UNIT V - 16 Flashcards
infection
An infection is the entry of an infectious agent, a microorganism (organism only visible with a microscope), into the body that multiplies and disrupts tissue integrity.
an infectious agent VS a microorganism
1 enter
2 multiply
3 disrupt tissue integrity
microorganism
organism only visible with a microscope
kən-ˌta-mə-ˈnā-shən
cross-contamination
Careful hand hygiene is essential to prevent cross-contamination.
pathogens
Microorganisms capable of causing disease are called pathogens.
ˈflȯr-ə
normal flora
Nonpathogenic/ˌnän-ˌpa-thə-ˈje-nik / organisms that are prevalent on and in the body are called normal flora.
mə-ˈnä-pə-ˌlīz
monopolize
Normal flora accomplishes this by occupying receptor sites on cells, monopolizing the nutrients, and secreting substances that are toxic to other microorganisms.
transitive verb
: to get a monopoly of : assume complete possession or control of
ˌen-dō-ˈtäk-sən
endotoxins
Some pathogenic microorganisms produce harmful toxins and others release endotoxins. Endotoxins are responsible for the symptoms seen in diseases such as botulism /ˈbä-chə-ˌli-zəm/, tetanus /ˈte-tə-nəs/, diphtheria /dif-ˈthir-ē-ə /, and Escherichia /ˌesh-ə-ˈrik-ē-ə/ coli infection.
ˈpre-və-lənt
prevalent
Nonpathogenic organisms that are prevalent on and in the body are called normal flora.
1: generally or widely accepted, practiced, or favored : WIDESPREAD
2: being in ascendancy : DOMINANT
3:archaic : POWERFUL
prevalent noun
prevalently adverb
bacteria
Infectious Agents –> bacteria
Bacteria are single-cell microorganisms lacking a nucleus that reproduce from every few minutes up to several weeks.
aerobic /ˌer-ˈō-bik/ vs anaerobic /ˌa-nə-ˈrō-bik ˌan-ˌer-ˈō- /
Infectious Agents –> bacteria –> aerobic vs anaerobic
Aerobic bacteria need oxygen to grow and thrive.
Anaerobic bacteria grow only when oxygen is not present.
Gram staining
stain a specimen –> treat the specimen with a contrasting dye –> gram-positive VS gram-negative: more dangerous –> produce an endotoxin
A laboratory technique called Gram staining is performed to help classify the bacteria’s outer cell surface.
a contrasting dye /ˈdī /
The specimen to be tested for bacteria is placed on a slide, stained, and then treated with a contrasting dye; those retaining the stain are gram-positive, and those losing the stain and taking up the counterstain are gram-negative.
retain
1a: to keep in possession or use
b: to keep in one’s pay or service
specifically : to employ by paying a retainer
c: to keep in mind or memory : REMEMBER
2: to hold secure or intact
ˌhe-mə-ˈra-jik
hemorrhagic shock
hem·or·rhage ˈhem-rij
Many gram-negative bacteria are more dangerous than gram-positive bacteria because they may produce an endotoxin that can cause hemorrhagic shock and severe diarrhea and can alter resistance to other bacterial infection.
morphology /mȯr-ˈfä-lə-jē /
cocci / ˈkäk-sē /
bacilli /bə-ˈsi-ˌlī /
spirochetes /ˈspī-rə-ˌkēt/
Classification of bacteria according to their morphology (shape) places them into one of three main groups: cocci (round), bacilli (rod shaped), and spirochetes (spiral). Some grow in chains (streptococci /ˌstrep-tə-ˈkä-ˌkī/), some in pairs (diplococci /ˌdip-lō-ˈkäk-ˌsī /), and some in clusters (staphylococci /ˌsta-f(ə-)lō-ˈkä-ˌkī /).
culture
specimen is transferred to a medium –>sensitivity tests–>antibiotic
Final identification involves chemical testing of the bacteria by performing a culture.
ˌen-dō-ˈtäk-sən
endotoxin
A heat-stable toxin associated with the outer membranes of certain gram-negative bacteria that is released when the cells are disrupted.
ˈfa-gə-ˌsīt
phagocyte
Cells (e.g., macrophages) capable of ingesting particulate matter.
in·gest in-ˈjest
ingested; ingesting; ingests
transitive verb
: to take in for or as if for digestion
ingestible in-ˈje-stə-bəl adjective
ingestive in-ˈje-stiv adjective
ˌfa-gə-sə-ˈtō-səs
phagocytosis
The engulfing of microorganisms and foreign particles by phagocytes.
en·gulf in-ˈgəlf en- engulfed; engulfing; engulfs transitive verb
1: to flow over and enclose : OVERWHELM
the mounting seas threatened to engulf the island
2: to take in (food) by or as if by flowing over and enclosing
engulfment in-ˈgəlf-mənt en- noun
/ˈek-s(y)ü-ˌdāt/
exudate
Fluid in or on tissue surfaces that has escaped from blood vessels in response to inflammation and that contains protein and cellular debris.
spores
/ˈspȯr/
Oval bodies formed within bacteria as a resting stage during the life cycle of the cell; characterized by resistance to environmental changes (heat, humidity, or cold).
vector
/ˈvek-tər/
Carrier that transports an infective agent from one host to another, such as animals, insects, and rodents.
virulence
/ˈvir-ə-lən(t)s ˈvir-yə-/
Degree to which a microorganism can cause infection in the host or invade the host.
Characteristics that affect virulence are the ability to
(1) adhere to mucosal surfaces or cell walls,
(2) penetrate mucous membranes,
(3) multiply in the body,
(4) secrete harmful enzymes or toxins,
(5) resist phagocytosis (destruction by white blood cells [WBCs]), and
(6) bind with iron (essential to bacterial growth).
Upper respiratory tract (nose, mouth, throat)
Normal Flora of the Body
Corynebacterium/ˌkȯr-ə-(ˌ)nē-bak-ˈtir-ē-əm / species
Enterobacter/ˈent-ə-rō-ˌbak-tər/ species
Haemophilus/hē-ˈmä-fə-ləs / species
Klebsiella/ˌkleb-zē-ˈe-lə / species
Lactobacillus/ˌlak-tō-bə-ˈsi-ləs/ species
Neisseria/nī-ˈsir-ē-ə/ species
Staphylococcus/ˌsta-f(ə-)lō-ˈkä-kəs/ species
Streptococcus/ˌstrep-tə-ˈkä-kəs/ (viridans/ˈvir-ə-ˌdanz / group)
Streptococcus pyogenes (group A)
Various types of anaerobes/ˈa-nə-ˌrōb /
ˌpī-ə-ˈje-nik
pyogenic
adjective
pyo·gen·ic ˌpī-ə-ˈje-nik
: producing pus
pyogenic bacteria
also : marked by pus production
pyogenic meningitis