Unit 3 (final 12/11) Flashcards
(97 cards)
Quantitative Genetics
The study of genetic basis underlying phenotypic variation among individuals
- continuous
- polygenic: one trait controlled by MANY genes
- effected by environmental factors
In a population of clones, how would their heights look?
Human height is controlled by 180 different genes, each with fairly small effects. Genotypes can yield a range of different phenotypes depending on the environment
To measure variation between phenotypes (Vp)
Subtract the smallest (height, weight, etc.) from the largest
Vp = Vg + Ve + C
- Vg: variation because of genes
- Ve: variation due to the environment
- C: unknowns (variation due to random events)
FORMULA PHENOTYPIC VARIATION
What is genetic heritability determined by?
The slope of the line
- no slope = no heritability
When is a trait heritable vs. non-heritable?
- non: when there is no GENETIC affect
- heritable when there’s no environment affect
- SLIGHTLY heritable: an environmental affect
VA = 1, VP = 1
Trait is heritable
- no environmental affect
VA = 0, VP = 1
Non-heritable
- no genetic effect
VA = 1, VP = 2
Slightly heritable
- environmental effect
Mid-offspring
Offspring average
Mid-parent
Parent average
If we KNOW the heritable of a trait, we can predict….?
How natural selection will affect it
R = h^2xs
Breeder’s equation
- R: the response to selection in the offspring generation (how the population will change in the future)
- S: the selection differential in the parent generation
- used to predict the response to a particular strength
How can we identify the genes/alleles that determine certain traits?
- experiment-based
- data-based
Experiment-based
Can only be done with species that can interbreed and have short lifespans
- inbreed, cross species, select specific phenotype you want, inbreed again, genome sequence
Data-based
Can only be done with hundreds of thousands of points (manhattan plot)
- because every change in DNA is technically a different allele, we can do this analysis for each nucleotide position in a genome
Can genetic drift, by itself, change the behavior of animals over time?
Drift, by itself, without natural selection, might fix one allele over the other. So, yes.
- more evident in smaller populations, though
What are the three major categories organisms invest their resources into?
1) growth
2) defense
3) reproduction
What three things determines fitness?
1) Survival to mating age
2) Fecundity
3) mating success
- if there’s lacking in any one area, but the other two are strong, fitness is still good
Higher investment in growth and defense leads to lower what?
Reproduction rates
Physiological senescence
A by-product of life: “rate-of-living” theory
- only true within species, not when comparing species
- faster metabolic rates = faster aging
- if lifespan is set by psychological constraints, we should expect no genetic variance in populations (for lifespans)
Evolutionary senescence: forged by evolutionary processes
In a long enough time line, everyone’s survival rate drops to 0
- mutation accumulation
- The process of the decline in fertility and decline in probability of survival with age.
Antagonistic pleiotropy
Occurs when the fitness consequence of the affected traits run in the opposite direction
- poses a major strain on evolution
Pleiotropy
Alleleic variation influencing more than one phenotype