Uveitis Flashcards

Question

Congenital Rubella Syndrome

Answer 1

The systemic manifestations of CRS are deafhess (most common systemic sign), cardiac malformations (e.g. patent ductus arteriosus). and ocular findings. Of the possible ocular findings, pigmentary retinopathy is the most common in CRS. Despite the striking appearance of the fundus, vision is not typically affected by this pigm^ntary retinopathy. Instead, poor vision in CRS is usually caused by cataract and microphthalmos. The classic teaching is that pataract and glaucoma do not occur simultaneously in CRS, The most common cause of poor vision in children with CRS are cataract and microphthalmos.

Answer 2

adolescent girl and young women of their early 30's, severe ant inflam with fibrin and PS, possible posterior inf such as vitritis and papilitis

Answer 3

Al - anterior lenticonus P- PSC O- Otic issue RT - renal issue

Answer 4

PORN (progressive outer retina necrosis): lack of inflammation and retinal hemorrhage. Tx- intravitreal + systemic ganciclovir or foscarnet (acyclovir is not adquate) CMV retinitis: oral valganciclovir for induction and maintenance

Answer 5

RF: tropical area with exposure of live stock incubation 1 mo acute phase: fever, chills, nausea, vomit, diarrhea, muscle ache; then severe liver and renal failure Eye sign: circumcorneal conjunctival injection and congestion Can cause FALSE POSITIVE rpr and FTA-ABS syphilis test

Answer 6

Type V immune reactions are also known as "stimulatory hypersensitlvity" reactions. They are a more-recently classified type of hypersensitivity reaction. These reactions involve antibodies that react with specific cell surface receptors and either depress or stimulate cell function. Examples of type V reactions are thyroid eye disease (i.e. Graves disease) and myasthenia gravis. Type V is used to distinguish immune reactions from type II since in type V, the antibodies bind to cell surface receptors (and not just to any cell surface components as in type It). Type I immune reactions are anaphylactic or atopic reactions. In these reactions, pre-formed IgE antibodies bound on mast cell receptors react with the offending antigen. This binding causes degranulation of the mast cell with subsequent histamine release. An example of a Type I reaction is allergic or atopic conjunctivitis. Type II immune reactions are cytotoxic. This reaction occurs when antibodies bind to foreign antigens and activate the complement pathway. An example of a type II reactiey is ocutar cicatricial pemphigoid. Type III immune reactions are also known as "jmmune-complex reactions." These reactions result from immune complex deposition in tissues which activate the complement and other effector systems. Examples of Type III reactions are Stevens-Johnson syndrome and scleritis. Type IV immune reactions are delayed hypersensitivity reactions. These involve recruitment of pre-sensitized immune cells. Examples of a type IV reaction are contact dermatitis and a positive PPD reaction. Note that unlike the other hypersensitivily reactions, type IV reactions are NOT antibody-mediated. Type IV reactions are cell-mediated instead.

Answer 7

HLA-B54 (VKH and SO also HLA-DR4) Birdshot - HLA-A29 Behcet's HLA-B51

Answer 8

present before 1, skin yellow-brown nodule, and yellowish iris mass with spontaneous hyphen -- Touton giant cell vs Langerhan's giant cell - horseshoe nuclei - sarcoidosis and TB

Answer 9

HLA-B27 + vs HLA-B27 neg plus no sacroiliitis

Answer 10

Herpes Fuchs Toxo CMV (hypopion assoc with non-endophahalmitis uveitis: HLA-B27 and Adamantiades-Behcet's

Answer 11

med treatment for CMV retinitis -- but 10 fold increase risk to develop IRU (immune recovery uveitis - ant and intermediate uveitis and CME) Also, increase risk for idiopathic ant uveitis and hypotony, tx with steroid, if response no need to stop meds.

Answer 12

Whipple disease | - caused by actinomycetes bact --> Tropheryma Whipplei - duodenal bx shows PAS positive bact in Macrophage.

Answer 13

Th1: IL-2, IL-12, IFN-gamma, TNF-beta; help B cells produce Ig-G, and inhibits Th2 Th2: IL-4,5,10; help B cells produce IgA and IgE; inhibit Th1 cells

Answer 14

HLA-B27 neg without sacroiliitis vs HLA-B27 pos with sacroiliitis

Answer 15

POHS, PIC (punctate inner choroiditis) Also PORT (punctate Outer Retinal Toxoplasmosis) SSPE, and serpiginous

Answer 16

3C's: cough, coryza (running nose) and conjunctivitis Then rash from head to toe Then Measles retinopathy: retinal edema, optic disc edema, intraretnal hemorrhage, and macular scar. Once subsides, pigmentary retinopathy, resemble RP (bone spicules) or rubella (salt-and-pepper), resulting permanent visual field constriction.

Answer 17

- Rifabutin, DEC, OCP, biphosphonates, sulfonamides CAUSE - Metipranolol, travaprosst associated - PPD, influenza, BCG vaccines also

Answer 18

both macular and chorioretinal peripheral scarring, | but more diffuse intracerebral calcifications compared to a periventricular distribution in congenital LCMV disease

Answer 19

750 microns

Answer 20

Uveitis + constitutional signs: fever, parotid gland swelling, facial nerve palsy vs Uveitis+ signs: fever, b/l hilar adenopathy, erythema nodosum, arthropathy

Answer 21

Fuchs', sarcoid, herpes

Answer 22

Fuchs', Posner-Shlossman HSV, VZV Toxo, pars planitis

Answer 23

HLA-B27, endophthalmitis, Behcet | Rifabutin, malignancy

Answer 24

Phlebitis: sarcoidosis, MS, Birdshot, Eales Arteritis: ARN, PAN, SLE, Susac (retinocochleocerebral antipathy) Both: Behcet, too

Answer 25

cat scratch disease, IRVAN (idiopathic retinal vasculitis, aneurysms and neuroretinitis), DUSN CRVO!

Answer 26

``` Focal: Vit cells: Toxocariasis No. Vit cells: serginginous, tumor Multifocal: Vit cells: most White dots, VKH, SO No vit cells: OHS, PIC, Krill ```

Answer 27

``` Sarcoid, TB VKH, SO Behcet's Syphilis always bilateral, non-idiopathic, granumatous (exp Behcet) ```

Uveitis Flashcards

(51 cards)