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Flashcards in Uveitis Vol. 1 Deck (27):
1

What are the two main physiologic changes that occur within a tissue in response to inflammation?

Cellular recruitment and altered vascular permeability

2

What is the most abundant type of granulocytes found in the blood?

Neutrophils

3

What cytokine is especially important in the recruitment of eosinophil?

IL-5

4

What type of leukocyte is important mediator of parasitic infections?

Eosinophils

5

What is the blood borne equivalent of tissue-bound mast cells?

Basophils

6

What type of leukocyte does the cornea NOT contain?

Mast cells

7

Where are Kupper cell macrophages located?

Liver

8

What type of cells is associated with Birbeck granules?

Langerhans cells

9

What are the only type m cells that express class II MHC in the conjunctiva and limbus?

Langerhans cells

10

Where do T-cells mature?

Thymus

11

Where do mature, naive lymphocytes reside awaiting exposure to antigens?

Lymph nodes

12

What is the antigen presenting complex of CD4, or helper T-cells?

Class II MHC

13

What is the antigen presenting complex of CD8, or regulatory T-cells?

Class I MHC

14

What is an epitope?

Specific region of an antigen that is recognized by the immune system

15

What is a paratope?

Epitope-specific binding site of the Fab portion of the antibody

16

What is the primary cytokine released by CD4 T-cells in response to activation?

IL-2

17

What cytokine released by Th1 calls inhibits Th2 calls?

INF-gamma

18

What cytokine released by Th2 calls inhibits Th1 calls?

IL-4

19

What type of macrophages are found within the retina?

Microglial macrophages

20

What type of immunoglobulins are found in the choroid?

lgG and lgA

21

Name 3 characteristics of the cornea that lead to "immune privilege."

1. Fas ligand 2. Avascularity 3. Lack of central APC

22

What is the most important immunoregulatory system of the conjunctiva?

Mucosa-associated lymphoid tissue (MALT)

23

What is the two primary antibodies form by the MALT system?

lgA and lgE

24

What is the primary type of helper T-cell of the MALT system?

Th2

25

What type of collagen is found in the vitreous?

Type II collagen

26

What is the primary characteristic of anterior chamber-associated immune deviation (ACAID)?

Robust systemic antibody response but absence of delayed hypersensitivity response

27

What is primary function of Fas ligand?

Apoptosis of effector T-cells