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Flashcards in Tumour Deck (329)
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241

Tumours that mets to bone

breast

lung

thyroid

renal

prostate

*all the paired organs

242

What are the three treatment facets of a MM bone lesion?

 

With a confirmed diagnosis, the treatment of multiple myeloma involves radiotherapy, bisphosphonates +/- surgical stabilization.

 

Surgical stabilization is utilized when there is a complete or impending fracture. 

243

CD31 & polyvinyl chloride exposure is a risk for what?

ANgiosarcoma

rare

244

What is the local recurrence rate with ABC?

Name 1 adjunct that may help decrease local recurrence?

25% local recurrence

High speed burr

Phenol

Less common in older kids

245

Bloodwork for metastasis with unknown origin?

Spep/upep

CBC

Esr

Lytes

Liver enzymes

Psa

Alp

LDH

246

Survival of Chordoma?

60% 5 year survival

25% long term survival

local extension may be fatal

247

What kind of biopsy is contraindicated in chordoma?

transrectal

248

Maffuccis is characterized by:

A) multiple enchondromas, hemangiomas, lymphangiomas

B) multiple enchondromas in a unilateral distribution

C) auto-dominant transmission, multiple enchondromas and osteochondromas

A

249

What does it mean if a Tumor is biphasic?

It contains both epithelial and mesemchymal neoplastic cells

250

For ewings sarcoma, what blood markers should be added to the typical malignant work up and why?

CBC, esr and crp to differentiate it from osteomyelitis

 

In ewings esr will be up (but not crp?)

251

Indications for marginal resection of lipoma (4)

Symptomatic lesions

Rapidly growing mass

Deep to fascia or in retroperitoneum

Spindle cell & pleomorphic variants

252

 

What term is typically used to describe the following genes: p53 and RB-1

 

Tumor suppressor genes.

253

In terms of tumour location, what are apophyses treated like?

Epiphysis

THINK: locations for chondroblastoma (GT apophysis, calcaneal apophysis etc...)

254

3 dDx for anterior tibial liesion

osteofibrous dysplasia

adamantinoma

malignant fibrous histiocytoma

255

 

What tumor am I?

 

Estrogen Beta Positive

Locally invasive but benign

Can treat with Tamoxifen

Associated with FAP and Dupuytrens

 

Extra-Abdominal Desmoid Tumor

256

Lifetime risk of malignant transformation for solitary enchondroma?

 

1%

257

What is special about biphasic sarcomas in terms of metasteses?

They can go to lymph nodes, which is unusual for sarcomas.

 

Also they metastasize to locations other than the lungs.

258

Name 2 types of benign periepheral nerve sheath tumours

What's the difference

Scwannoma: only made up of Schwan cells

Neurofibroma: Arises from Schwann cells but also has other cells (fibroblasts etc)

259

PVNS typically contains which pigment?

Hemosiderin deposits

260

Gene associated with primary ABC?

Tre2

261

3 Predictors of UNSUCCESSFUL treatment of UBC with steroids

active lesion

large size

multiloculated

262

Long standing chronic draining wounds or burn scar are at risk of what?

Transformation into SCC (Marjolin's ulcer)

263

What Tumor is usually epiphyseal in skeletally immature with chicken wire calcifications?

Chondroblastoma

 

Also has mononuclear chondroblasts

264

Name 3 soft tissue tumours that chemo can help with:

Synovial sarcoma

Leiomyosarcoma

Rhabdomyosarcoma (only in paediatric population, not adults)

265

Common presentations in Chordoma?

bladder & bowel changes are common!

palpable on rectal exam

266

What staging investigation must you include in epitheliod sarcoma (and certain other soft tissue sacomas)

Sentinel LN biopsy

267

Li-Fraumeni syndrome:

what germ line mutation & tumour is it associated with

p53

osteosarcoma

also: breast, colon Ca

268

Name 4 vertebral body tumours

hemangioma

GCT

chordoma

multiple myeloma

Lymphoma

269

What is the most common benign radiation induced tumour of bone?

osteochondroma

270

 

Indications for bone marrow biopsy?

(i.e. what tumors necessitate this)

 

  1. Ewings
  2. Multiple Myeloma
  3. Rhabdomyosarcoma