UNIT 2: PHARMACODYNAMICS & DRUG RECEPTORS

Question 1

• Actions/effects of the drug on the body
• Determines the group in which the drug is classified and plays a major role in deciding whether a group is appropriate therapy for particular symptom or disease

Answer 1

Pharmacodynamics

Question 2

• Specific molecules in a biologic system with which drugs interact to produce changes in the function of the system
• Changes its function upon binding in such a way that the function of the biologic system is altered in order to have pharmacologic effec

Answer 2

Receptors

Majority are proteins which provide the necessary diversity and specificity of shape and electrical charge

Question 3

• Determine the quantitative relations between dose or concentration of drug and pharmacologic effects
• Selective in ligand-binding characteristics (respond to proper chemical signals and not to meaningless ones)

Answer 3

Receptors

Question 4

• Selective in choosing a drug molecule to bind to avoid constant activation by promiscuous binding of many different molecules
• Mediate the actions of both pharmacologic agonists and antagonists

Answer 4

Receptors

Question 5

It is the specific binding region of the macromolecule

High and selective affinity to the drug molecule

Answer 5

Receptor Site/Recognition Site

Question 6

True or False

Interaction between the drug and the receptor is the fundamental event that initiates the action of the drug

Answer 6

True

Question 7

What are the 4 Classification of Receptors

RETS

Answer 7

1. Regulatory Proteins
2. Enzymes
3. Transport Proteins
4. Structural Proteins

RETS

Question 8

• Best characterized drug receptors
• Mediates the action of endogenous chemical signals like neurotransmitters, autacoids and hormones

Mediates the effects of the most useful therapeutic agents

Answer 8

Regulatory Proteins

Question 9

It is Inhibited (or less commonly, activated) by binding a drug

E.g. dihydrofolate reductase, the receptor for methotrexate

Answer 9

Enzymes