Tumor Surpressor Genes

Question 1

Describe a Tumor Suppressor Gene

Answer 1

Loss of function results in increased risk off cancer.

***Both alleles must be lost for expression of the disease.

Question 2

APC

Answer 2

Associated Tumor: Colorectal Cancer (associated with FAP)

Question 3

BRCA1/ BRCA2

Answer 3

Associated Tumor: Breast and ovarian cancer

Gene Product: DNA Repair Protein

Question 4

CPD4/SMAD4

Answer 4

Associated Tumor: Pancreatic Cancer

Gene Product: DPC (“Deleted in Pancreatic Cancer”)

Question 5

DCC

Answer 5

Associated Tumor: Colon Cancer

Gene Product: DCC (“Deleted in Colon Cancer”)

Question 6

MEN1

Answer 6

Associated Tumor: MEN Type 1

Question 7

NF1

Answer 7

Associated Tumor: Neurofibromatosis Type 1

Gene Product: RAS GTPase activating protein (neurofibromin)

Question 8

NF2

Answer 8

Associated Tumor: Neurofibromatosis Type 2

Gene Product: Merlin Protein

Question 9

p16

Answer 9

Associated Tumor: Melanoma

Gene Product:CDKI2A

Question 10

p53

Answer 10

Associated Tumor: most human cancers and Li-Fraumeni Syndrome
Gene Product: Traanscription factor for p21; blocks progression from G1 to S phase

Question 11

PTEN

Answer 11

Associated Tumor: Breast, endometrial and prostate cancer

Question 12

Rb

Answer 12

Associated Tumor: Retinoblastoma and osteosarcoma

Gene Prodcut: Inhibits E2F; blocks progression from G1 to S phase

Question 13

VHL

Answer 13

Associated Tumor: von Hippel-Lindau disease

Gene Product: inhibits hypoxia inducible factor 1A

Question 14

WT1 and WT2

Answer 14

Associated Tumor: Wilms Tumor (nephroblastoma)