Unit 1.2(ci) - Proteins, Protein structure, ligand binding and conformational change

Question 1

What does amino acid sequence determine?

Answer 1

Protein structure

Question 2

What are proteins made from?

Answer 2

Polymers of amino acid monomers

Question 3

what joins amino acids?

Answer 3

Linked by peptide bonds that form polypeptides

Question 4

What is the primary structure?

Answer 4

The order of amino acids in a protein

Question 5

What is the secondary structure?

Answer 5

The hydrogen bonding along the backbone of protein strands

Question 6

What structures are in secondary structure?

Answer 6

Alpha helices
Beta plated sheet
Turns

Question 7

The conformation of the tertiary structure is decided by

Answer 7

interactions between the R groups

Question 8

What is Quaternary structure?

Answer 8

Two or more polypeptide chains often linked together by di-sulphide bridges, or other various interactions

Question 9

What is a prosthetic group?

Answer 9

Additional non-protein structures that give the protein molecule it’s function

Question 10

Name the 5 bons/interactions that occur between R groups cause further folding of the polypeptide?

Answer 10

Hydrophobic interactions
Ionic bonds
Hydrogen bonds
Van Der Waals
Disulfide bridges

Question 11

An example of a prosthetic group is

Answer 11

Haem found in red bloods cells in haemoglobin responsible for oxygen carriage

Question 12

An example of a quaternary structure is

Answer 12

Haemoglobin

Question 13

What is tertiary structure?

Answer 13

The folding of polypeptide