Types Of Fc Receptors Flashcards
(4 cards)
1
Q
FcyRI (CD64)
A
High affinity for IgG, IgG3>IgG1 (Kd=10^-8M)
On Macrophages, neutrophils, eosinophils
Cause phagocytosis and cell activation
2
Q
FcyRII (CD32)
A
Low affinity (Kd = 2x10^-6M)
On macrophages, neutrophils, DCs, B cells, Nk Cells
Cause phagocytosis, cell activation, feedback inhibition
3
Q
FcyRIII (CD16)
A
Low affinity (Kd=10^-6M)
On NK Cells
Cause Ab-dependent cell mediated cytotoxicity
4
Q
FcERI
A
High affinity (Kd=10^-10M) binds monomeric IgE
Mast cells, basophils, eosinophils,
Cell activation, granulation
