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Tumor Markers Flashcards

(80 cards)

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1
Q

SIS B Chain PDGF

A

Astrocytoma , osteosarcoma

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2
Q

EGF-TGF a

A

Astrocytoma , hepatocellular carcinoma

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3
Q

HST1

A

Stomach cancer

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4
Q

INT2 (official name FGF3)

A

Bladder cancer, Breast cancer, Melanoma

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5
Q

HGF

A

Thyroid cancer

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6
Q

ERB-B1

A

Squamous CC of lung , gliomas

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7
Q

ERB-B2/ HER2 /neu

A

Breast and ovarian

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8
Q

FMS

A

Leukemia

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9
Q

RET

A

MEN 2A and 2B , Familial medullary Thyroid carcinoma

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10
Q

KIT

A

GI stromal tumours, soft tissue tumors (Seminoma)

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11
Q

PDGF-R

A

Gliomas, leukemias

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12
Q

H-RAS

A

kidney, bladder

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13
Q

K-RAS

A

Colon, pancreas. Lung

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14
Q

N-RAS

A

Haematological malignancies, melanoma

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15
Q

ABL: BCR

A

CML (95%) , ALL (5%)

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16
Q

BRAF

A

Melanoma

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17
Q

Beta CATENIN

A

Hepatoblastoma, hepatocellular carcinoma

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18
Q

C-MYC

A

Burkitts lymphoma t(8:14)

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19
Q

N-MYC

A

Neuroblastoma, Small CC of lung

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20
Q

L-MYC

A

Small CC of lung

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21
Q

CYCLIN D Translocation

A

Mantle cell Lymphoma t(11:14)

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22
Q

CYCLIN D Amplification

A

Breast / esophagus

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23
Q

CYCLIN E

A

Breast

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24
Q

CDK4

A

Glioblastomas, melanomas, sarcoma

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25
P16
Melanomas
26
P53
Li- Fraumeni Syndrome
27
RB
Retinoblastoma, osteocarcoma, breast
28
NF1
Neurofibroma, Fibrosarcoma
29
APC
Colorectal, lung, esophagus, stomach, pancreas
30
NF2
Bilateral schwannoma
31
TGF-BETA
Pancreas, colon
32
VHL
Renal cysts, Renal CC, pheochromocytoma, hemangiomas of CNS, retinal angioblastoma
33
PTEN
Cowden syndrome- breast, thyroid, endometrial
34
TSC1
Tuberous sclerosis
35
TSC2
Tuberous sclerosis
36
WT1
Wilms tumor (nephroblastoma)
37
WT2
Wilms tumor (nephroblastoma)
38
DPC4/SMAD4
Pancreatic adenocarcinoma
39
DCC
Colorectal cancer
40
INK4A/ARF
familial melanoma, sq CC of esophagus, sporadic pancreatic adenocarcinoma
41
E-cadherin
Familial gastric cancer
42
TGF-β receptor
Carcinomas of colon
43
BCL2
Follicular Bcell lymphoma t(14:18)
44
ATM
Malignant lymphoma
45
BRCA1
Breast , ovary, prostate, colon
46
BRCA2
Breast
47
CD45
Common leukocytic antigen, leukocytic malignancies
48
S100
Neuroendocrine tumors
49
NSE
Neuroendocrine tumors
50
Cytokeratin
Adenocarcinomas
51
EMA
Epithelial: carcinoma
52
CEA
Colorectal and pancreatic adenocarcinomas
53
Vimentin
Sarcoma
54
Desmin
Muscle derived sarcoma
55
Factor VIII
Tumors of epithelium
56
AFP
HCC, yolk sac tumor or ovary or testis
57
BENCE JONES PROTEIN
Multiple myeloma, waldenstroms macroglobinemia
58
CA 15-3
Breast
59
CA 19-9
Pancreas, colon, stomach
60
CA 125
Surface derived ovarian cancer
61
PSA
Prostatic carcinoma
62
CD10
Renal CC , Acute lymphoblastic leukemia, follicular lymphoma, burkitt lymphoma
63
CD15, CD30
Hodgkins disease, popcorn cells/ RS cells/ lacuner cells
64
CD1a
Langerhan’s Histiocytosis
65
CD3
T cell lymphoma
66
CD20
B cell lymphoma
67
CD11c, CD25, CD103
Hairy cell lymphoma
68
Human Chorionic Gonadotropin
Trophoblastic tumors, nonseminomatous testicular tumors
69
Calcitonin
Medullary carcinoma of thyroid
70
Catecholamine
Pheochromocytoma
71
Prostatic acid phosphatase
Prostate cancer
72
Neuron Specific Enolase
Sm CC of lung, neuroblastoma
73
Tonofilaments
Epithelial tumors
74
Weibel Palade Bodies
Angiosarcomas
75
Neurosecretory Granules
APUD tumors
76
Melanosomes
Malignant melanoma
77
Birbeck Granules
Histiocytic tumor
78
Alkaline Phosphatase
Seminoma
79
Bombesin
Neuroblastoma, lung, gastric
80
TRAP
Hairy cell leukemia

Path tumor marker (1 decks)

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