Urology Drugs Flashcards
(41 cards)
Name a 5a reductase inhibitor
Finasteride
What is use of finasteride
Second-line agent in BPH
How do 5a reductase inhibitors work
Inhibits 5a reductase preventing conversion of testosterone to dihydrotestosterone = reducing size of prostate gland
Why are a-blockers preferred to finasteride
As 5a reductase inhibitors take several month to reduce size of prostate
What are 4 side effects due to androgen action of finasteride
- ED
- Decrease libido
- Abnormal hair growth
- Gynaecomastia
When is finasteride advantageous
Male baldness
What serious side effect of finasteride has been reported
Breast cancer in males
What is an absolute CI of finasteride and why
Pregnancy - will cause abnormality in genitalia of male infants
How is pregnant women’s exposure to finasteride avoided
Do not have unprotected sex with male taking finasteride
name 3 alpha-blockers
- Tamsulosin
- Doxazosin
- Alfuzosin
what a-receptor are alpha blockers selective for
a1-adrenoceptors
where are a1-receptors found
smooth muscle of blood vessels and urinary system
what side-effects are associated with a-blockers
- Postural Hypotension
- Dizziness
- Syncope
when are side effects of a-blockers worse
First-dose
what drug should be omitted when the first dose of a-blockers is given
B-blockers:
- as a-blockers cause vasodilation (postural hypotension)
- b-blockers would inhibit reflex tachycardia that forms part of compensatory response
when is the best time to take doxazosin and why
bedtime - due to postural hypotension effects
if a man has HTN and BPH what may you consider
introduce doxazosin (not tamsulosin as only licensed for BPH) earlier in HTN management
what is the role of aldosterone
Increases ENaC channels in the distal tubule increasing sodium reabsorption
what is the role of aldosterone antagonists
Aldosterone antagonists inhibit aldosterone causing sodium and water excretion and potassium retention
what is a serious adverse effect of aldosterone antagonists
Hyperkalaemia
how may hyperkalaemia present
Muscle weakness
Arrhythmias
what effect do patient’s complain of with aldosterone antagonists
Gynaecomastia
what can aldosterone antagonists do to the liver
Liver impairment - causing jaundice
what is a serious dermatological side effect of aldosterone antagonists
Steven Johnson Syndrome
