UTI

Question 1

TMP/SMX DF

Answer 1

Oral

Question 2

TMP/SMX spectru,

Answer 2

Aerobic enteric bacteria except P.aeru

Question 3

TMP/SMX use

Answer 3

Prophylaxis for recurrent

Question 4

Nitrofurantoin DF

Answer 4

Oral

Question 5

Nitrofurantoin use

Answer 5

Therapeutic & prophylaxis

Cystitis & recurrent

Question 6

Fosfomycin DF

Answer 6

Oral as single dose

Question 7

Fosfomycin use

Answer 7

Uncomplicated infection —> cystitis but not pyelonephritis

Question 8

UTI drugs with low resistance

Answer 8

Nitrofurantoin & fosfomycin

Question 9

FQ DF

Answer 9

Oral

IV

Question 10

FQ spectrum

Answer 10

Greater spectrum than others w/P.aeru

Question 11

FQ use

Answer 11

Pyelonephritis

Prostatitis

Question 12

FQ Cautions

Answer 12

1. Not in preg
2. Not in Children
3. Moxi not used due to lack of urinary conc

Question 13

Penicillin used in UTI & their DF

Answer 13

1. Amox-clav - oral
2. amp-sul - IV
3. Pip-tazo - IV

Question 14

Amox-clav use

Answer 14

Preferred penicillin for uncomplicated cystitis

Question 15

Amp-sul & pip-tazo spectrum

Answer 15

More act ag P.aeru and entero and are preferred over cephalosporins

Question 16

In which patients are Amp-sul & pip-tazo useful

Answer 16

1. Renally impaired pts

2. Amino glycoside is to be avoided

Question 17

Cefalexin
Cefaclor
Cefpodoxime-proxetil

Answer 17

Useful in cases of resistance

Not act ag entero

ORAL

Question 18

Ceftriaxone
Ceftazidime
Cefepime

Answer 18

Act ag p.aeru

IV

Question 19

Use of 3rd & 4th cephalosporins

Answer 19

Nosocomial infections

Urosepsis

Question 20

Carbapenems / monobactms DF

Answer 20

IV

Question 21

Carbapenems spectrum

Answer 21

Broad including gram positive / gram negative / anaerobic

P.aeru except ertapenem

Question 22

Aztreonam spectrum

Answer 22

gram-negative bacteria, including some strains of P.

aeruginosa .

Question 23

Aztreonam uses

Answer 23

Nosocomial infections when AG are to be avoided & in penicillin sens pts

Question 25

Aminoglycosides Gentamicin, Tobramycin, Amikacin DF

Answer 25

IV

Question 26

Acute simple cystitis treatment ?

Answer 26

1. Nitrofurantoin 2. TMP/SMX 3. trimethoprim 4. Fosfomycin

Question 27

Alternatives in acute simple cystitis

Answer 27

1. Amoxicillin/clavulanate 2 cephalosporins oral 3. FQ Duration longer bcz not as effective as 1st lines

Question 28

Recurrent infections?

Answer 28

Nitrofurantoin TMP/SMX 6 months

Question 29

Acute simple cystitis / asymptomatic bacteriuria (ASB) in pregnancy

Answer 29

``` 1 nitro Amox-clav Cephalexin Cefopodoxime Fosfo TMP/SMX ```

Question 30

What are the drugs avoided in 1st trimester?

Answer 30

Nitro & TMP/SMX

Question 31

Acute uncomp pyelo / acute comp cystitis

Answer 31

if out patient Floxacins If local FQ resistance is > 10%, give ceftriaxone 1 g IV once or a dose of an AG (pending culture results) Then alternatives: TMP/SMX Cefpodoxime Amox-clav Give ceftriaxone 1 g IV once or AG ``` Inpatient Floxacins Ceftriaxone Cefepime Pip-tazo ``` May add AG pending culture results.

Question 32

AG uses

Answer 32

Reserved for serious illness Amikacin reserved for multidrug resistance