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Flashcards in Unit 1 Deck (58)
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1
Q

Erythrocyte lifespan/amount of cells produced per day

A

120 days/ 2.5E9 cells per kg body weight per day

2
Q

Platelet lifespan/amount of cells produced per day

A

7 days/2.5E9 cells per kg body weight per day

3
Q

Neutrophil lifespan/amount of cells produced per day

A

7 hours/1.0E9 cells per kg body weight per day

4
Q

CFU-G

A

Colony Forming Unit for Granulocytes

5
Q

CFU-E

A

Colony Forming Unit for Erythrocytes

6
Q

CFU-M

A

Colony Forming Unit for Monocytes

7
Q

CFU-Meg

A

Colony Forming Unit for Megakaryocytes

8
Q

CFU-Eo

A

Colony Forming Unit for Eosinophils

9
Q

CFU-Baso

A

Colony Forming Unit for Basophils

10
Q

CFU-L

A

Colony Forming Unit for Lymphoid cells, Pluripotent Stem Cell, mother of all lymphoid cells

11
Q

CFU-LM

A

Colony Forming Unit for Lymphoid and Myeloid Cells, Multipotent stem cell

12
Q

CFU-GEMM

A

Colony Forming Unit for granulocytes, erythrocytes, monocytes, and megakaryocytes. Pluripotent Stem Cell, mother of all myeloid cells

13
Q

CFU-GM

A

Colony Forming Unit for Granulocytes and Macrophages

14
Q

GM-CSF

A

“Granulocyte-Macrophage Colony Stimulating Factor”. Is a multilineage growth factor for stimulating hematopoiesis

15
Q

IL-3

A

Interleukin 3. Is a multilineage growth factor for stimulating hematopoiesis

16
Q

G-CSF

A

“Granulocyte-Colony Stimulating Factor”. Stimulates CFU-G

17
Q

M-CSF

A

“Macrophage-Colony Stimulating Factor”. Stimulates CFU-M

18
Q

Erythropoietin (Epo)

A

Stimulates erythropoiesis, stimulates CFU-E, BFU-E.

19
Q

BFU-E

A

Burst Forming Unit-Erythroid. This is the progenitor to CFU-E.

20
Q

DCYTB

A

Duodenal Cytochrome B like Protein. Reduces Fe3+ to Fe2+ so that it can enter the duodenal epithelial cells

21
Q

DMT1

A

Divalent Metal Transporter. Allows Fe2+ to enter the duodenal epithelial cells

22
Q

Ferroportin

A

Allows iron atoms to leave the duodenal epithelium on the basolateral side

23
Q

Haephestin

A

Possibly oxidizes Fe2+ into Fe3+ on the basolateral side of the duodenal epithelium, so that the Fe3+ can bind to plasma apotransferrin

24
Q

What factors affect iron uptake in the duodenum?

A

Proteins and amino acids (increase absorption)
Vitamin C (increase absoprtion)
Phytates and Oxalates (components of food) (decrease absorption)

25
Q

Transferrin

A

iron transport molecule in the circulation

26
Q

Ferritin

A

Iron storage molecule, found intracellularly in splenic macrophages

27
Q

Hepcidin

A

protein made in the liver in response to high iron uptake, inflammation, and infection. When increased, it slows uptake of iron, decreases plasma transferrin iron concentration, and decreases RBC production. This mechanism is disrupted in anemia and hypoxia. When upregulated, it degrades ferroportin, increasing intracellular iron stores and also ferritin bound iron

28
Q

Erythrocyte concentration in blood

A

~5E6 per uL of blood

29
Q

Platelet concentration in blood

A

150-400,000 per uL of blood

30
Q

White Blood Cell concentration in blood

A

4,500-10,500 per uL of blood

31
Q

Neutrophil % in differential

A

40-60%

32
Q

Eosinophil % in differential

A

1-4%

33
Q

Basophil % in differential

A

0.5-1%

34
Q

Monocyte % in differential

A

2-8%

35
Q

Lymphocyte % in differential

A

20-40%

36
Q

Intrinsic Factor (IF)

A

Secreted by the GI tract, binds to Vitamin B12

37
Q

Pernicious anemia

A

Vitamin B12 deficiency anemia, caused by the autoimmune destruction of the gastric parietal cells that secrete intrinsic factor (IF)

38
Q

Normal CBC Value: Hemoglobin

A

14.3-18.1 g/dL

39
Q

Normal CBC Value: Hematocrit

A

39.2-50.2%

40
Q

Normal CBC Value: RBC Count

A

4.76-6.09E12 per L

41
Q

Normal CBC Value: Mean Corpuscular Volume

A

80-100 fL

42
Q

Normal CBC Value: Mean Corpuscular Hemoglobin

A

27.5-35.1 pg

43
Q

Normal CBC Value: Mean Corpuscular Hemoglobin Concentration

A

32-36 g/dL

44
Q

Normal CBC Value: Platelet Count

A

150-400E9 per L

45
Q

Normal CBC Value: Mean Platelet Volume

A

9.6-12.8 fL

46
Q

Normal CBC Value: Red Cell Distribution Width CV

A

11.7-14.2%

47
Q

Normal CBC Value: Red Cell Distribution Width SD

A

37.1-48.8 fL

48
Q

Normal CBC Value: NRBC %

A

0%

49
Q

Normal CBC Value: NRBC Abslute

A

0E9 per L

50
Q

Normal CBC Value: Whit Blood Cell Count

A

4.0-11.1E9 per L

51
Q

Normal CBC Value: Neutrophils Absolute

A

1.8-6.6E9 per L

52
Q

Normal CBC Value: Lymphocyte Absolute

A

1.0-4.8E9 per L

53
Q

Normal CBC Value: Monocytes Absolute

A

0.2-0.9E9 per L

54
Q

Normal CBC Value: Eosinophils Absolute

A

0.0-0.4E9 per L

55
Q

Normal CBC Value: Basophils Absolute

A

0.0-0.2E9 per L

56
Q

Hemoglobin A1

A

Predominant in adults, alpha2/beta2

57
Q

Hb F (fetal hemoglobin)

A

found in utero, alpha2/gamma2

58
Q

Heoglobin A2

A

Found in small amounts in adults, alpha2/delta2