Tumour Suppressor Genes Flashcards
(26 cards)
List seven TSG
APC p53 BRCA1 Rb PTEN MLH1 P16INK4A
What does BRCA1 do?
Cell cycle regulation
Where does the product of BRCA1 act?
Nucleus
Which cancers are BRCA1 implicated in?
Breast, ovarian, prostate
What is the product of PTEN?
Lipid and tyrosine phosphatase
Where does the product of PTEN work?
Cytoplasm
Which cancers are PTEN implicated in?
Prostate
Glioblastoma
Which pathway is APC involved in, and what is its target?
WNT signalling - Beta catenin
What does the product of MLH1 do?
DNA mismatch repair
Which cancers are MLH1 implicated in?
Colon
Gastric
What does the product of p16INK4A do?
Regulates cell cycle
Where does the product of p16INK4A act?
Nucleus
P16INK4A is implicated in which cancers?
Colon
Which TSG are implicated in colon cancer?
APC
MLH1
P16INK4A
Which two TSG are implicated in prostate cancer?
BRCA1
PTEN
Which TSG is implicated in glioblastoma?
PTEN
Name a TSG involved in gastric and colon cancer
MLH1
What is the function of the Rb protein?
Controls transcription and cell cycle proliferation
Where does p53 act?
Nucleus
What inactivates p53?
MDM2 (or HDM2)
What is the function of p53?
Regulates cell cycle
What are TSG?
Genes which regulate cellular proliferation and maintain cell integrity
What are some characteristics of TSG related cancers?
Tumours are often bilateral
Can be inherited
Explain the mutation hypothesis behind:
inherited cancer
sporadic cancer
Inherited - 1 inherited mutation, 1 acquired mutation
Sporadic - 2 acquired mutations
