Unit 36 Schizophrenia Flashcards

(34 cards)

1
Q

What is Psychosis?

A

Impairment in reality testing as evidenced by,

  • Hallucinations
  • Delusions
  • Thought disorganization
  • Grossly disorganized behavior
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2
Q

What is the DSM-IV diagnostic criteria for schizophrenia diagnosis?

A
  • At least two psychotic symptoms for one month
  • Social or occupational dysfunction
  • Six month duration of symptoms
  • Schizoaffective and other mood disorders have been excluded
  • Substance abuse and medical issues have been excluded
  • Developmental disorders excluded
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3
Q

What are combination of factors that probably cause schizophrenia?

A
  • Genetic predisposition
  • Biochemical dysfunction
  • Physiological factors
  • Psychosocial stress
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4
Q

What is the primary cause of premature death among people with schizophrenia?

A

Suicide.

10% die by suicide
40-55% have SI
20-50% attempt suicide

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5
Q

Substance abuse disorders occur in what percent of individuals with schizophrenia?

A

40-50%

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6
Q

What does schizophrenia disturb?

A

Affect

Perception

Thought Processes

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7
Q

What does schizophrenia lead to?

A

Severe deterioration of social and occupational functioning

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8
Q

What is the usual prognosis for schizophrenia?

A

A return to full premorbid functioning is not common.

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9
Q

What factors lead to positive schizophrenia prognosis’?

the negative would be the opposite

A
  • Good premorbid adjustment
  • Later age onset
  • Female gender
  • Abrupt onset of symptoms as opposed to gradual
  • Precipitated by a stressful event
  • Associated with mood disturbances
  • Brief duration of active phase symptoms
  • Good inter-episode functioning
  • Absence of structural brain abnormalities
  • No family hx of schizophrenia
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10
Q

What are the four progress stages of schizophrenia?

A
  1. Premorbid
  2. Prodromal
  3. Active Phase
  4. Residual Phase
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11
Q

Describe the first stage of schizophrenia.

A

The Premorbid stage:

  • Shy, withdrawn, poor peer relationships, doing poor in school, antisocial behavior
  • Neurobehavioral deficits.
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12
Q

Describe the second stage of schizophrenia.

A

The Prodromal stage:
(1 month - year before psychotic break)

  • Socially withdrawn
  • Evidence of peculiar behavior
  • Role function impaired
  • Personal hygiene neglected
  • Disturbances in communication, ideation, perception
  • Beginning to lose identity
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13
Q

Describe the third stage of schizophrenia.

A

The Active stage:
(1st psychotic break)
Psychotic symptoms are prominent in active phase
-Delusions
-Hallucinations
-Impairment of work, social relations, and self-care

Continuos signs of disturbance must persist for at least 6 months for Dx.

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14
Q

Describe the fourth stage of schizophrenia.

A

Residual stage

symptoms similar to those if prodromal phase, with flat affect and impairment of role functioning

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15
Q

What is downward drift hypothesis?

A

Disease that has genetic connection will run down the family line

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16
Q

What are predisposing factors of schizophrenia?

A
  • Genetic
  • Biochemical (excess dopamine, abnormalities in norepinepherine, serotonin)
  • Physiological (Brain abnormalities, histological changes, epilepsy, etc.)
17
Q

What are the 6 types of schizophrenia?

A

Disorganized schizophrenia: chronic with flat or inappropriate affect, silly bizarre giggling behavior

Catatonic schizophrenia: [Catatonic Stupor] extreme psychomotor retardation, mute, waxy flexibility
[Catatonic Excitement] extreme psychomotor agitation

Undifferentiated schizophrenia: Active signs of disorder, but symptoms do not clearly fall into one category

Paranoid schizophrenia: Most common in men, constantly on guard, ready for real or imagined threat, a pattern of behavior beginning in early adulthood with distrust and suspiciousness of others. Insensitive to others feelings, but HIGHLY sensitive to their own. Commonly seen schizophrenia.

Residual schizophrenia: hx of at least one episode of schizophrenia with psychotic symptoms, BUT NOW absence of delusions, hallucinations, disorganized speech, or other behavior, however continued evidence of disturbed thinking or beliefs

Schizoaffective schizophrenia: symptoms associated with mood disorder, either manic or depressive affect
(popular) high risk for developing schizophrenia

18
Q

What are the types of disorders?

A

Brief Psychotic Disorder: Lasts 1 month after extreme stressor, than back to normal functioning, sudden onset of psychotic symptoms following a severe stressor

Delusion Disorder: Grandiose, Jealous, Persecutory, Somatic, Erotomanic

Psychotic Disorder: caused by general medical condition; includes hallucinations and delusions attributed to medical condition (NOT dementia or delirium) usually neurological, endocrine, metabolic, etc

Induced Psychotic Disorder: Hallucinations and delusions attributable to the physiological effects of a substance (such as a Rx)

19
Q

What are the positive (the crazies) and the negatives (what they lack) symptoms of schizophrenia?

A

Positives: Hallucinations, Delusions, Poor ego boundaries, loose associations

Negatives:

  • apathy/anergia,
  • lack of motivation,
  • anhedonia (inability to feel pleasure),
  • social isolation,
  • blunted affect.
20
Q

What is mutism?

A

person who is normally capable of speech cannot speak in specific situations or to specific people.

21
Q

What is persecutory delusion?

A

delusional condition in which the affected persons believes they are being persecuted

22
Q

What is a word salad?

A

a confused or unintelligible mixture of seemingly random words and phrases, specifically (in psychiatry) as a form of speech indicative of advanced schizophrenia.

23
Q

What are neologisms?

A

a newly coined word or expression.

24
Q

What is clang association?

A

Clang associations are groupings of words, usually rhyming words, that are based on similar-sounding sounds, even though the words themselves don’t have any logical reason to be grouped together

25
What is waxy flexibility?
decreased response to stimuli and a tendency to remain in an immobile posture.
26
What are some communication guidelines for schizophrenia?
- Emphasize the hear and now - When understanding is not possible, just listening and accepting of the PT can be meaningful - Do not pretend to know that you understand the PT's communications when you are confused by the words or meanings - Place the difficulty of understanding on yourself, NOT the PT
27
What are therapy treatment options?
- Individual psychotherapy (reality-oriented with focus of decreasing anxiety and increasing trust) - Group therapy (outpatient with focus on social interactions) - Social Skills Training (role-play, feedback focus on ADL's) - Assertive Community Treatment (ACT)
28
What is prognosis generally closely related too?
-How well a person follows a drug treatment plan | Without meds 70-80% relapse over 12 months (Drugs taken continuously can reduce relapse to 30%)
29
What is the paradigm of thirds regarding prognosis and schizophrenia?
1/3 achieve significant and lasting improvement 1/3 achieve some improvement with intermittent relapses and residual disability 1/3 experience severe and permanent incapacity
30
What are the TYPICAL Antipsychotic Rx's, describe them, what do they treat, and what side effects do they/could they produce?
haloperidol (Haldol) fluphenazine (Prolixin) PO first then of side effects tolerated>>>decanoate injection-long lasting chlopromazine (Thorazine) prochlorperazine (Compazine) TYPICAL Antipsychotics are...traditional standard, neuroleptics, and major tranquilizers, also known as DRA's (dopamine receptor agonists) because they target dopamine type 2 (D2) receptors and reduce dopamine. -treats ONLY POSITIVE symptoms of schizophrenia -Produces motor side effects/extrapyramidal side effects which includes: dystonia (involuntary muscle contractions/twitching akathisia (restlessness) tardive dyskinesia (slow movements of face/body)-(can be permanent) parkinsonian-like syndrome (flat face, shuffle gait) Other life threatening side effect : Neuroleptic Malignant Syndrome ***
31
What is Neuroleptic Malignant Syndrome, the risk factors, and where could this side effect come from?
Rare, acute, life-threatening reaction to typical antipsychotic meds characterized by hyperpyrexia (very high fever), muscular rigidity, altered mental status, and autonomic dysfunction (hypertension, tachycardia, diaphoresis, incontinence) Risk factors: Older age, Female gender, rapid dose titration, presence of mood disorder
32
What medications are used to treat extrapyramidal side effects (EPS) of typical antipsychotic Rx's?
Antiparkinsonian/Anticholinergic agents: - diphenhydramine hydrochloride (Benadryl) - trihexyphenidyl (Artane) - benzotropine mesylate (Cogentin)
33
What are the ATYPICAL Antipsychotic Rx's, describe them, what do they treat, and what side effects do they/could they produce?
- clozapine (Clozaril) *high risk of agranulocytosis - quetiapine (Seroquel) - risperidone (Dispersal) - aripiprazole (Abilify) - They are serotonin-dopamine agonists (SRA's). Expensive Rx's. - They treat POSITIVE ANS NEGATIVE symptoms of schizophrenia. - They produce little to no motor side effects. Weight gain however
34
What is agranulocytosis?
low WBC