colon, lung
33
tdt
ASSAY: ACT CT: Leukemia
34
Thymidine kinase
ASSAY: RIA/ACT CT: Various, leukemia, lymphomas, lung (small cell)
35
ACTH
CANCER TYPE: Cushing’s syndrome, lung (small cell)
36
ADH
CANCER TYPE: Lung (small cell), adrenal cortex, pancreatic, duodenal
37
Bombesin
CANCER TYPE: Lung (small cell)
38
Calcitonin
CANCER TYPE: Medullary thyroid
39
Gastrin
CANCER TYPE: Glucagon
40
GH
CANCER TYPE: Pituitary adenoma, renal, lung
41
hCG
CANCER TYPE: Embryonal, choriocarcinoma, testicular (nonseminomas)
42
Human placental lactogen
CANCER TYPE: Trophoblastic, gonads, lung, breast
43
Neurophysin
CANCER TYPE: Lung (samll-cell)
44
PTH
CANCER TYPE: Liver, renal, breast, lung, various
45
PRL
CANCER TYPE: Pituitary adenoma, renal, lung
46
Vasoactive intestinal peptide
CANCER TYPE: Pancrease, bronchogenic, pheochromocytoma, neuroblastoma
47
AFP
NATURE: Glycoprotein, 70 kd, 4% CHO CANCER TYPE: Hepatocellular, germ cell (nonseminoma)
48
b- Oncofetal antigen
NATURE: Glycoprotein, 80 kd CANCER TYPE: Colon
49
Carcinofetal ferritin
NATURE: Glycoprotein, 600 kd CANCER TYPE: Liver
50
CEA
NATURE: Glycoprotein, 22 kd, 50% CHO CANCER TYPE: Colorectal, GIT, pancreatic, lung, breast
51
Pancreatic oncofetal
NATURE: Glycoprotin, 40 kd CANCER TYPE: Pancreatic
52
Squamous cel antigen
NATURE: Glycoprotein, 44-48 kd CANCER TYPE: Cervical, lung, skin, head & neck (squamous)
53
Tennesse antigen
NATURE: Glycoprotein, 100 kd CANCER TYPE: Colon, GIT, bladder
54
Tissue polypeptide antigen
NATURE: Cytokeratins 8, 18, 19 CANCER TYPE: Various (breast, colorectal, ovarian, bladder)
55
CA 125
Ag & SOURCE: GP, >200kd, OVCA 433 Ab: OC 125 CANCER TYPE: Ovarian endometrial
56
CA 15-3
Ag & Source: GP, 400kd, membrane-enriched BrCa Ab: DF3 & 115D8 CANCER TYPE: Breast, ovarian
57
CA 549
Ag & Source: HMW GP Ab: BC4E549, BC4N154 CANCER TYPE: Breast, ovarian
58
CA 27, 29
Ag & Source: HMW GP Ab: B27.29 CANCER TYPE: Breast
59
MCA
Ag & Source: 350-kd GP Ab: b-12 CANCER TYPE: Breast, ovarian
60
DU-PAN-2
Ag & Source: Mucin, 1000-kd peptide epitope Ab: DU-PAN-2 CANCER TYPE: Pancreatic, ovarian, GIT, lung
61
CA A9-9
Ab & Source: Sialylated Le^xa, SW-1116 colon CA Ab: 19-9 CANCER TYPE: Pancreatic, GIT, hepatic
62
CA 19-5
Ab & Source: Le^a & Sialylated Le^ag Ab: 19-5 CANCER TYPE: Pancreatic, GIT, ovarian
63
CA 50
Ab & Source: Sialylated Le^a and afucosyl Ab: C50 CANCER TYPE: Pancreatic, GIT, colon
64
CA 72-4
Ab & Source: Sialylated Tn Ab: B27.3, CC49 CANCER TYPE: Ovarian, breast, GIT, colon
65
CA 242
Ab & Source: Sialylated CHO Ab: C242 CANCER TYPE: GIT, pancreatic
66
b2- Microglobulin
NATURE: 11 kd CANCER TYPE: Multiple myeloma, B-cell lymphoma, CLL, Waldenstron’s macroglobulinemia
67
C-peptide
NATURE: 3.6 kd CANCER TYPE: Insulinoma
68
Ferritin
NATURE: 450 kd Fe-binding protein CANCER TYPE: Liver, lung, breast, leukemia
69
Immunoglobulin
NATURE: 160-900 kd, 3-12% CHO CANCER TYPE: Multiple myeloma, lymphomas
70
Melanoma-associated antigen
NATURE: 90-240 kd CANCER TYPE: Melanoma
71
Pancreas-associated antigen
NATURE: 100 kd, 20% CHO CANCER TYPE: Pancreatic, stomach
72
Pregnancy-specific protein 1
NATURE: 10 kd, 30% CHO CANCER TYPE: Trophoblastic, germ cell
73
Prothrombin presursor
NATURE: Des-r-carboxy prothrombin CANCER TYPE: Hepatocellular
74
Tumor-associated trypsin-inhibitor
NATURE: 6 kd-polypeptide CANCER TYPE: Lung, GIT, ovarian
75
Estrogen & progesterone receptors
NATURE: (Tissue) CANCER TYPE: Breast
76
Cathecholamine metabolites
NATURE: (Urine) VMA, HVA, metanephrines CANCER TYPE: Neuroblastma, pheochromocytoma
77
Hydroxyproline
NATURE: (Urine) CANCER TYPE: Bone metastasis (breast), multiple myeloma
78
Lipid-associated sialic acid
NATURE: Sialic acid CANCER TYPE: GIT, lung, rheumatoid
79
Polyamine
NATURE: (CSF), (URINE) CANCER TYPE: Brain, Various
80
N-ras mutation
FUNCTION: Signal transduction PRODUCT: GDP/GTP binding protein TYPE OF CANCER: Acute myeloid leukemia neuroblastoma
81
K-ras mutation
FUNCTION: Signal transduction PRODUCT: GDP/GTP binding protein TYPE OF CANCER: Leukemia, lyphoma
82
c-myc translocation
FUNCTION: Transcription regulation PRODUCT: Binds to DNA TYPE OF CANCER: B and T lymphoma, small cell lung carcinoma
83
c-erb B-2 amplification
FUNCTION: Growth receptor PRODUCT: Tyrosine kinase TYPE OF CANCER: Breast, ovarian, gastrointestinal
84
c-ab/bcr translocation
FUNCTION: Signal transduction PRODUCT: Tyrosine kinase TYPE OF CANCER: Chronic myelocytic leukemia
85
N-myc amplification
FUNCTION: Transcription regulation PRODUCT: Binds to DNA TYPE OF CANCER: Neuroendocrine
86
bcl-2
FUNCTION: Blocks apoptosis PRODUCT: Mitchondrial membrane protein TYPE OF CANCER: Leukemia, lymphoma
87
3p
TUMOR TYPE: Kidney GENE: VHL mutation
88
5q21
TUMOR TYPE: Colorectal GENE: APC mutation
89
9p21
TUMOR TYPE: Bladder, glioblastoma, melanoma GENE: p16 (cdka2) mutation
90
11p13
TUMOR TYPE: Wilms’ tumor GENE: WT1 mutation
91
11p15
TUMOR TYPE: Wilms’, breast, hepatoblastoma, rhabdomayosarcoma, bladder GENE: Loss of heteroxygosity
92
13q
TUMOR TYPE: Breast GENE: BRCA2, RB1
93
13q14
TUMOR TYPE: Retinoblastoma, osteosarcoma, small-cell lung GENE: RB1 mutation
94
16q
TUMOR TYPE: Breast GENE: P16 E-cadherin mutation
95
17q
TUMOR TYPE: Neurofibrosis 1, melanoma, breast GENE: BRCA 1 MUTATION
96
17P13
TUMOR TYPE: Breast, colorectal, lung, liver, renal cell, bladder, sarcomas GENE: p53 mutation
97
18q21
TUMOR TYPE: Colorectal GENE: DCC mutation
98
22q
TUMOR TYPE: Neurofibromatosis 2, meningioma GENE: NF2 MUTATION

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