Unit 3 Ch 12 Host Defenses 1 Flashcards

(52 cards)

1
Q

An infection in which the disease symptoms are influenced by more than one colonizer is termed an ___________ infection.

A

Polymicrobial

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2
Q

The total of all microbes found on and in a normal human is referred to as the human _________

A

Microbiome; biota

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3
Q

Organisms coming from somewhere in the same human host are considered _____________.
(Becoming established, Portals of Entry: To initiate an infection, a microbe entrees the tissue of the body by characteristic route, the portal of entry. Usually the skin or a mucous membrane.

A

Endogenous
Organisms coming from the outside of the body are exogenous.

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4
Q

Inflammation;
Disease;
Infection;
Pathology;
____________ can be characterized as any deviation from the healthy state.

A

Disease

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5
Q

A pathogen is a microbe whose relationship with its host is ____________ and results in infection and ________________.

A

Parasitic; disease

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6
Q

Exogenous microbes are likely to first encounter resistance from white blood cells that engulf and destroy pathogens by means of enzymes and antimicrobial chemicals.
These white blood cells are called: ___________

A

Phagocytes.

These cells ordinarily engulf and destroy pathogens by means of enzymes and antimicrobial chemicals

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7
Q

An infection in which the disease symptoms are influenced by more than one microbe is called a(n) ______________ infection.

A

POLYMICROBIAL; MIXED
The majority of infections are Polymicrobial, with contributions from more than one microbe, like the influenza cased by a virus and pneumonia (often caused by a bacterium). Influenza infection frequently leads to pneumonia.
- several types of skin infections are known to be caused by either Staphylococcus or Streptococcus species. When these 2 cultivated together with another common skin resident, MOraxella, both staph and strep increase their transcription of virulence factors. It is possible that the 3 of them together led to the disease symptoms.

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8
Q

Infection with a member of the normal biota, rather than an agent from the outside environment, is an example of an ______________ infection.

A

Endogenous infection

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9
Q

The 1st & 2nd lines of host defense are specific or nonspecific protections?

A

Nonspecific. Do not depend on specific acquisition.

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10
Q

Communication between separate fluid compartments of the body is conducted primarily through _____?

A

CAPILLARIES

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11
Q

A network of fibers & macrophages that permeates the tissues of the body is called the ____ ____ system.

MPS

A

Mononuclear Phagocyte System

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12
Q

Because it provides a passageway within & between tissues & organs, the ____ ____ system is intrinsic to the functions of the immune system.

MPS

A

Mononuclear phagocyte system

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13
Q

A compartmentalized network of vessels, cells, & protection against foreign materials is the ____ system.

A

Lymphatic

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14
Q

Major functions of the lymphatic system:

A
  1. Provides route for the extracellular fluid to return to the circulatory system proper
  2. drain off system for inflammmatory response
  3. render surveillance, recognition & protection against foreign materials through a system of lymphocytes, phagocytes & antibodies.
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15
Q

List the lymphoid organs

A

Spleen, Lymph nodes, Thymus

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16
Q

the flow of lymph goes what direction? Heart to extremities, or extremities to the heart?

A

from the extremities to the heart

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17
Q

Which cell types are produced in the red bone marrow?

A

Red blood cels, B-lymphocyte precursors, T-lymphocyte precursors

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18
Q

Although all blood cells originate in the bone marrow, only the ___ complete their maturation process here.

A

B-lymphocytes

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19
Q

Where T lymphocytes complete their maturation?

A

T lymphocytes migrate to the thymus to complete their maturation. Triangular structure two lobes in the lower neck region

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20
Q

List the major lymph nodes sites in the body.

3

A
  1. Armpit
  2. neck
  3. groin
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21
Q

Where are INGUINAL lymph nodes located?

22
Q

What are the lymph nodes located in the armpits called?

A

axillary nodes

23
Q

define: Hematopoiesis

A

the process by which all blood cells are formed in bone marrow.

24
Q

Define HEMOSTASIS

A

the plugging of broken blood vessels to stop bleading.

25
define HOMEOSTASIS
The maintenance of a stable internal environment
26
Generalized lymph node enlargement may indicate: an allergic reaction, or a systemic illness, or a localized infection?
a systemic illness
27
B & T cells belong to a group of leukocytes called: granulocytes, lyphocytes or monocytes?
Lymphocytes
28
What is the function of the SPLEEN?
filter old blood, removing worn out red cells from circulation.
29
Produced in the bone marrow, the cells are able to become any type of blood cell that is needed.
Pluripotential stem cells
30
Leukocytes (WBC) can be divided into 2 categories according to their staining patterns
1. granulocytes: have dark staining granules 2. agranulocytes: do not have granules, & have large nuclei.
31
# true or false? Monocytes & lymphocytes can be described as agranulocytes.
true. a type of leukocyte (wbc)
32
a phagocytic cell that has a high capacity for killing microbes & cleaning up dead cells: lymphocyte, macrophage, eosinophil or mast cell?
macrophage
33
List 3 granulocytic white blood cells
eosinophils, basophils, neutrophils
34
Which leukocytes are involved in immunologic responses to fungal and helminth worm infections, allergy & inflammatory reactions.
Eosinophils, a type of granulocyte
35
What are erythrocytes?
Red blood cells
36
What is the type of leukocyte, that are motile granulocytic cells that function in inflammatory events and allergies.
Basophils
37
Which one is the most common leukocyte and also a phagocyte? | Primary component of pus
Neutrophils
38
... are nonmotile cells htat are bound to connective tissue along capillaries. They release mediators such as histamine that trigger local inflammatory reactions & many allergic symptoms.
Mast cells
39
A group of leukocytes that include B, Natural Killer, & T cells?
Lymphocytes
40
A liquid connective tissue consisting of erythrocytes, leukocytes & platelets suspended in plasma is called: ## Footnote lymphatic system
whole blood
41
# wbc The largest phagocytic white blood cell derived from a monocyte which is involved with specific immune reactions is called a tissue.....
macrophage
42
# 1st line of defense A host barrier with an acidic pH & high fatty acid content that is inhibitory to many microbes is the ....
skin
43
What are the 4 mechanisms that play important roles in host defenses?
1. phagocytosis 2. inflammation 3. fever 4. antimicrobial producs
44
Identify the 3 main types of phagocytes: | neutrophils, dendritic cells, basophils, eosinophils, macrophages
neturophils, dendritic cells, macrophages
45
# 2nd line of defense which of the following processes are components of the 2nd line of defense: inflammation, fever, apoptosis, phagocytosis, antimicrobial proteins, sneezing, antibodies
Inflammation, Fever, Phagocytosis, Antimicrobial proteins
46
Small proteins naturally produced by white blood cells & tissue cells in response to viral infection are called: | complement proteins, pyrogens, or interferons?
Interferons IFN
47
What term describes the migration of white blood cells from the blood vessels into the tissue? | inflammation, chemotaxis, diapedesis, diffusion
Diapedesis
48
# Phagocytosis 1. Inflammation signals cause cells to migrate to the area
chemotaxis
49
# Phagocytosis 2. pattern recognition receptors identify and stick to foreign cells
Adhesion (PAMs) | pathogen associated molecular patterns - red flags
50
What molecule is found on the surface of microbes & serves as a red flag to phagocytotic cells? CAMP; ADP, PAMP, FERG?
PAMP Pathogen Associated Molecular Patterns
51
List the 6 steps of Phagocytosis briefly
1. Chemotaxis 2. Adhesion 3. Engulfment & phagosome formation 4. Phagolysosome formation 5. Destruction 6. Elimination
52
What term describes a small molecule secreted by cells to regulate & control immunity & inflammation? | Sebaceous secretions, messenger, cytokine, endotoxin?
Cytokine