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UNCOMMON Flashcards

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1
Q

are missing on PNH III RBCs, which are devoid of all glycophosphoinositol (linked glycoproteins)

A

• Yt antigens are missing on PNH III RBCs, which are devoid of all glycophosphoinositol (linked glycoproteins)

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2
Q

-a high incidence antigen expressed by 99.8% of Caucasian donors

A

Yta

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3
Q

are expressed on RBCs, neural synapses, neuromuscular junctions

A

Cartwright antigens

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4
Q
  • Clinically benign
  • not associated with HDFN
  • arised from immune stimulation
  • shortened cell survival and delayed HTR
    -usually detected in iat
A

Anti-yta and anti-ytb

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5
Q
A
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6
Q
A
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7
Q

More likely to cause a monocytolayer asay with decreased cell survival

A

Anti-yta

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8
Q

Is a critical enzyme required for the rapid degradation of acetylcholine on postsynaptic membrenes of nerves and muscles

A

AChE(acetylcholinestorase)

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9
Q

Specific for RBC and Erythropoietic Tissues

A

Scianna

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10
Q

• the antigens are relatively resistant to enzymes but can be weakened with DTT and AET

A

Scianna blod group system

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11
Q

associated with warm autoimmune hemolytic anemia

A

Autoantibodies against Scl and Sc3 antigens

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12
Q

Is sciana associated with htr and hdfn?

A

No only hdfn

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13
Q

Which antibody of ISBT 013 is associated with HDFN

A

Anti-Sc4 and anti-Sc2
- have been associated with HDFN

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14
Q

• its structure suggests that it may play a role in RBC adhesion and signaling

A

ERMAP

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15
Q

• the Igy domain possesses a Clq recognition sequence that may mediate adhesion between marrow macrophages and erythroblasts in erythroid islands

A

ERMAP

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16
Q

could be involved in immune recognition and autoimmune anemia

A

ERMAP

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17
Q

Which part of ermap mediates adhesion between marrow macrophages and erythroblasts in erythroid islands

A

the Igy domain possesses a Clq recognition sequence

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18
Q
  • poor immunogens
  • mRNA has benn identified In: RBC, fetal liver and spleen
A

Dombrock

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19
Q

• high incidence antigens found on virtually all donors

A

Gya, Hy, Joa,DOYA, and DOMR

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20
Q

commonly found in mixturos of alloantibodies and can be difficult to identily

A

Dombrock

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21
Q

Isbt 014 whose antibody reactivity can be enhanced by the use of papain or ficin treated RBCS

A

Dombrock

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22
Q

antibody reactivity is reduced or abolished by the treatment of red cells with sulthydryl reducing ogents (DTT, AET), trypsin, chymotrypsin, pronase

A

Dombrock

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23
Q

• IgG, Immune Stimulation
• Clinically significant. many are benign
• capable of causing shortened RBC survival and acute and delayed hemolytic transfusion reactions

A

Dombrock

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24
Q

Can isbt 014 cause htr and hdfn

A

• capablo of causing shortened RBC survival and acute and delayed hemolytic transfusion reactions

Anti Dombrock is not associated with HDFN

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25
can be observed in paroxysmal nocturnal hemoglobinuria type III (PNH III)
Acquired Do null phenotype
26
characterized by chronic hemolysis due to an absence of all GPI linked glycoproteins, including Cromer, Dombrock and Cartwright antigens
paroxysmal nocturnal hemoglobinuria type III (PNH III)
27
may play a role in clearing circulating NAD+ and/of posttranslational modification of proteins
Dombrock
28
may also contribute to integrin-mediated cell adhesion
Dombrock
29
What are the antigens of the colton blood group system
4 antigens: Coa, Cob, Co3, COA • Coa high incidence Ag (937% donor) * Cob 11% of donors; only 0.3% are Co (a b+) phenotype * Co (a-b-) nuil Very rare • Antibody against Co a
30
Located in the RBCS, PCT, descending LOH, renal vasa recta, endothellum, choroid plexus, ciliary body, microvessels, gall bladder, placenta & some epithelial calls
Colton blood group system
31
clinically significant antibodies associated with shortened red cell survival, HT& and HDFN
Colton
32
• immune antibodies • can sometimes bind Complement
Colton
33
ISBT 015 is enhanced by
AHG, protease treatment
34
Expression of this antigen is dependent on RhD protein expression Originated from the discovery of the D antigen
LW
35
Plasma origin,absorbed on rbc and is of high incidence
LW blood group
36
Lw
Expression of LW antigen is dependent on RhD protein expression Originated from the discovery of the D antigen
37
Does lw cause htr and hdfn
• clinically benign antibodies, IgG, rarely cause HDFN and HTR
38
• agglutinates all cells except Rh null Cells
anti LW
39
• • a potential counterreceptor for the b2 integrin protein Mac1(CD11b/CD18), LFA 1 (CDIla/CD18), and platelet GPIlb /IIIa
LW glycoprotein
40
may participate in adhesive interactions during early erythroid development may also be involved in red cell senescence by binding to CD11/CD18 integrin on splenic macrophages
LW glycoprotein
41
is elevated in sickle cell patients and may be involved in microvascular occlusion
LW
42
Does gerbich cause htr and hdfn
No
43
• of plasma origin and are passively adsorbed onto RBC membranes • weakly expressed on cord RBCs and some GYPA deficient RBCs
Gerbich
44
Rare reports of anaphylaxis plasma and platelet transfusion
Gerbich
45
antibody reactivity can be enhanced by incubating ABCs in a low lonic sucrose solution
Gerbich
46
antibody reactivity can be inhibited by plasma or by treatment of RBCS with proteases
Gerbich
47
• NEUTRALIZATION: serum (contains complement)
Gerbich
48
49
Its Glycoproteins are on: RBCs, Platelets, Kidneys, fetal Liver
Gerbich
50
017
Gerbich
51
52
• Decrease antigens in patients with horeditary elliptocytosis due to protein 41 deficienty
Gerbich
53
Does gerbich cause htr and hdfn
cause delayed HTR and severe HDN
54
causes low RBC viability
Gerbich
55
resistant to enzymes (chymotrypsin), sensitive to protease (trypsin, pronase)
Gerbich
56
• Autoantibodios associated with severe autoimmune hemolylic anomia
Gerbich
57
deficiency Is associated with autoimmune disorders and susceptibility to bacterial meningitis
C4
58
specific allotypes have been linked to several autoimmune disorders, including rheumatoid arthritis and Graves' disease
C4
59
similar to Diego/Band 3, help anchor the membrane to the underlying cytoskeleton
GYPC and GYPD
60
in patients with protein 4.1 deficiency and hereditary elliptocytosis, it is decreased (75% normal)
GYPC and GYPD
61
rich in sialic acid can bind influenza virus
GYPC and GYPD
62
associated with marked elliptocytosis due to reduced membrane stability and deformability
Ge null (Leach) phenotype
63
associated with decreased RBC survival and hemolytic transfusion reactions
Cromer
64
DELETE
associated with decreased RBC survival and hemolytic transfusion reactions
65
Antigen of ISBT 021 associated with htr
anti Tc and anti Cr° have been implicated in HTR
66
in several cases, a transient loss of_________ was noted in the second and third trimesters with reappearance of the antibody following delivery
anti Cromer antibodies
67
can be inhibited by plasma, urine, and platelet concentrates
Cromer
68
• antibody reactivity is highly sensitive to pretreatment of RBCs with chymotrypsin and pronase, but not with other proteases
Cromer
69
protects cells from complement by promoting the decay of two C3 convertases: C4b2a and СЗЬВЬ
CD55/DAF
70
also a receptor for: • uropathogenic and intestinal E. coli strains bearing Afa /Dr and X adhesins • echovirus • coxsackie B virus
Cd55/daf
71
Null phenotype of ISBT 022
Helgeson Phenotype (Null Phenotype)
72
are resistant to proteases but are weakened by sulfhydryl reducing agents (AET, DTT)
• Knops antigens
73
ANTIBODIES • IgG, immune stimulation • Clinically insignificant • Reactive in DAT
Knops
74
complement regulatory protein can bind C3b/Cab immune complexes, promoting their degradation by factor 1 also enhances
CR1
75
could play a role in Leishmania, Legionella, and Mycobacterium infections
Cr1
76
• also binds P. (alciparum with rosette formation a clinical finding associated with severe malaria
cr1
77
78
show reduced P. falciparum binding and rosetting
SI (a-) RBCs
79
high frequency allele (99% white peoplo)
Inb
80
with the exception of AnW], In Ag are destroyed by proteases and AET
Indian
81
• can be clinically significant, with shortened RBC survival and transfusion reactions
Indian
82
are also inhibited by plasma, w/c contains soluble CD44
• Anti Indian
83
Resistant to Enzymes, sialidases, sulfhydryl reducing agents
Ok
84
ANTIBODIES • IgG • reactive in DAT • does not cause HDFN • decreased RBC survival
Isbt 024
85
Q on WBCs, is a leukocyte activation associated protein may participate in cell adhesion, tumorigenesis, and wound healing via stimulation of enzymes required for remodeling of the extracellular matrix
CD147
86
may also play a role in the trafficking of red cells out of the spleen
CD147
87
• Red cell aging is accompanied by progressive loss of CO|47, suggesting a possible role for CD147 in splenic removal of senescent red cells
CD147
88
89
90
Antigen of raph blood group system
• antigen • RAPH or Mer2
91
reactivity is sensitive to disulfide reducing agents and most proteases except papain
Raph
92
Can raph cause cause htr and hdfn
• no reports have described HDFN due to antiMER2 • can cause hemolytic transfusion reactions in some patients
93
a monocyte monolayer assay may be helpful in determining the clinical significance of antiMER2 antibodies
Raph
94
antigen is sensitive to proteases and DTT
JMH
95
Clinically insignificant although shortened RBC survival has been documented in some patients
JMH
96
Semaphorin proteins are implicated in cell signaling (SEMAZA)
JMH
97
in hematopoietic cells, can modulate cellular immunity via effects on T cells, monocytes, and natural killer (NK) cells
Semaphorin proteins
98
inhibits NK cell proliferation and is a negative regulator of T cell activation
Semaphorin
99
stimulates chemotaxis, secretion of inflammatory cytokines, and dendritic cell maturation in monocytes
Semaphorin proteins
100
a mombrane channel capable of transporting urea and glycerolon red cella, AQP3 may play a role in molaria infection
AQP3/Gil
101
plays a significant role in skin differentiation and hydration through regulation of glycerol content and metabolism
AQP3
102
from the red cell extracellular membrane may contribute to the pathology and severity of malarial infections
Internalization and loss of AQP3
103
in AQP3 is associated with decreased skin elasticity, poor wound healing, and eczema • Incressed AQP3 is observed in basal cell carcinoma
a decrease
104
can be modulated by inflammatory mediators, ultraviolet radiation, and topical glycerol
dermal AQP3 expression
105

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