Urology Flashcards

(155 cards)

1
Q

What are the common causes of haematuria?

A

Nephritic syndrome
Renal, ureteric or bladder or prostate cancer
Trauma
Renal and ureteric and bladder stones
TB
Pyleonephritis
Schistosomiasis
Urethritis
Strictures
BPH
Epidymitis
Menses

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2
Q

What are the risk factors for haematuria?

A

Above 60
Smoking
Worked with paint, dyes, metals or petroleum
Recurrent UTI
FHx of bladder cancer
Schistosomiasis prevalent

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3
Q

How might you examine a patient with haematuria?

A

Abdo - tenderness or masses, urinary retention
DRE - prostate

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4
Q

What are the primary Investigations for haematuria?

A

Blood tests, urinalysis, midstream urine sample for culture, upper tract imaging and flexible cystoscopy

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5
Q

What other symptoms should be assessed with haematuria?

A

Rigours
Fever
lethargy

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6
Q

What results in renal colic?

A

Acute ureteric obstruction - usually calculus or blood clots

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7
Q

What can acute ureteric obstruction lead to?

A

Acute renal failure or pyonephrosis

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8
Q

What type of pain Is renal colic?

A

From loin to groin
Peristalytic movement

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9
Q

How do you respond to pyonephrosis.

A

Urological emergency. Decompress

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10
Q

What is the common presentation of renal colic!

A

Sweat, pale, restLess, N+V

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11
Q

How is upper urinary tract obstruction diagnosed?

A

CT or USS
Diuretic renography (MAG3)

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12
Q

How is an upper urinary tract drained?

A

Nephrostomy
JJ stent
Anagelesia
High fluid intake
ESWL
PCNL

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13
Q

What are the causes of stress UI?

A

Weakness in pelvic floor muscle - post partum, constipation, obesity, post menopausal, pelvic surgery

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14
Q

What are the causes of urge UI?

A

Neurogenic caused - infection, malignancy or idiopathic, medication - cholinesterase inhibitors

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15
Q

Mixed UI

A

Stress and urge

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16
Q

What are the causes of overflow UI!

A

Prostatic hyperplasia, spinal cord injury or congenital defects

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17
Q

What are the causes of continuous UI?

A

Ectopic ureter or bladder fistula

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18
Q

What investigations should be performed for incontinence?

A

Bladder diaries
Midstream urine dipstick - infection or haematuria
Post void bladder scans
Urodynamics assessment
Cytoscopy

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19
Q

What is the conservative management of UI?

A

Stress: Pelvic floor muscle training and Duloxetine (ssri)
Urge - anti muscularis drugs and bladder training

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20
Q

What is the surgical management of UI?

A

Urge - botulinum toxin A injection, percutaneous sacral nerve stimulation, augmentation cystoplasty (whereby a detubularised segment of bowel is inserted into the bladder wall to increase bladder capacity), or urinary diversion via ileal conduit.
Stress - tension free vaginal tape, open colposuspension (involving elevation of the bladder neck and urethra through a lower abdominal incision), intramural bulking agents, or an artificial urinary sphincter

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21
Q

How should a testicular lump be inspected?

A

the Site, Size, Shape, Symmetry, Skin changes, and any Scars present.

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22
Q

Obstructive uropathy

A
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23
Q

How should you palpate a testicular lump?

A

Tenderness, Temperature, Transillumination, Consistency, Attachments, Mobility, Pulsation, Fluctuation, Irreducibility, Regional lymph nodes, and the Edge.

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24
Q

What investigations should be taken for a scrotal lump?

A

USS, blood tests (tumour markers - LDH, AFP, beta -hCG)

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25
What are the possible causes of testicular lump?
Extra testicular - hydrocoele (fluid between layers of tunica vaginalis, transilluminate), varicoele (abnormal dilation of pampnifork plexus, bag of worms), epididymal cysts (fluid filled sacs from epididymis), epididymitis(usually STI), inguinal hernia (into scrotum via external inguinal ring entering inguinal canal or hesselbach) Testicular - cancer - painless lumps, does not transillumiate, irregular, testicular torsion (twisting of testis on spermatic cord, bell clapped deformity - high attachment of tunica vaginalis, orchitis
26
What is a medical emergency!
Testicular torsion
27
What is the treatment for testicular cancer?
radical inguinal orchidectomy
28
what parts of a history are important for scrotal lumps?
time of onset associated sx previous episodes
29
how should a scrotal lump be inspected?
Site Size Shape Symmetry Skin changes Scars
30
how should a scrotal lump be palpated?
1) Palpate testis, epidiymis and vas deferens 2) Tenderness, temperature and transillumination 3) CAMPFIRE - Consistency, Attachments, Mobility, Pulsation, Fluctuation, Irreducibility, Regional lymph nodes and Edge
31
what is the first line investigation for a scrotal lump?
USS of scrotum
32
which investigations are required if testicular cancer is suspected?
NO BIOPSY - risk of seeding cancer on other factors and histopathology of testis following orchidectomy LDH and AFP and beta-hCG can be used
33
what are the differentials for scrotal lump?
extra testicular - hydrocoele, varicocoele, epidiymal cysts, epididymitis, inguinal hernia testicular - tumour, torsion, benign lesions, orchitis
34
hydrocoele - definition, management
abnormal collection of peritoneal fluid between the visceral and parietal parts of tunica vaginalis - painless fluctuant swellings, transilluminate..can get painful and require surgery - can be congential requiring ligation - or idiopathic or secondary to trauma, infection or malignancy..USS
35
varicoele - definition, management, red flag signs
abnormal dilation of the pampiniform venous plexus within spermatic cord..bag of worms, disappear lying flat found on left side usually - spermatic veins drain into left renal vein (smaller) compared to IVC on right - can result in infertility, testicular atrophy...semen analysis red flag signs = acute, R sided, remain lying flat - embolisation and ligation of veins, but if asymptomatic - no treatment
36
epidiymal cysts
benign fluid filled sacs arising from epididymis, will transilluminate no tx
37
epididymitis
inflammation of the epididymis unilateral acute onset pain, swelling, erythematous, fever, dysuria, haematuria, urethral discharge pain relieved on elevation of testis - prehn's sign STI or enteric organisms - oral abx and analgesia
38
inguinal hernia
passes into scrotum via external inguinal ring(through inguinal or hesslebach's first)..run alongside spermatic cord cannot palpate its superior surface and cough may exacerbate swelling
39
testicular tumour
painless lumps in tesis firm, irregular mass, do not transilluminate USS, tumour markers, radical inguinal orchidectomy + chemo
40
testicular torsion
twisting of testis on spermatic cord occludes testicular and cremasteric arteries..ischaemia and testicular infarction acute, unilateral, N+V may be associated with bell clapper deformity - high attachment of tunica vaginalis resulting in rotation tender, swollen, loss of cremasteric reflex EMERGENCY - surgical exploration..untwisted and return of vascularity then orchidectomy if infarcted
41
give 4 examples of benign testicular lesions
benign leydig cells tumours, sertoli cell tumours, lipomas, fibromas
42
orchitis
inflammation of testis main causes - viral (mumps) rest and analgesia
43
which investigations are required for acute scrotal pain
urine dipstick - and requires microscopy culture sensitivity urethral swab - STI blood test - FBC, U and E, CRP USS of scrotum
44
what are some causes of referred scrotal pain?
branches of genitofemoral and ilioinguinal nerve - anterior and pudendal and posterior femoral cutaneous nerve - posteriot ...ureteric stones
45
what is the biggest complication of acute-on chronic urinary retention?
post obstructive diuresis
46
what are some causes of urinary retention?
BPH, urethral strictures, prostate cancer, UTI, constipation (compress urethra), anti-muscarinics or spinal/epidural, peripheral neuropathy, MS or parkinsons (Upper motor neurone diseases)
47
what are the clinical features of urinary retention?
acute suprapubic pain unable to micturate palpable, distended bladder PR exam - prostate associated fevers or lethargy - infective
48
which investigations are required for acute urinary retention?
post void bladder scan - volume of retained urine FBC, CRP, UE after catheterisation - a catheterised specimen of urine assessed for infection USS - hydronephrosis
49
hydronephrosis
as intravesicular pressure increases and becomes too high, counteracts the anti reflux mechanism of bladder and ureter ---> hydroureter and hydronephrosis...deranged renal function, renal scarring, CKD
50
how is BPH treated?
tamsulosin - alpha receptor antagonist, relaxes smooth muscle at bladder neck and within prostate
50
what is the most common cause of chronic urinary retention in men?
BPH, or urethral strictures or prostate cancer
51
what are the most common causes of chronic urinary retention in women?
pelvic prolapse - cystoele, rectocele or uterine prolpase, pevlic masses such as large fibroids
52
what is the management of chronic urinary retension?
high post void volumes - post obstructive diuresis monitoring long term catheter treat underlying cause
53
what is the most common complication of chronic urinary retention?
UTI due to urinary stasis, or CKD
54
what is the difference between visible and non visible haematuria?
visible - naked eye non visible - urine dipstick or urine microscopy
55
what are some differentials for haematuria?
UTI,renal cancer, renal calculi, prostate cancer, BPH
56
how is the degree of haematuria quantified?
pink v dark red presence of clots or not timing in the stream - if terminal (at end), then bladder irritation but if total - bladder or Upper tract
57
what are important questions in the history for haematuria?
associated sx - LUTS, fever, rigor, suprapubic or flank pain, weight loss, recent trauma smoking - urological malignancies, industrial work - bladder cancer, or recent travel (schistosomiasis)
58
which examinations are required for haematuria?
DRE, abdo, external genitalia
59
which initial investigations are required for haematuria?
urinalysis - presence of nitites and leukocytes - infection FBC, UE, clotting PSA urinary protein levels and referral to nephrology
60
what are the nice guidlines for urgent referral to urological service for haematuria?
>45 unexplained visible without UTI or visible that persists are successful treatment of UTI >65 unexplained non visible haematuria, dysuria, raised WCC
61
what is the gold standard investigation for assessing lower urinary tract?
flexible cystoscopy, with local anaesthetic for further assement or follow up for proven malignancy
62
waht is the management of haematuria?
treat underlying cause require insertion of three way catheter for wash out and irrigation and evacuation of clots
63
what are the differentials for LUTS and some exacerbating factors to ask in hx?
men - BPH, female - UTI, others - bladder cancer, prostate cancer, destusor muscle weakness, pelvic floor dysfunction, chronic prosatitis, urethral strictures, external compression from pelvic tumours exacerbated - fluids at night, alcobol, caffeine
64
what are the sx of voiding and storage luts?
voiding - hesistancy or straining in micruturion, poor flow, terminal dribble, feeling of incomplete emptying storage - increased frequency, nocturia, increased sense of urgency to urinate, urge incontinence
65
what are the clinical features of LUTS?
hx - voiding or storage associated sx - visible haematuria, suprapubic discomfort, colicky pain medication hx - anticholinergics, antihistamines and bronchodilaters - exacerbate examinations - DRE, external genitalia score - international prostate symptom score - impact of luts on QoL in men
66
what investigations are required for LUTS?
post void bladder scan and flow rate bladder diary urinalysis then culture FBC, UE, PSA specialist - urodynamic studies, cytoscopy (recurrent infections or haematuria), upper uri imaging via uss or ct
67
what is the conservative management of LUTS?
regulate fluid intake and avoid exacerbating factors voiding sx - urethral milking technique (manually emptying bulbar urethra of residual urine) or double voiding (passing urine and waiting before passing urine again) pelvic floor exercises bladder training techniques
68
what is the pharmacological treatment of LUTS?
anticholinergics (oxybutynin) - for overactive bladder..relax bladder muscle by opposing parasympathetic control of contraction or Beta-3 adrenergic agonist(mirabegron) as this causes relaxation of detrusor muscle alpha blockers (tamsulosin) or 5 alpha reductase inhibitors (finasteride) for BPH, relaxes prostatic muscle loop diuretics (furosemide) - prevent nocturia
69
what are the complications of untreated LUTS?
infection, renal and bladder caliculi - stagnation of urine bladder wall distension - overflow incontinence renal failure, vilateral hydronephrosis
70
define renal cysts
simple - well defined outline, homogenous features complex - thick walls, septations, calcification, risk of malignancy
71
what are the risk factors for renal cysts?
age smoking hypertension male
72
define polycystic kidney disease
mutation in PKD1 OR 2 - multiple renal cysts forming in affected individuals
73
what are the clinical features of renal cysts?
usually asymptomatic, but may have flank pain diagnosed through CT/MRI bosniak scoring serum u and e check
74
what is the management of renal cysts?
if symptomatic and simple - analgesia and maybe aspiration if symptomatic and cmplex - staging, surveillance and possible surgical intervention - nephrectomy ...can lead to infection, haemorrahge and rupture
75
what are the types of renal stones?
renal or ureteric stones made of calcium oxalate, calcium phosphate or mixed oxalate and phosphate, urate and cystine stones as well
76
what is the pathophysiology of renal tract calculi?
over saturation of urine urate - high levels of purine (from diet - red meats or blood disorders)---urate formation and crystallisation of urine cystine - homocystinuria, meaning less citrate...prediposes to stone formation
77
where are renal stones likely to lodge?
-pelviureteric junction - where iliac vessels travel across ureter in pelvis - vesicoureteric jjunction
78
what are the clinical features of renal caliculi?
ureteric colic pain (increased peristalysis from around site of obstruction), sudden onset and severe and radiating from flank to pelvis, N+V, haematuria, fever - tenderness in affected flank
79
give 3 differentials for renal caliculi
pyelonephritis, ruptured AAA, bowel obstruction
80
how is renal caliculi diagnosed?
urine dip - haematuria, infection FBC, CRP, UE, urate and calcium levels, retrieval of stone gold standard - non contrast CT scan of renal tract
81
how are renal caliculi managed?
adequate fluid resuscitation stones can pass spontaneously sufficient analgesia - opiate, NSAID per rectum IV abx if infection may require stent insertion or nephrostomy(place stent within ureter distal to proximal via cystoscopy) ESWL (shock waves), percutaneous nephrolithotomy, flexible uretero-renoscopy
82
what are bladder stones?
chronic urinary retention - stasis, or from infections drained through cystoscopy can predispose to development of bladder cancer
83
define pyelonephritis and the pathophysiology
inflammation of the kidney parenchyma and renal pelvis - usually due to bacteria either from ascending lower UTI, or directly from blood stream - sepsis or infective endocarditis...usually E.coli
84
what are the risk factors for pyelonephritis?
antegrade flow of urine - BPH, spinal cord injury retrograde ascent of bacteria - female, indwelling catheter, structural renal abnormalities factors predisposing/immunocompromised - DM, HIV, corticosteroid use bacterial colonisation - renal caliculi, sex, menopause (oestrogen depletion)
85
what are the clinical features of pyelonephritis?
fever, unilateral loin pain, N +V, lower UTI sx, haematuria, pyrexia, costovertebral angle tenderness ...should be checked for potentially ruptured AAA
86
which investigations are required for pyelonephritis?
urinalysis - nitrites, leukocytes, urinary beta hCG FBC, CRP, UE renal USS for suspected obstruction...then non contrast CT possible flexible cystoscopy
87
how is pyelonephritis managed?
ABX Fluid analgesia anti emetics possible catheterisation
88
what are the types of renal cancer?
renal cell carcinoma transitional cell carcinoma nephroblastoma squamous cell carcinoma
89
define renal cell carcinoma
adenocarcinoma of renal cortex...from PCT -direct spread into tissues - lymphatics - haematogenous spread
90
what are the risk factors for renal cell carcinoma?
smoking industrial exposure dialysis hypertension obesity anatomical abnormalities - polycystic and horseshoe
91
what are the clinical features of renal cell carcinoma?
haematuria flank pain and mass lethargy weight loss mass may be able to be palpated in flank, left sided masses with left varicoele due to compression of left testicular vein as joins renal paraneoplastic syndromes - ectopic secretion of hromones
92
what is the first line investigation for RCC?
CT scanning of abdomen-pelvis pre and post IV contrast
93
how is RCC staged?
american joint committee on cancer staging classification based on size
94
what is the management of RCC?
if smaller - partial nephrectomy or radical if larger (kidney, perinephric fat, local lymph nodes, adrenal glands) if not able to undergo surgery - percutaneous radiofrequency ablation or cryotherapy + surveillance + immunotherapy (not chemo)
95
what are the types of bladder cancer?
transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, sarcoma further subdivided - non muscle invasive, muscle invasive and metastatic
96
give 4 layers of the bladder wall
inner - urothelium second - lamina propria third - muscular propria fourth - connective tissue
97
give the risk factors for bladder cancer
smoking age industrial dyes or rubber schistosomiasis previous radiation
98
what are the clinical features of bladder cancer?
painless haematuria, recurrent UTI, LUTS, pelvic pain, weight loss
99
how is bladder cancer investigated?
flexible cystoscopy tumour - biopsy and transuretheral resection CT staging
100
how is bladder cancer managed?
non muscle invasive - resected, intravesical therapy, radial cystectomy possible muscle invase - radical cystectomy and neoadjuvant chemo ...can have bladder reconstruction metastatic - chemo
101
give 5 types of urinary incontinence
stress urge mixed overflow continuous
102
stress UI
intra abdominal pressure exceeds urethral pressure...due to usually weakness in pelvic floor muscles
103
urge UI
overactive bladder - destrusor hyperactivity - rise in intravesicular pressure...neurogenic,infectious or malignancy cause
104
mixed ui
stress + urge
105
overflow UI
complication of chronic UI - progressive stretching of bladder wall leads to damage...prostatic hyperplasia or spinal cord injury
106
continious UI
constant leakage..anatomical abnormality such as ectopic ureter or fistula
107
which investigations are required for UI?
midstream urine dipstick post void bladder scans urodynamic assessment- destrosumer muscle pressure calculated outflow dynnamics = detrusor muscle activity against urine flow rate
108
how is UI managed conservatively?
weight loss, reduce caffeine intake, avoid drinking excess, smoking cessation pelvic floor muscle training, duloxetine (SSRI) = stress anti muscarinics such as oxybutynin, bladder training = urge
109
what is the surgical management of UI?
urge - botulinum toxin A injections, sacral nerve stimulation stress - tension free vaginal tape, intramural bulking agents or artificial urinary sphincter
110
define prostatitis
inflammation of prostate gland can be acute or chronic (becomes chronic when not treated) usually caused by ascending urethral infection- e.coli but can also be STI's
111
what are the risk factors for acute bacterial prostatitis?
indwelling catheter, phimosis, recent surgery, immunocompromised for chronic - intraprostatic ductal reflex, dysfunctional bladder
112
what are the clinical features of prostatitis?
LUTS, pyrexia, perineal or suprapubic pain DRE - tedner prostate
113
how is prostatitis investigated?
uirne culture STI screen bloods - fbc, crp, u and e, psa if fail to respond to tx - prostate abscess suspscted so tranrectal prostatic USS
114
how is prostatitis treated?
prolonged abx - usually quinolone analgesia alpha blockers - tamsulosin possible urology referral and chronic pain specialist
115
what are the risk factors for BPH?
age family history black african or caribbean obesity
116
what are the clinical features of BPH?
LUTS - voiding sx haematuria haemtospermia DRE - firm, smooth, symmetrical prostate international prostate symptom score
117
how is BPH investigated?
urinary frequency and volume chart bedside urinalysis post void bladder scan PSA test USS of renal tract - volume of prostate urodynamic studies
118
how is BPH treated?
reassurance, sx diary, medication review alpha adrenoreceptors antagonist - tamsulosin 5 alpha reductase inhibitors - finasteride analgesia surgical - if high pressure retention - transurethral resection of prostate
119
what are the two types of prostate cancer?
acinar adenocarcinoma ductal adenocarcinoma
120
what are the risk factors of prostate cancer?
age men of black african or caribbean family history BRCA1/2 gene obesity smoking
121
what are the clinical features and investigations of prostate cancer?
LUTS haematuria, dysuria, incontinence, haemtospermia, suprapubic pain,loin pain, rectal tenesmus, lethargy, unexplained weight loss DRE - posterior peripheal zone - evidence of asymmetry, nodularity or fixed irregular mass mp-MRI and then a targeted biopsy
122
what is the reason for raised PSA
prostate cancer, BPH, prostatits, UTI, recent surgery, urinary retention
123
how is prostate cancer graded?
gleason
124
how is prostate cancer managed?
low risk - surveillance intermeidate - mostly surveillance metastatic - chemo and anti hormonal agents surgical - radial prostatectomy...can cause erectile dysfunction radiotherapy anti androgen therapy and chemo
125
define urethritis
inflammation of the urethra...gonococcal or non gonococcal (usually chamydia trachomatis or trichomonas vaginalis)
126
what are the clinical features of urethritis?
dysuria, penile irritation, discharge
127
give 2 complications of urethritis
epididymitis or reactive arthritis
128
define balanitis
inflammation of the glans penis, presents with pruritis, erythema and discharge between foreskin and glans..older patients
129
how is urethritis diagnosed?
first void urine sent for nucleic acid amplification test urethral gram stain under microscopy from urethral swabs mid stream urine dipstick
130
how is urethritis managed?
gonococcal - cefraxione IM single dose + azithroymycin PO single dose non gonococcal - doxycyline PO BD + azithromycin PO single dose no sexual activity for 7 days after abx have finished condom use notify sexual partners
131
what is the most common cancer in males aged 20-40?
testicular cancer
132
what are the types of testicular cancer?
germ cell tumour and non germ cell tumours germ cell - seminomas and non seminomatous (yolk sac, choriocarcinoma, embryonal carcinomas, teratoma) - worse prognosis non germ cell - leydig cell or sertoli cell - better prognosis
133
what are the risk factors for testicular cancer?
cryptochordism - germ cell tumours previous testicular malignancy family history caucasian ethnicity kleinfelter's syndrom
134
what are the clinical features of testicular cancer?
unilateral painless lump mass is ireegular, firm, fixed and not transilluminate weight loss back pain from retroperitoneal metastases dypnoea from lung metastases
135
what are the investigations for testicular cancer?
beta-hcg AFP LDH scrotal USS and then staged via CT with contrast staged via royal marsden classification
136
how is testicular cancer managed?
surgery - inguinal radical orchidectomy radiotherapy, chemo pre treatment fertility assessment
137
define epididymitis and age range
inflammation of epidiymis, bimodal age distribution
138
what is the pathophysiology of epidiymitis?
local extension of infection from lower urinary tract - UTI OR STI
139
what are the clinical features of epidiymitis?
unilateral scrotal pain and swelling with fever dysuria, storage LUTS, urethral discharge tender on palpation cremasteric reflex not intact and positive prehn's sign
140
which investigations are required for epidiymitis?
urine dipstick, first void urine for NAAT, routine bloods USS of testes via doppler
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
141
how is epididymtiis managed?
abx and analgesia bed rest and scrotal support abstain from sex condoms can result in reactive hydrocoele formation
142
define testicular torsion
spermatic cord twists WITHIN TUNICA VAGINALIS
143
which investigations are required for testicular torsion?
clinical diagnosis dopper can be used to see compromised blood flow urine dipstick - rule out
144
what is the management of testicular torsion?
within 4-6 hrs - bilateral orchidopexy or orchiodectomy if non viable testes analgesia anti emetics maintenance fluids
145
how is the diagnosis made for the cause of epidymitis?
Investigations for suspected epididymo-orchitis are guided by age: sexually active younger adults: NAAT for STIs older adults with a low-risk sexual history: MSSU
146
how is epididymitis treated?
Single dose ceftriaxone and 10-14 days of doxycycline
147
what are the sx requiring a radical nephrectomy?
Painless flank mass, haematuria, and paraneoplastic features including hypertension, polycythaemia, hypercalcaemia, and Cushing's syndrome.