Upper GI Disorders Flashcards

1
Q

Types of vomiting in children

A

Vomiting with retching
Projectile vomiting
Bilious vomiting
Effortless vomiting

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2
Q

Phases of vomiting with retching

A

Pre-ejection phase:

  • pallor
  • nausea
  • tachycardia

Ejection phase:

  • retch
  • vomit

Post-ejection phase

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3
Q

Stimulants of vomiting centre

A
Enteric pathogens
Intestinal inflammation
Metabolic derangement 
Infection
Head injury
Visual stimuli
Middle ear stimuli
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4
Q
Differential diagnosis of case:
6 week old baby 
Vomiting after every feed
Vomit is large volume, projectile, millk or curdy 
Irritable and crying 
Not gaining weight
A

Gastroesophageal reflux
Overfeeding
Pyloric stenosis
Cows milk allergy

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5
Q

Presentation of pyloric stenosis (5)

A
Visible gastric peristalsis
Projectile non bilious vomiting 
Weight loss
Dehydration +/- shock
Electrolyte disturbance
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6
Q

Management of pyloric stenosis

A

Fluid resuscitation
Surgeon referral
-Ramstedts pyloromyotomy

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7
Q

Electrolyte disturbance in pyloric stenosis

A

Metabolic alkalosis (increase pH)
Hypochloraemia (decreased Cl)
Hypokalaemia (decrease K)

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8
Q

Typical age and gender of pyloric stenosis

A

Babies 4-12 weeks

Boys > Girls

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9
Q

Causes of bilious vomiting (6)

A

Intestinal obstruction

Intestinal atresia (in newborns only)
Malrotation +/- volvulus
Intussusception
Ileus
Crohns disease with strictures
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10
Q

Investigations for bilious vomiting (3)

A

Abdominal xray
Consider contrast meal
Surgical exploratory laparotomy

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11
Q

Most common cause of effortless vomiting

A

Gastro-oesophageal reflux

Self limiting

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12
Q

Other than gastro-oesophageal reflux other causes of effortless vomiting

A

Cerebral palsy
Progressive neurological problems
Oesophageal atresia +/- TOF operates
Generalised GI motility problem

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13
Q

Gastro-oesophageal reflux presentaion (9)

A

GI:

  • vomiting
  • haematemesis

Nutritional:

  • Feeding problems
  • Failure to thrive

Respiratory:

  • Apnoea
  • Cough
  • wheeze
  • Chest infection

Neurological:
-Sandifer’s syndrome

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14
Q

What is sandifer’s syndrome

A

gastro-oesophageal reflux disease with spastic torticollis and dystonic body movements

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15
Q

Investigations for gastrooesophageal reflux (6)

A
History and examination (normally enough)
Video fluoroscopy
Barium swallow 
pH study
Oesophageal impedance monitoring 
Endoscopy
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16
Q

What can a barium swallow detect

A
Dysmotility 
Hiatus hernia 
Reflux
Gastric emptying 
Strictures
17
Q

Problems of barium swallow

A

Aspiration

Inadequate contrast taken (NG tube)

18
Q

Pros and cons of pH study

A

Pro
-Detects acid reflux missed by barium

Con

  • Only detects acid reflux
  • May be uncomfortable for the child
19
Q

Pros and cons of endoscopy for detecting GOR

A

Pros

  • Best test for osophagitis
  • Can be combined with pH+impedance study

Cons
-Need anaesthetic

20
Q

Pros and Cons of trial of feeding test for GOR

A

Pro
-May be best discriminator if child needs surgery

Con

  • NG tube required
  • Needs 2-3 days in hospital
21
Q

Treatment for gastrooesophageal reflux

A

Feeding advice:

  • Thickeners for liquids
  • Appropriateness of foods (texture, amount)
  • Behavioural programme (oral stimulation, removal of aversive stimuli)
  • Feeding position

Nutritional advice:

  • Calorie supplements
  • Exclusion diet (milk free)
  • Nasogastric tube
  • Gastrostomy

Medical treatment:

  • Feed thickener (Gaviscon)
  • Prokinetic drugs
  • Acid suppressing drugs

Surgery:
-Nissen fundoplication

22
Q

Indications for surgery in GOR

A

Persistent:

  • Failure to thrive
  • Aspiration
  • Oesophagitis
23
Q

Chronic diarrhoea definition

A

4 or more stools per day
For more than 4 weeks

<1 week: acute diarrhoea
2-4 weeks: persistent diarrhoea
>4 weeks: chronic diarrhoea

24
Q

Causes of diarrhoea

A

Motility disturbance:

  • Toddler diarrhoea
  • IBS

Active secretion (secretory):

  • Acute infective diarrhoea
  • IBD

Malabsorption of nutrients (osmotic):

  • Food allergy
  • Coeliac disease
  • CF
25
Types of diarrhoea?
Osmotic Secretory Motility Inflammatory
26
Define osmotic diarrhoea
Movement of water into bowel to equilibrate osmotic gradient Normally a feature of malabsorption - Enzymatic defect - Transport defect Generally accompanied by macroscopic and microscopic intestinal injury Clinical remission with removal of causative agent
27
Define secretory diarrhoea
Classically associated with toxin production from vibrio cholerae and enterotoxigenic ecoli Intestinal fluid secretion predominantly driven by active Cl- secretion via CFTR
28
Define inflammatory diarrhoea
“Mixed” bag Malabsorption due to intestinal damage Secretory effect of cytokines Altered transit time in response to inflammation Protein exudate across inflamed epithelium
29
Red flag for organic pathology to diarrhoea
Nocturnal defecation
30
Difference between osmotic and secretory diarrhoea
Stool volume: Osmotic-Small Secretory-Large Response to fasting: Osmotic- stops Secretory- continues Osmotic gap: Osmotic- >135m0sm/l Secretory- <50m0sm/l Stool sodium: Osmotic- <70mmol/l Secretory- >70 mmol/l Stool potassium: Osmotic- <30mmol/l Secretory- >40mmol/l Stool chloride: Osmotic- <35mmol/l Secretory- >40mmol/l Stool pH: Osmotic- <5.5 Secretory- >6 Stool reducing substance: Osmotic- Positive Secretory- Negative
31
Fat malabsorption stools (steatorrhoea) causes
``` Pancreatic disease (due to lack of lipase) Eg CF ``` Hepatobiliary disease Eg chronic liver disease, cholestasis
32
What is coeliac disease
Gluten-sensitive enteropathy
33
Presentation of coeliac disease (7)
``` Abdominal bloatedness Diarrhoea Failure to thrive Short stature Constipation Tiredness Dermatitis herpatiformis ```
34
Screening tests for coeliac diseases
Serological screens: - Anti-tissue transglutaminase - Anti-endomysial - Anti-gliadin - IgA Duodenal biopsy Genetic testing -HLA DQ2, DQ8
35
According to ESPGHAN guidelines what are the criteria for coeliac disease
Symptomatic Anti TTG >10 times upper limit of normal Positive anti endomysial antibodies HLA DQ2, DQ8 positive If not all present diagnose with biopsy If all present dont need biopsy
36
Treatment for coeliac disease
Gluten free diet Risk of small bowel lymphoma if continue to have gluten