U1 - Reversible Binding of Phosphate and the control of conformation Flashcards
What causes a conformational change in proteins?
An addition or removal of phosphate
What is a form of post-translational modification?
An addition or removal of phosphate
What does Kinases do?
It catalyses the transfer of a phosphate group to other proteins
What happens to the terminal phosphate of ATP
ATP > ADP + Pi the leftover phosphate is transferred to specific R groups
What catalyses the reverse reaction of Phosphorylation?
Protein Phosphatases
What happens when a protein is phosphorylated?
It affects the proteins activity as it has changes conformation.
Why is reverse binding of phosphate useful?
It regulates the activity of cellular proteins such as enzymes and receptors.
“some proteins are _______ by phosphorylation while other are ______”
Activated
Inhibited
What can happen when a phosphate is added?
Due to the negative charge. ionic interactions in the unphosphorylated protein can be disrupted and new ones created.
What charge does a phosphate group add?
Negative
