UNAPROVED AGENTS- PHENTOLAMINE Flashcards
How does phentolamine contribute to erectile function?
Phentolamine reduces peripheral adrenergic tone and enhances cholinergic tone, resulting in improved cavernosal filling and proerectogenic effects.
Why is monotherapy with phentolamine avoided for erectile dysfunction?
Monotherapy with phentolamine is avoided because large doses are required for an erection, leading to prevalent systemic hypotensive adverse effects.
What is the typical ratio of papaverine to phentolamine in an intracavernosal injection mixture?
A typical ratio is 30 mg papaverine to 0.5 to 1 mg phentolamine.
What is the most common adverse effect of intracavernosal phentolamine?
Hypotension is the most common adverse effect of intracavernosal phentolamine, especially with large doses or improper injection technique.
