Urinary System - Embryology Flashcards

(32 cards)

1
Q

what abnormality is shown here?

A

horseshoe kidney

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2
Q

What is in the adult urinary system?

A

Kidneys

  • Nephron
  • Collecting duct
  • Calyces and pelvis

Ureter

Bladder

Urethra

Blood supply

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3
Q

what are the 3 parts of the mesoderm and what do they form?

A
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4
Q

what is shown here?

A

Lateral folding of embryo

(seen in cross section)

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5
Q

___________ mesoderm forms the Urinary and reproductive systems (GU system)

A

Intermediate

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6
Q

what process is being shown here?

______________ connecting to the yolk sac

A

Head and tail fold

Vitelline duct

Out pouching at the back is what is going to be the start of the urinary system and is called the allantois

(seen in midsagittal sections)

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7
Q

what is Allantois?

A

Allantois is an outpouching of endoderm at the hindgut that extends into the body stalk

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8
Q

what is the Cloaca?

A

Definition: (noun) The cloaca is the single posterior opening for a bird’s digestive, urinary and reproductive tracts and is used to expel feces and lay eggs

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9
Q

Allantois and cloaca:

The cloaca divides to form ______ (GI tract) and anteriorly the ________ _____.

The mesonephric duct drains into the _______ _____

The urogenital sinus later forms the ______ _______ and its caudal end forms the ________

Allantois obliterate once umbilicus forms and develops into the _______

A

Allantois and cloaca:

The cloaca divides to form rectum (GI tract) and anteriorly the Urogenital Sinus.

The mesonephric duct drains into the urogenital sinus

The urogenital sinus later forms the urinarybladder and its caudal end forms the urethra

Allantois obliterate once umbilicus forms and develops into the urachus​

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10
Q

_ sets of kidneys develop sequentially during nephrogenesis

A

3

(nephrogenesis - describes the embryologic origins of the kidney)

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11
Q

Early in the Week _ the intermediate mesoderm in the neck region of the embryo becomes the __________

A

4

pronephros

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12
Q

Pronephros are made up form what 2 parts?

A

Pronephros = pronephric duct + rudimentary pronephric tubules

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13
Q

Pronephric duct drains into ______

A

cloaca

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14
Q

Pronephros are the _____________

A

Rudimentary kidneys (lower fish e.g. lamprey)

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15
Q

Do the pronephros degenerate and if so when?

A

In humans, the pronephros mainly degenerates by Week 5 (except the pronephric duct)

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16
Q

What forms the Mesonephros and when?

A

Mesonephros = Intermediate mesoderm in trunk region, late Week 4

17
Q

_________ duct now becomes the mesonephric duct

18
Q

___________ ______ develop and drain into the mesonephric duct

A

Mesonephric tubules

19
Q

Mesonephros functions as the ______ for approx. 4 weeks.

20
Q

what comes after Mesonephros?

A

The metanephros or the definitive kidney

21
Q

When do the metanephros start to forma nd when do they function

A

The metanephros starts to develop from about Week 5, but starts to function around Week 9

22
Q

what does the developemnt of the metanephros consist of?

A
  • A ureteric bud that develops off the mesonephric duct
  • Metanephric mesoderm (the most caudal part of the intermediate mesoderm)
23
Q

what happens to the mesonephos?

A

Much of the mesonephros will be incorporated into the developing gonad

(Undifferentiated cells from the yolk sac migrate in to form the spermatogonia/oogonia)

The mesonephric tubules become the rete testis

The mesonephric duct becomes the vas deferens (tiny muscular tube in the male reproductive system that carries sperm from the epididymis to the ejaculatory duct)

(In females the mesnephros becomes the ovary but the tubules and mesonephric duct degenerate)

24
Q

Metanephros – Ureteric bud – describe its further development

A

The ureteric bud undergoes repeated branching at its distal end

The stalk becomes the ureter, the expanded cranial end becomes the renal pelvis

The first 4 generations of branches become confluent to become the major calyces

The next 4 generations form the minor calyces

The remaining generations form the collecting tubules

25
describe the developemnt of the nephron
The ureteric bud and the metanephric mesoderm reciprocally induce each other Green = ureteric bud Brown formed form metanephric mesoderm
26
Same of different? Nephron vs Uriniferous tubule
Nephron = Renal corpuscle + PCT + Loop of Henle + DCT Uriniferous tubule = Nephron + Collecting duct
27
Nephron develops from _________ \_\_\_\_\_\_\_\_\_ Collecting duct and calyces, pelvis, ureter develop from the _________ \_\_\_
Nephron develops from **_metanephric mesoderm_** Collecting duct and calyces, pelvis, ureter develop from the **_ureteric bud_**
28
describe the ascent of the kidneys
Kidneys initially lie on either side of the bladder and in the developing pelvis. Appears to “ascend” into the abdomen mainly due to differential growth of lower body inferiorly away from kidneys Kidneys come to lie in upper abdomen (T12-L3) Hilum rotates from ventral to medial (~90degrees) Ascent stops when they come in contact with adrenal glands Segmental breakdown and reform of vascular supply during ascent
29
Anomalies in development
30
in summary: 1. ______ and _____ = urinary bladder and urethra 2. Intermediate mesoderm develops into the rudimentary __________ in neck (week 4), __________ in trunk region (week 5 to 9) with a duct and tubules. ____ drains into cloaca
in summary: 1. **_Allantois_** and **_cloaca_** = urinary bladder and urethra 2. Intermediate mesoderm develops into the rudimentary **_pronephros_** in neck (week 4), **_Mesonephros_** in trunk region (week 5 to 9) with a duct and tubules. **_Duct_** drains into cloaca
31
in summary: 3. Ureteric bud grows out of the caudal end of the ___________ duct… 4. …and branches to form the renal pelvis, calyces and ________ duct 5. The ______ bud and the __________ mesoderm reciprocally induce each other
in summary: 3. Ureteric bud grows out of the caudal end of the **_mesonephric_** duct… 4. …and branches to form the renal pelvis, calyces and **_collecting_** duct 5. The **_ureteric_** bud and the **_metanephric_** mesoderm reciprocally induce each other
32
in summary: 6. The kidneys “rise” due to differential growth of ____________ structures and acquires ___ blood vessels 7. Rotates so that the hilum faces \_\_\_\_\_\_\_\_
in summary: 6. The kidneys “rise” due to differential growth of **_abdominopelvic_** structures and acquires **_new_** blood vessels 7. Rotates so that the hilum faces **_medially_**