UG III - Tumors

Question 1

RCC whats that

Give 1 Histo feature of 1 type of RCC

Answer 1

From Tubule Epithelium

• adenocarcinoma; AKA renal adenocarcinoma
• most common is Clear Cell type
• Polygonal cells w clear cytoplasm w branching vasculature

Question 2

Urothelial Carcinoma of Kidney whats that

Give 1 Histo feature

Answer 2

From Transitional Epithelium

Mostly Papillary, Often Multifocal

Question 3

Wilms Tumor

Answer 3

Nephroblastoma, kids tumor

Greyish White, Soft
Triphasic w these components:

• Sheets of small blue cells - Blastema component
• Spindle cells - Stromal
• Abortive tubular, glomeruloid - Epithelial

Question 4

Malignant Kidney tumors clinical presentation [3]

Answer 4

Painless Haematuria
Mass in flank
Fever from necrosis

Question 5

Benign Kidney Tumor

Origin +
4 types of cells present

Answer 5

Angiomyolipoma;

Mesenchymal tumor from M Stem Cells;

Blood vessels
Spindle Cells
Adipose Cells - Yellow

Perivascular epithelioid cells

Question 6

Bladder Carcinoma

Answer 6

Urothelial Carcinoma, papillary lol

Low Grade non invasive papillary; papillary can invade tho

High Grade dysplastic

Question 7

Prostate Benign

Pathophysiology
Cx from bladder upwards

Answer 7

BPH

• due to 5ARD converting T to DHT
• DHT stimulates growth
• transitional zone (malignant cancer @ periphery)

Bladder - obstruction, hypertrophy
- distension, diverticulum
- UTI
Calculi formation, Hydronephrosis Hydroureter
CKD from obstruction

Question 8

Prostate Malignant

Answer 8

Prostate Adenocarcinoma

• note theres acinar and ducts in prostate

Question 9

Prostate Tests

Answer 9

Serum Prostate Specific Antigens
- increased w hyperplasia but not specific for cancer

Biopsy

Question 10

Penis Lesion

Cause

Answer 10

Warts

Condyloma Acuminatum
HPV 6, 11

Question 11

Penis Malignant

Answer 11

SCC

HPV 16, 18

Question 12

Testicular tumors Germ Cell Tumors

1 + 4

Answer 12

Seminomas
Origin from Seminiferous tubules germinal epithelium

• Radiosensitive
• No serum markers
• Lymph Node spread

Non-Seminomatous (can mix w seminoma)
Origin from not seminiferous tubules

• Embryonal carcinoma
• Yolk Sac Tumor
• Choriocarcinoma
• Teratoma - males malignant

Note also have stromal tumors involving Sertoli and Leydig cells;

Question 13

Name all cancers of Kidney + Bladder + Prostate [5]

Answer 13

Malignant

• RCC Clear Cell Type - tubule epithelium
• Urothelial Carcinoma - transitional epithelium
• Wilms’s tumor/ Nephroblastoma

Benign
- Angiomyolipoma; have perivascular epithelial cell

Bladder - Urothelial Carcinoma
Prostate - Prostate Adenocarcinoma