Upper & Lower GI Flashcards
(122 cards)
1
Q
What are important questions to ask patients presenting with abdominal pain?
A
- SOCRATES
- Bowel
- function, regularity, consistency
- flatus, blood/mucus
- N+V
- blood/bile
- Systemic symptoms
- Pyrexia weight loss
- Previous operations
- Last E+D
2
Q
What are other non GI causes of abdominal pain?
A
- Abdominal Aortic Aneurysm (AAA)
- Myocardial Infarction
- Lower Respiratory Tract infection
3
Q
What do these blood results suggest in someone presenting with sudden onset epigastric pain that is sharp, constant and radiates to the back?
A
Suggests Pancreatitis - obstructive picture
- Bilirubin, ALP and ALT are all elevated: suggesting a gallstone cholicystic picture
- Amylase is significantly elevated
- suggests that the common bile duct may be blocked as well
4
Q
What are the most common causes of Pancreatitis?
A
I GET SMASHED
- Idiopathic
- Gallstones
- Ethanol (alcohol)
- Trauma
- Steroids
- Mumps (re-infection in adulthood)
- Autoimmune
- Scorpion Venom
- Hyperlipidaemia/hypothermia/hypocalcaemia
- ERCP (Endoscopic retrograde cholangiopancreatography)
- Drugs
5
Q
What measures are used in the Modified Glasgow Score for Pancreatitis? What does it show?
A
P- PO2 <8
A- Age >55
N- Neutrophilia WCC >15
C- Ca+ <2mmol/L
R- Renal Function- Urea >16mmol/L
E- Enzymes- AST LDH > 600, AST >200
A- Albumin <32g/L
S- Sugar- >10mmol
- It is a marker of how severe the patients condition is
- 1 = mild, 2 = moderate, >3 = severe
6
Q
What imaging is carried out in suspected pancreatitis?
A
- USS - detects gallstones and pancreatic oedema
- CT - more sensitive - can rule in our out necrosis/ collections
7
Q
What does a severe scoring on the modified Glasgow score for pancreatitis indicate?
A
- Score 3 or more within 48hrs of onset = SEVERE
- Rx in HDU/ITU
- 10-50% Mortality for SEVERE PANCREATITIS
8
Q
What is the general management for a 60 y/o man with a PO2 <8 , severe epigastric tenderness, dehydrated, non distended good BS, localised guarding and a raised amylase
A
- ABCD approach
- Analgesia, IV fluids, +/- O2, cathetere + fluid balance
- NBM +- NGT, +/- detox regime +/- anti-emetic
- Further interventions
- MRCP/ERCP
- HDU/ITU potentially
9
Q
What causes 80% of pancreatitis?
A
- Gallstones
- Alcohol
10
Q
What are complications of pancreatitis
A
- Hypovolaemic shock
- Haemorrhagic pancreatitis
- Gret Turner’s/ Cullen’s signs
- Pseudocyst formation
- pressure effect
- Infected necrosis
- ARDS (acute respiratory distress syndrome)
- SIRS (systemic inflammatory response syndrome)
- T2DM
- Chronic pancreatitis
- Multiple organ failure
- Death
11
Q
What does this chest radiograph show? +/- indicate
A
- this is free air underneath the diagram
- suggestive of bowel perforation
- this image is taken erect
12
Q
What are the complications of a peptic ulcer
- management
A
- Perforation
- Erosion through mucosa into
peritoneal cavity - Surgical emergency
- laparotomy
- Severe haematemesis
- Erosion into a vessel
- Medical emergency
- Endoscopy → laparotomy if fails
13
Q
What does this radiograph show?
A
- free gas (black) and fluid (darker grey) around the edge of the liver
- may be due to a bowel perforation
14
Q
What are risk factors for peptic ulcer disease?
A
- H.Pylori
- NSAIDS
- Smoking
- Spiced foods
- Blood group O
15
Q
What are the different presentations for Gastric vs Duodenal ulcers?
A
Gastric
- M:F – 3:1
- Peak 50 years
- 45% assoc H Pylori
- Exacerbated by food
Duodenal
- M:F – 5:1
- Peak 25-30 years
- 85% assoc H Pylori
- Relieved by food
16
Q
What is Murphys sign?
what does it indicate?
A
Asking a patient to inhale deebly whilst pallpating on the right costal margin
- a positive sign will illicit pain
- and this is indicative of acute cholicystits (inflammation of the gallbladder)
17
Q
What is Rovsing’s sign?
What could this indicate?
A
When you press down on left lower quadrant of the abdomen and it illicits pain on the right lower quadrant
- could indicate appendicits
18
Q
What is the gold standard for imaging the gallbladder?
A
USS
19
Q
What are the Risk factors for gallstones?
A
- Fat
- Female
- Fertile
- Fourties
20
Q
How would you manage someone presenting with gallstones (cholelithiasis)?
A
Conservative
- IV fluids, analgesia then Anti-biotics, low fat diet send them home
Surgically
- IV fluids, analgesia, chelcystectomy
21
Q
What are complications of gallstones?
A
- Empyema/mucocoele
- Gallbladder perforation (rare)
- Gallstone ileus
- gall stone perforates small bowel
- Pancreatitis
22
Q
What is Ascending Cholangitis?
A
Infection of the bile duct, usually caused by ascending bacteria from the duodenum
most commonly Escherichia coli, Klebsiella, Enterobacter, Pseudomonas, and Citrobacter
23
Q
How do people present with Ascending cholangitis?
A
- Charcot’s triad
- (RUQ pain, Jaundice, Pyrexia)
- Reynold’s pentad
- Charcot’s+ Shock + confusion
- as well as RUQ pain, Jaundice, Pyrexia
24
Q
What are causes of ascending cholangitis?
A
- Gallstones
- Strictures (benign/balignant)
- Malignancy (CBD/ pancrease)
- Iatrogenic - ERCP
- Bacterial infection
25
What is Biliary Colic?
Acute gall bladder pain when gallstones transiently blocks the cystic duct and the gallbladder contracts
* caused by fatty foods
* patiently is systemically well
26
What is Dysphagia?
Causes
Difficulty swallowing
* Malignancy
* Neurological
* Stroke, Parkisons, Myasthenia Gravis
* Pharngeal pouch
* Pharngitis
* Radiotherapy
27
What is a pharngeal pouch (Zenker's diverticulum)?
Occurs when part of the pharyngeal lining herniates through the muscles of the pharyngeal wall. This occurs mainly in older people.
causes dysphagia
28
Whats is the investigation pathway for someone presenting with dysphagia?
what would each pathway show?
Bloods: FBC, U&E, LFT
Distingiuish - **Oesopha**geal or **Oropharn**geal
**Oesopha**geal
* Endoscopy and biopsy
* Stricture,
* Oesphagitis,
* Dysmotility
**Oropharn**geal
* Videofluoroscopic swallowing assessment
* neurological disease: Pseudo/Bulbar palsy, Myasthenia gravis
29
What are Oesophageal cauees of dysphagia?
* Stricture,
* Benign: Peptic, Fibrous ring
* Malignant: Carcinoma of stomach/ oesophagus, Extrinsic compression
* Oesophagitis
* Peptic
* Candidiasis
* Eosinophilic
* Dysmotility
* Achalasia
* Non-speciifc motility disorder
30
A patient presents with weightloss and difficulty swallowing with a “sticking” feeling in their throat. They have on endoscopy and they get his image what is your top differential and management?
Oesophageal cancer
Management
* Staging: CT, laparoscopy, EUS, PET
* Surgical: Oesophagectomy
* Medical: Chemotherapy radiotherapy
* Palliative: Stenting
* complications
8th most common cancer worldwide
2x more common in males
80% occur in \>60 y/o
10-15% survival rate
31
What type of Oesophageal Cancers are there?
* Squamous Cell Carcinoma (more common in far east 90%, 25-40% in the UK)
* Tends to affect upper 2/3
* Smoking
* Alcohol
* Adenocarcinoma (more common in west, 60-75% in the UK)
* Tends to affect lower 1/3
* GORD
* Barrett’s oesophagus
* Obesity
32
What are causes of Gord, and what are its complications?
* 10-20% of population affected
* Dyspepsia/heartburn/indigestion
* decrease Lower oesophageal tone
* Can be associated with Hiatus hernia
* Can lead to Barrett’s oesophagus
33
What is Barret's Oesophagus?
Barrett's esophagus is a condition in which **tissue that is similar to the lining of your intestine replaces the tissue lining your esophagus**. People with Barrett's oesophagus may develop a rare cancer called **esophageal adenocarcinoma**
34
What is the treatment for GORD?
* PPI: (eg omeprazole)
* wouldn't use omeprazole in patients on hyponatremic medication
* H2: antagonist (eg ranitidine)
* Alginates: (eg Gaviscon)
35
What is seen in this image
Investigations, and treatment
* Oesophageal dysmotility syndrome
* decreased peristalsis
* increased LES tone
* Often painful
* resulting in bird peaked stricture
* Ix- Barium swallow, manometry, bx
* Rx- Ca channel blockers, dilatation,
Heller myotomy, POEM NOTES
36
What are potential differentials for the circular lesion on this image?
Keloid scar
Umbilical Hernia
Sister Mary Joseph umbilical nodule (metastatic cancer nodule)
37
What types of gastric cancer are there?
Gastric adenocarcinoma 74.6%
Gastric lymphoma 24%
* Polypoid carcinoma; Large & bulky(25%)
* Ulcerating deep,penetrating tumours that can extend through all walls(25%)
* Superficial spreading - early gastric cancer(10%) (Japanese)
* Linitis Plastica(10%) Leather bottle
* Advanced(30%)
38
What are risk factors for gastric cancer?
* Chronic gastritis
* Hypochlorhydria
* _Infection with H.pylori_
* Previous partial gastrectomy – stump carcinoma
* Diet
* _Nitrites_
* smoked & salted foods
* pickled vegetables.
* Smoking
39
What are the differentials with someone with this history and examination
* PC: 4 weeks of constipation and then loose stool
* HPC: 1 stone weight loss 6 months
* +abdominal distension. FIT test positive
* No pain, no vomiting, Previously BO regularly od.
* PMH: IHD, hypercholesterolaemia
* Looks comfortable
* Pale conjunctivae
* No abdominal tenderness
* Hugely distended abdomen, quiet BS
* PR- empty, No blood , No melaena
* OBS:
* HR110, BP 110/80, RR 28, Sats 96%, Afebrile
* Colorectal malignancy
* Large bowel obstruction
* Small bowel obstruction
* Ischaemic bowel
* IBD
* IBS
40
What does this image show given this history
* PC: 4 weeks of constipation and then loose stool
* HPC: 1 stone weight loss 6 months
* +abdominal distension. FIT test positive
* No pain, no vomiting, Previously BO regularly od.
* PMH: IHD, hypercholesterolaemia
Left colon cancer with liver metastases
41
What is the management of Colorectal cancer?
* Initial: ABCDE
* NBM
* IV fluids
* Analgesia
* ±O2
* ±Anti-emetic
* Fluid balance (consider catheter)
* Correct electrolytes
* Urgent CT – CAP
* Stoma nurse (based on surgery needs)
* Further: Endoscopy
* Expediated v planned laparotomy eg impending perforation, peritonitis
* Lap v open
* Daylight hours v out of hours
42
What is the epidemiology of colorectal cancer?
50,000 cases a year in the UK
4th most common cancer in UK
after Breast, Lung, Prostate.
2nd most common cause of cancer death
15,000 deaths / year in UK (44/day)
Survival improving despite incidence rising
Overall survival 60% surgery all stages
Majority over 70 years old (60%)
SURVIVAL IS **GOOD** Women/Men
43
What are risk factors for Colorectal cancer?
* Male
* Increasing age
* Smoking
* Alcohol
* Obesity
* Family history
* Inflammatory bowel disease
44
What are the criteria that make up the Two Week Rule (2WR) criteria in the UK
* Over 40 with UNEXPLAINED weight loss
* Over 50 with rectal bleeding
* 60 or over with iron deficiency anaemia
* 60 or over with a change in bowel habit
* Palpable mass abdominally or rectally
* Additionally population screening tests
* Positive FOB / FIT Test
45
What is FOB/FIT test?
* Population screening tests
* (every 2 years in UK 50-74yrs)
* **FOB – faecal occult blood test**
* Gold standard
* However picks up any blood in faeces- eg also from food
* Needs 3 faeces samples from 3 separate bowel movements
* **FIT – faecal immunochemical test** is an improved tool from FOB
* More sensitive ( can system cope with increased demand v earlier detection is better for patient)
* Can measure HOW much human blood
* in stool rather than just Y/N
* Increases uptake as 1 sample needed v 3
46
What tests are done to investigate for bowel cancer?
* Luminal sample (Tissue)
* Gold standard – **colonoscopy** – RISKS Flexible sigmoidoscopy LIMITED STUDY OGD – IDA or obstructive symptoms
* Radiological
* CT / MRI / USS / PET CT
* ‘Virtual colonoscopy’ – CT Colonography
* Other – Blood tests – CEA, LFT, FBC
* **FIT/FOB**
47
What is the CEA Test
it's a blood test that looks for the Carcinoembryonic Antigen which is a tumor marker produced in the colon and rectum
* CEA is a glycoprotein produced in foetal GI tissues involved in cell adhesion. production stops at birth
* normal levels in adults 2-4ng/ml
* normal level in smoker \<5ng/ml
* A rising CEA can indicate progression or recurrence of tumour
* Once tumour is removed CEA levels return to normal in 3/12 weeks
* It's not specific as it can be raised in
* smokers
* cancers of prostate, ovary, non cancerous breast diseases
* lung, thyroid, emphysema
* liver, cirrhosis
48
What are the risks of colonoscopy?
Bleeding Perforation
Missed pathology
Acute kidney injury
Risks of sedation (elderly, frail, aspiration)
49
What are the risks of Radiological investigaions
Perforation with CT colonography
Cancer - radiation dose
missed pathology - diverticular disease
50
What Screening is available for bowel cancer?
* UK NBCSP – National Bowel Cancer Screening Programme
* Age 50 to 74 every two years (previously 60-74)
* FOB – faecal occult blood test
* Likely being replaced nationally with FIT
* Faecal immunochemical test
* ASYMPTOMATIC PATIENTS!!!
* Variable uptake 50-60%
* Lower in socially deprived areas
51
What are the various types of polyps?
* Hyperplastic – benign
* Tubular adenoma \<5% malignant. 70% of adenomas
* Villous adenoma 30-40% malignant. 10% polyps
* Tubulovillous adenoma 25% malignant. 20% of polyps
52
What does a big colonic polyp indicate?
* size does not always indicate malignancy
* \<1cm - 1% chance of malignancy
* \> 2cm - 40% chance of malignancy
53
What is the treatment of a big colonic polyp?
* TEMS – transanal endoscopic microsurgery
* TAMIS – transanal minimally invasive surgery
* Open surgery/ Laparoscopic/ Robotic
* **_Colonoscopic endoscopic surgery (image)_**
* **EMR** (Endoscopic Mucosal Resection) allows for **removal** of **polyps** confined to the mucosa often in a piecemeal fashion while
* **ESD** (Endoscopic Submucosal Dissection)aims for enbloc resection for lesions extending into the submucosa. The most serious complications include bleeding, perforation and ?incomplete resection.
54
What is an Abdominoperineal resection/ excision?
The sigmoid colon and entire rectum and anus is removed
The surgeon uses the descending colon to create a permanent stoma → _colostomy_ allows faeces to exit the body
The anal area will be stitched up and permanently closed
55
What are the basic principles of bowel surgery?
* Take out the cancer
* Leave a healthy margin of tissue
* Make a join that has a good blood
* supply that is tension free
* or make a stoma
* Take away the blood supply to the segment of colon that had the cancer
* Following the blood supply are the lymphatics,
* all removed as one envelope together
56
What are the risk of surgery in colerectal cancer?
* Infection
* Bleeding
* DVT/PE
* Injury to Bowel/Bladder/
* Ureteric/Vascular Injury/Pelvic Nerves
* Anastomotic leak (5-20%)
* MI/CVA/Resp failure/AKI
* RECURRENCE
* Further procedure / Treatment
* Chronic pain
* UK mortality for elective colorectal surgery 2.2% at 90 days
57
What are non-surgical considerations for the patient post colerectal surgery?
* Infection
* Bleeding
* DVT/PE
* Injury to Bowel/Bladder/
* Ureteric/Vascular Injury/Pelvic Nerves
* Anastomotic leak (5-20%)
* MI/CVA/Resp failure/AKI
* RECURRENCE
* Further procedure / Treatment
* Chronic pain
* UK mortality for elective colorectal surgery 2.2% at 90 days
58
What staging is used in colorectal cancer?
TNM
Dukes - ABCD stage
59
What Neoadjuvant therapy is available
* Chemotherapy
* Radiotherapy
* Usually both (one sensitizes the other)
* Goals
* Downstage
* Curative
* Palliative
* Reduce risk recurrence
* FOLFOX – 5FU oxaliplatin (oral 5FU = capecitabine)
* FOLFIRI – 5FU and Irinotecan
* Short course 3 months. Long = 6 months
* MDT….MDT…..MDT….
60
What surveillance can be given following treatment?
5 years of follow-up
combination of colonoscopy, CT and CEA
clinical review
61
What does this history suggest? - why?
## Footnote
PC: Generalised abdo pain and vomiting
HPC: Sudden onset 12 hours ago, Colicky, non-radiating, 4 x vomit green/yellow fluid. 7/10. BNO and no flatus
PMH: 3x C-section, HRT, open appendicectomy 20 years ago for perforated appendix
Small bowel obstruction
the vomiting is an early sign
62
What would an abdominal radiograph show in Small bowel obstruction?
Valvuae conniventes
central loops/ air-fluid levels
63
What are causes of small bowel obstruction?
* Adhesions (60%)
* Neoplasms (20%)
* Hernias(10%)
* Crohn’s (5%)
* Volvulus (3%)
* Pseudo-obstruction
* Foreign bodies (eg GS ileus)
* Ischaemic strictures
* Intussusception (children)
* Radiation enteritis
64
What is the management of small bowel obstruction?
* Initial
* ABCDE
* Anti-emetic
* +- O2
* FLuid balance +\_ catheter
* Analgesia
* Urgent CT
* Further
* Surgical: Hernia repair, Adhesiolysis, Resection
65
What differentials would you take from this history and examination?
You are asked to see an 82 year old retired army officer, living in a retirement home who was sent to A&E by his GP. The patient reports a 3 day history of severe generalised abdominal pain, during which time his abdomen has become grossly distended
* Admits to taking a ‘few tablets of codeine here and there for aches and pains’
* Has not opened bowels since the start of this episode – no flatus
* Nausea, no vomiting
* Anorexia
* PMH: RTHR, no previous abdo surgery or hernias
* SH: Smokes a pipe
Examination
* Grossly distended
* Generally tender
* No masses/scars/hernias
* Tinkling bowel sounds
* No systemic Sx
* PR: empty rectum, no blood/stool
* Obs:
* HR 100, BP 100/70, RR 18, Sats 88%, Afebrile
Large bowel obstruction
Small bowel obstruction
Ischaemic bowel
Pseudo-obstruction Ogilvie's syndrome
Ileus
66
What is the modality of this image and what pathology does it show?
Sigmoid voluvulus
67
What are the characteristics of a sigmoid volvulus
* Distended oval gas shadow loop on itself to give a _coffee bean sign_
* Haustra
* In a sigmoid volvulus, the bowel rotates on its mesentery → strangulated obstructed bowel
68
How would you manage a patient with sigmoid volvulus?
* Initial:
* ABCDE
* NBM & NGT (bowel rest)
* IV fluids
* Analgesia
* ±O2
* ±Anti-emetic
* Fluid balance (consider catheter)
* Correct electrolytes
* Urgent CT
* Further
* Careful decompression with a Flexi sigmoidoscope
* laboratory if there's evidence of ischaemia
69
What are the causes of large bowel obstruction?
* Neoplasms (60%)
* Diverticulitis (20%)
* Caecal/sigmoid volvulus (5%)
* Hernias
* IBD
* Adhesions
* Constipation/faecal impaction
* Pseudo-obstruction
* MND/MS/spinal cord lesions
* Hirschprung’s disease-children
70
What are the differentials for this presentation?
## Footnote
Ms F, 22Y
PC: RIF pain
HPC: Sudden onset RIF pain, Constant ache, Non-radiating, nausea- no vomiting and anorexia, Worse when moving/coughing, 8/10. Periods irregular
PMH: nil
O/E: Tender RIF +++, Localised guarding, rebound tenderness
* Appendicitis
* Gynae:
* Ectopic
* Ovarian torsion
* Ruptured ovarian cyst
* Mesenteric adenitis
* Hernia
* Meckel’s diverticulum
* Caecal tumours/diverticulum
* UTI
* Renal colic
* Testicular torsion
* Gastroenteritis
* Cholecystitis/Pancreatitis
71
What are the common characteristics of Appendicitis?
* occurs at any age
* uncommon \<4 or \> 80
* peak 13-35 y/o
* can be associated with diarrhoea
* classically central abdominal pain radiating to the right iliac fossa
* Would be present with **Rovsings sign**
* **McBurney's point** would be the area of most tenderness
* site of the base of the appendix
72
What is the management for appendictis?
* Initial:
* ABCDE
* NBM
* IV fluids
* Analgesia
* Fluid balance (consider urinary catheter
* ±O2
* ±Anti-emetic
* **Antibiotics**
* Further
* Lao/open appedndicetomy
73
What are complications of an appendectomy?
* Perforation
* Abscess - RIF/pelvic
* RIF -appendix' mass (asherent caecum/omentum)
* Sepsis
* Death
74
What are the differentials for this presentation?
## Footnote
Mrs L, 72Y
PC: LIF pain
HPC: 2/7 intermittent LIF pain, worsening, now constant, diarrhoea and nausea.
PMH: IBS, AF, HTN
O/E: Tender LIF, Localised guarding
* Diverticulitis
* IBD
* Ischaemic colitis
* Gastroenteritis
* Colon Ca
* Gynae
* Renal Colic
* Pseudomembranous colitis
75
What is the management of diverticulisis?
* Initial:
* ABCDE
* **Abx**
* NBM
* IV fluids
* Analgesia
* ±O2
* Fluid balance (consider catheter
* Anti-emetic
* Consider further imaging
* Further:
* Colonoscopy
* Rx complications
* Hartmann’s Procedure if perforation
76
Explain what Diverticular disease is and it's charchteristics
* Acquired outpouchings of colonic mucosa and overlying connective tissue through the colonic wall
* Tend to occur along lines where colonic arteries penetrate
* Peak age 50-70
* common over the age of 30
* **Diverticulosis**- Presence of diverticulae, usually asymptomatic but can cause IBS symptoms
* **Diverticulitis**- Inflammation of a diverticulum à not necessarily due to bacteria.
77
What are the complications of diverticular disease?
* Abscess
* Fistula
* between the bowel and the bladder
* Stricture
* Perforation
* Haemorrhage
* Sepsis
78
What are the differentials of for thsi presentation?
* 38yr old financial analyst
* Recently quit smoking
* Presents with bloody diarrhoea for 4 weeks
* BO x8 /day
* Nocturnal episodes
* Feels unwell
* Temp 38, HR 92, BP 120/70, Mild abdominal tenderness
* Ulcerative Cholitis
* Chrons disease
* Infection
* Diverticulitis
* Colerectal cancer
* IBS
* Coeliac disease
* any other cause of diarrhoea + haemorrhoids
79
What investigations would you do for this presentation?
* 38yr old financial analyst
* Recently quit smoking
* Presents with bloody diarrhoea for 4 weeks
* BO x8 /day
* Nocturnal episodes
* Feels unwell
* Temp 38, HR 92, BP 120/70, Mild abdominal tenderness
* Bloods
* CRP/ESR
* U&E
* FBC
* Coeliac serology
* Stool
* Culture
* Calprotectin
* marker of bowel inflammation with high sensitivity
* used in young people IBD vs. IBS
* not a good detecting cancer
* predictor of relapse in IBD
* Colonscopy + biopsies
80
What are the two types of IBD's?
give features of the diseases
_Ulcerative Cholitis_
* relapsing and remitting inflammotry disease of the colonic mucosa
* effects the colon only
* always starts distally in the rectum and is continous
* typically presents 20-40y/o
* smoking is protective of UC
_Crohn's disease_
* chronic inflammatory disease that is characterized by transmural granulomatos inflammation affecting any part of the GI tract
* most commonly effects the terminal ileu, (70%)
* “skip lesions” unaffect section of bowel inbetween
* effects the dull thickness of the bowel wall
* perforating
* fistulating
* stricuting
81
What are the signs and symptoms of UC & Crohn's
82
What are the histopathological difference between UC and Crohns disease?
_Ulcerative Colitis_
* Chronic inflammatory cells
* Mucosal only
* Crypt abscesses
* Crypt distortion
* Goblet depletion
_Crohn's disease_
* Chronic inflammatory cell
* Full wall thickness invasion
* lymphoid hyperplasia
* Granulomata
83
What is the aetiology of IBD?
* Familial/Complex genetic
* Luminal antigens
* Diet
* Bacteria [MICROBIOME]
* Mucosal Barrier Dysfunction
* Smoking
* Makes Crohn’s worse
* Quitting may make UC worse
84
What is the management of IBD?
* Admit for clinical assessment A to E
* AXR ?
* at each stage of assessment rule out Toxic mega-colon
* CT abdo/pelvis
* Medical management including Thrombo-prophylaxis
* IV steroids +/- rectal steroid enemas & Adcal D3
* Anti-inflammatory
* Immunosuppression
* Biologics
* Inform surgical team / stoma nurses
* Inform patient re possibility of needing surgery
85
What is used to assess the severity of Ulcerative colitis?
Truelove and Witts Criteria
86
What is the timeline of treatment for the management of IBD?
* At day 3 there must be significant improvement or treatment must be escalated.
* repeat AXR
* repeat Flexi sigmoidscopy
* Immunospression: Ciclosporin or Biologic Infliximab
* Surgical review/ Stoma therapist review
* At day 7 must also have a response or escalate to surgery
_Response at day 3 or 7_
* Reduce oral steroids - prednisolone
* continue Adcal D3 whilst on prednisolone or budesonide
* establish Maintenance therapy
* 5-Amino Salicylic acid (5-ASA) - anti-inflammatory
* Cyclosporing and Azathioprine/ Mercaptopurine (immunosuppressive medication)
* Biologics used to treat IBD: inflicimab, Asalimumab, Vedolizumab, Golimumab
* Chimeric monoclonal antibodies used to treat auto-immune diseases
* given as slow injection every 6/8 weeks
* Anti-TNF, Anti-IL, Anti-Integrin
87
What surgery is given to IBD patients with no response to medical management after 7 days?
* Subtotal colectomy + ileostomy (stoma)
* colectomy saple sent to confirm UC or Crohns
* rectum left in-situ
88
What are the indications for surgery in Ulcerative colitis?
* Fulminant colitis wth toxic dilation/ perforation
* Colitis unresposneive to medical therapy
* Steroid dependence
* Dysplasia/malignancy
89
What curative surgery is done in UC?
* Ileostomy or Ileo-anal pouch operation
* Neorectum reservoir made from doubled back ileum to stimulate rectum
90
What are some problems of a Ileo-anal pouch?
* Pouchitis
* Ciffitis
* Poor pouch function
* Dysplasia
* Fertility
* What if it's Crohn's
* ileum is most commonly effect (70%)
91
What is the long term outlook for IBD patients?
* Relapsing remitting
* Frequent steroid-requiring flares → azathioprine
* Steroid dependent or unresponsive to medication (chronic active)→ biologics or surgery
* After 8-10 years regular screening colonoscopy to rule out cancer
* 0.3%/year 20% at 30yrs
92
What are addtional problems for chidren with IBD?
* Growth
* Development
* Bone health
* Nutrition
* Body Image / relationships
* Education / Career choices
* Disease progression
* Early control imperative
93
What imaging is done for Crohns?
MRI
Small bowel follow through
Capsule endoscopy (if there are no stricture)
94
What are the clinical presentations of complications of Crohn's disease?
* Obstruction
* Fistula formation
* To skin (especially wounds)
* Peri-anal
* To another hollow organ e.g. another bowel loop, bladder, vagina
* Malabsorption / weight loss
* Anaemia
95
What are the complications of treatment for IBD with steroids?
* **Weight gain and abnormal fat distribution (buffalo hump, moon face)**
* **Thin skin, easy bruising, striae, acne, red face**
* Hirsutism or hair loss
* Osteoporosis
* **Proximal myopathy**
* Menstrual irregularities
* Hypertension
* Hypokalaemia (and therefore alkalosis)
* Impaired glucose tolerance
* Depression / Mental disturbance / psychosis
* (In children – growth and developmental delay)
96
What are the complications of treatment for IBD with Immunosupression drugs: **Azathioprine/Mercaptopurine**
* Myelotoxicity
* Hepatotoxicity
* Pancreatitis
* Gastrointestinal intolerance
* Flu-like symptoms
* Susceptibility to infection – esp. viral
* Lymphoma
* Skin cancer
97
What are the complications of treatment for IBD with Biologics:
## Footnote
**Infliximab/ Adalimumab**
* Allergic reactions / anaphylaxis
* Local reaction to injection
* Reactivation of latent infection esp. TB
* Susceptibility to infection esp. opportunistic
* Lymphoma
* Other cancers: lung, skin
98
What are the complications of treatment for IBD with Anti-inflammatory 5-ASAs
* Safe
* Occasionally worsen diarhoea
* Very rare;y assocaited with renal impairment
99
What are some surgical complications to consider in treating IBD
* Resect **minimal amount possible**
* Extensive resection does not reduce relapse
* At risk of repeat resections and short bowel
* Possible to do strictureplasty rather than resect?
* Anastomosis (especially in the acute situation) at high risk of break-down / fistula formation → protect with defunctioning stoma
* Patients on steroids and with nutritional compromise are at particularly high risk
100
What are the general complications of IBD
* Nutritional
* Short bowel
* Anaemia
* Osteoporosis
* Cancer risk
* Thromboembolism
* Social
* Sexual
* Family planning
* Psychological impact
101
What are extr-intestinal manifestations of IBD?
* Arthritis
* Mouth ulcers
* Erythema nodosum
* Pyoderma gangrenosum
* Scleritis
* Anterior Uveitis
102
What is Primary Sclerosing Cholangitis?
Symptoms signs, treatment, associated complications
* Progressive scarring/stricturing of bile ducts. Hepatitis, Liver fibrosis, Cirrhosis and Liver necrosis
* Associated with UC
* Symptoms and signs – RUQ pain, Rigors, Night sweats, Wt loss, Jaundice, Hepatosplenomegaly
* **Treatment = Liver transplant**
* Associated with higher risk of bowel cancer in UC and a high risk of cholangiocarcinoma
103
What is important to consider in the nutrition of IBD patients?
* maintian a diet that is suffiecnt to maintian
* growth, pregnancy, bone health, healing
* to induce remission in Crohn's disease
* normal diet replaced by forumal feed
* this is as effective as steroids in paediatric studies
* minimal side effects
* improves nutrion & supports growth
* to maintain remision in Crohn's disease
* supplemental forumal feed/part replacement
104
What can be done to prevent stoma bag leakages?
* Woder esdhesive section
* Warm bags stick better than cold bags
* bags can be filled with gas very quickly- adhesive can be peeled back to release pressure without complete removal
105
What types of stomas are there?
* Permanent or temporary
* Ileostomey
* Colostomy
* Double barreled, Loop, End
depends on the indication
106
What are the indications for an ileostomy, how would you recognise one?
_Indications_
* divert from a large bowel obstruction
* to allow bowel rest: fistula, perforation, anastomosis
* uncontrolled IBD, UC/ CD
_Recognition_
* usually in the right inguinal region
* more spouted, to protect skin
* contents of the bag: liquid stool
* surrounding skin may be irritated
107
What types of Ileostomies are there?
* **End ileostomy.** This is a permanent ileostomy with one opening from the ileum to the skin
* e.g. ulcerative colitis leading to pancolectomy
* **Loop ileostomy**. This can be a temporary ileostomy with a proximal opening of small bowel and a distal opening of small bowel. Sharing a posterior wall.
* Usually to protect a distal anastomosis
* **Double Barreled stoma**. This can be a temporary ileostomy with a proximal and distal opening. Separate tubes.
108
Why woould you need to rest an anastomosis?
* patients who are at high risk for anastomotic leak
* eg, malnourished, high-dose steroids, DM
* who have an intestinal anastomosis \<5 to 7 cm from the anal verge (low anastomosis below the peritoneal reflection)
* hemodynamically unstable (eg, trauma, sepsis, perforation)
109
What are the indications for a Colostomy? How would you recognise one?
_Indications_
* divert froma large bowel obstruction
* allow bowel to rest due to fistula, perforation, complicated diverticulitis
* trauma
_Recognition_
* in the left illiac fossa region
* more flush to the skin
* more solid formed stool matter
110
What types of colostomies are there?
when would they be done?
**Permanent end colostomy**- In the case of a large resection (e.g. tumour, diverticulitis) and unable to join remaining bowel or the patient is not fit for a second operation.
**Temporary end colostomy**- In the case that pathology needs to settle or patient needs to be ‘fitter’ before the second operation.
**Loop colostomy-** share a posterior wall- to protect a distal anastomosis usually.
111
What is a Urostomy/ when are they indicated?
how would you recognise one?
_Indications_
* created following a cystectomy (urinary bladder removal)
* drains urine from the ureters to skin and into the stoma bag
* connection between the ureters and skin → ‘ileal conduit’ as it is made from a piece of the ileum
_Recognition_
* located in the right illiac fossa
* bag will contain urine
112
What is considered when positioning a stoma?
* it is away from the site of the incision
* away from bony prominences
* positioned where it can be strenghted by the rectus sheath
* away from the belt lin
* accessible to the patient
*marked pre=operatively with the help of the stoma nurse*
113
What are stoma complications? Immediate, Early, Late
_Immediate (days)_
* GA complications
* Necrosis
* Bleeding
* Retraction
* Infection
* Psychological
_Early (weeks)_
* Stenosis/ obstruction
* High output – dehydration/electrolyte imbalance
* Retraction
* Skin irritation
* Infection
* Psychological
_Late (months)_
* Stenosis/ obstruction
* Parastomal hernia
* Retraction
* Prolapse
* Fistula formation
* Skin irritation
* Infection
* Psychological
114
Explain a Hartmann's operation
where a necrotic or non-viable section of the bowel is removed with the distal section being closed and left in the abdomen (rectal stump) and the more proximal section is made into and end colostomy
*There is usually the intention to reverse the proccedure*
115
What is the _initial_ approach to a patient with the following stoma site?
What does it show?
* ABCDE approach
* Take a full history
* Perform a thorough, abdominal examination → then focus on the stoma *always take of the stoma bag*
* Perform digital exammination of the stoma
Shows a nectotic stoma
116
What are the causes of a necrotic stoma?
Insufficient blood supply for various reasons…. global or local hence A → E
* Poorly vascularised piece of bowel (mesentery has been stripped /twisted or the trephine (skin hole) is too small)
* Poorly perfused systemically. Need to assess the extent of the necrosis.
* If extensive devascularisation of the small bowel then stoma needs revising
* If limited to the stoma mucosa (blood blister) (usually the case) then simple observation.
however the insufficient perfusion may lead to future stricture/ stenosis
117
What could be the cause of a non-functioning ileostomy in a patient with a history of Crohns, abdominal pain and vommiting
* Stenosis
* can occur in ealry postop period but is more likely to develop months later
* Stoma fistula
* Entercutaneous fistula?
* Constipation
* Adhesions
* Parastomal hernia
* New onset of malignancy
118
What is an important link between Crohn's disease and stomas?
Crohn's causes trasnmural inflammation and can lead to stenosis and/or fistual formation
119
What constitutes a High output stoma?
what are possible complications and the accompanying management?
* A stoma with an output of more than 500ml in 24 hours
* There is a risk of dehydration and electrolyte disturbance
* IV fluids, correct electrolytes
120
What pathology is seen in this image?
Parastomal Hernia
## Footnote
weakness in the abdominal wall → protrusion of the bowel
121
What is this pathology and how is it managed?
* Small prolapse can be initially managed conservatively :
* Cool compresses and application of an osmotic agent (sugar) to reduce oedema, followed by manual reduction of the prolapse and application of a binder.
* BUT will recur…
* Large prolapse, recurrent small prolapse or prolapse producing ischemic changes, or mucosal irritation and bleeding.
* Requires surgical intervention- resection and refashioning of stoma.
122
What are risk factors , complications and managment for a Parastomal hernia?
_Risk factors_
* Obesity
* Cough
* Not fashioning stoma in rectus
_Complications_
* incarcerated
* stuck and unable to be pushed back in
* obstructed
* strangulated → needs repair
_Management_
* reduce the hernia (difficult and not very successful)
* put mesh over the hernia
* hernia belt
* as long as it's not incarcerated
* recreate a new stoma
