Type 3 HSR

Question 1

Type 3 HSR is also known as?

Answer 1

Immune complex disease

Question 2

Duration of Phase 1 of Type 3 HSR

Answer 2

5-7 days

Question 3

Important event/result of Phase 1 of HSR3?

Answer 3

Ab-Ag formation

Question 4

Most dangerous Ab-Ag complex formed in HSR3

Answer 4

Medium sized Ab-Ag complex.

Small: Too small to be pathogenic enough (Low
pathogenicity)
Medium: Most dangerous
Large: Easily phagocytosed

Question 5

Complement activation takes place in which phase of HSR3

Answer 5

Phase II

Question 7

Complement activated in HSR3

Answer 7

Complement 5a (C5a)

Question 8

Time taken for clinical manifestations to arise in HSR3

Answer 8

10-14 days

Question 9

Phase in which clinical manifestations arise in HSR 3

Answer 9

Phase III

Question 10

_______ in complement _____ indicates active immune complex disease.

Answer 10

DECREASE in COMPLEMENT 3a indicates active immune complex disease.

Question 11

Examples of Type III HSR

Answer 11

“SHARP”

S: Serum Sickness/SLE/Schick test
H: Henoch-Schonlein Purpura
A: Arthus Reaction (Localized immune complex disease)
R: Rheumatoid arthritis (Yersinia infection)/ Type 2 Lepra reaction/ Raji’s
Assay
P: Post streptococcal Glomerulonephritis/ Polyarteritis nodosa (strep inf.)

Question 12

Classical example of immune complex reacion which is ass/ w/ endogenous antigen

Answer 12

SLE. All other antigens in HRS Type III are exogenous

Question 13

Classical example of localized immune complex reaction in HSR Type III

Answer 13

Arthus reaction: Since it is controlled and experimental, it affects only one organ)

Question 14

Clinical manifestations of HSR3

Answer 14

• Arthralgia,
• Glomerulonephritis,
• Pleuritis/Pericarditis,
• Rash,
• LN Enlargement

Question 15

Example of a disease entity that’s both Type II and Type III HSR

Answer 15

SLE

Question 16

Which renal complication ass/ w/ SLE shows WIRE LOOP LESION?

Answer 16

Lupus nephritis Type 4 GN (a.k.a Diffuse Proliferative GN)

Question 17

Mgmt. for SLE

Answer 17

1) Steroids (DOC)
2) NSAIDS
3) DMARDS (Severe cases)

Question 18

Drugs responsible for Drug-induced Lupus

Answer 18

“SHIP”

S: Sulfonamide (Dapsone)
H: Hydralazine
I: Isoniazid
P: Procainamide

Question 19

Antibody produced in drug-induced lupus

Answer 19

Anti-histone Ab

Question 20

The two organs that are not involved in drug induced lupus but are involved in SLE

Answer 20

Kidney and Brain

Question 21

Mgmt. of drug-induced lupus

Answer 21

Withdrawal of the offending drug

Question 22

Antibodes produced in SLE

Answer 22

• Anti-ANA
• Anti-DsDNA
• Anti-Smith Ab
• Anti-Ro Ab
• Anti-Beta2 Glycoprotein Ab

Question 23

Antibody most sensitive to diagnosis of SLE

Answer 23

Anti-ANA

Question 24

Antibodies most specific for SLE

Answer 24

1) Anti-Ds DNA

2) Anti-Smith Ab

Question 25

Antibody responsible for increasing the risk of congenital heart block in fetus.

Answer 25

Anti-Ro Ab

Question 26

Antibody responsible for increasing the risk of clot formation, particularly in pregnant women, resulting in repeated abortions (Anti-Phospholipid Ab Syndrome)

Answer 26

Anti-Beta2 Glycoprotein Ab