Tumors

Question 1

Tumors:
• Classified according to

Answer 1

cell of origin & degree of differentiation

Question 2

Primary CNS Tumors in children

Answer 2

70% are primary & infratentorial. ‘

Question 3

Primary CNS Tumors in adults

Answer 3

70% are supratentorial & are primary or secondary.

Question 4

Primary CNS Tumors spread through

Answer 4

CSF (CSF seeding)

Question 5

Gold standard of examination is

Answer 5

Biopsy

Question 6

Presentation of Primary CNS Tumors

Answer 6

Localizing signs ± ↑ ICP

Question 7

Gliomas example

Answer 7

I. Astrocytoma & variants
II. Oligodendroglioma
III. Ependymoma

Question 8

Embryonal (Primitive) neoplasm

Answer 8

Medulloblastoma (posterior fossa)

Question 9

Neuronal Tumors examples

Answer 9

I. Central neurocytoma
II. Ganglioglioma
III. Dysembryoplastic neuroepithelial tumor

Question 10

Parenchymal Tumors

Answer 10

I. Primary CNS Lymphoma
II. Germ Cell Tumors ‘

Question 11

Nerve Sheath tumors example

Answer 11

I. Schwannoma
II. Neurofibroma

Question 12

Most common intracranial tumors in adults:

Answer 12

1- Metastatic
2- Glioblastoma multiforme (GBM), grade 4 astrocytoma
3- Anaplastic astrocytoma
4- Meningioma

Question 13

Most common intracranial tumors in children:

Answer 13

1- Astrocytoma
2- Medulloblastoma
3- Ependymoma

Question 14

Most common in adult females

Answer 14

MENINGIOMA

Question 15

Tumor cells contain PROGESTERONE receptors

Answer 15

MENINGIOMA

Question 16

MENINGIOMA sites

Answer 16

Parasagital, Falx, sphenoid

Question 17

METASTATIC TUMORS of CNS

Answer 17

More common than primary

disseminate by blood

Question 18

METASTATIC TUMORS Majority of tumors disseminate by blood & parallels anatomical distribution of regional blood flow

Answer 18

• Grey-white matter junction
• Border zone between MCA and PCA distributions
• Often MULTIPLE
• Marked edema is seen around metastasis

Question 19

METASTATIC TUMORS Origin of solid primary tumors

Answer 19

• Lung (most common)
• Breast
• Gastrointestinal

• Kidney
• Melanoma

Question 20

Less common tumor generally but with special propensity to metastasize to brain

Answer 20

Germ cell tumours , Thyroid ‘

Question 21

Tumors of Peripheral Nervous System

Answer 21

mainly at cerebellopontine
angle

solitary

Usually benign

adults

Example: SCHWANNOMA & neurofibroma

Question 22

more in Neurofibromatosis in adults

Answer 22

SCHWANNOMA & neurofibroma

Question 23

diffuse or nodular lesions in skin or subcutaneous tissue.

This is description of which tumour

Answer 23

Neurofibromas

Question 24

When Schwannomas & neurofibromas be multiple

Answer 24

hereditary / Familial

Question 25

Tumer in Cerebellopontine angle is often شو أسم الورم

Answer 25

Schwannoma ACOUSTIC NEUROMA → Deafness يؤدي إلى فقدان السمع

Question 26

Antoni A

Answer 26

hypercellular, pallisated area

Question 27

Antoni B

Answer 27

hypocellular, non pallisated (more loose)

Question 28

encapsulated in peripheral, spinal, cranial sites This is the typical description of which tumor

Answer 28

Schwannoma