uworld1 Flashcards

1
Q

how are bpp scores evaluated?

A

8/10 = L
6/10 = equivocal
< 4 = deliver

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2
Q

what is def. of oligohydramnios?

A

AFI < 5 cm

deepest vertical pocket < 2 cm

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3
Q

what is def. of polyhydramnios?

A

AFI > 24 cm

deepest vertical pocket > 8 cm

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4
Q

in metabolic compromise, what is order of abnormalities?

A

HR decels
absent fetal breathing
dec. body mov’t / tone

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5
Q

which macrolide may cause acute cholestatic hepatitis in preegnancy?

A

erythromycin

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6
Q

what is a nL NST?

A

> 2 accelerations in 20 min

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7
Q

what is abnl NST?

A

< 2 accels

recurrent variable / late decels

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8
Q

contraction stress test

A

external FHR w/ spontaneous / induced uterine contractions (oxytocin/nipple stimulation)

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9
Q

nL CST result

A

no late recurrent variable decels

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10
Q

abnl CST

A

late decles in > 50% of contractions

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11
Q

what do late decels mean?

A

uteroplacental insufficiency

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12
Q

umbilical artery doppler velocimetry

A

used for IUGR
nL = high velocity, diastolic low in umbilca artery
abnl = dec, absent, reversed end diastolic flow

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13
Q

what meds cause a non reactive NST?

A

mgSO4, narcotics, steroids

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14
Q

meaning of nL CST results

A

no late / recurrent variable decles –> low likelihood of stillbirth 1/1000 w/in 1 wk

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15
Q

unsatisfacotry CST?

A

< 3 contractions of 40 seconds in 10 min

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16
Q

unequivocal CST?

A

recurrent variable decels
intermittent late decels
decels on contractions > 90 s of q2 min

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17
Q

systemic effects of tamoxifene?

A

dec. osteoporosis

incr. risk of endometrial cancer

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18
Q

hormone profile of turner’s?

A

incr. FSH, low E

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19
Q

bilateral renal agenesis fetus prognosis?

A

will die

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20
Q

what is contraindicated w/ endometrial hyperplasia?

A

endometrial ablation contraindicated

prevents future eval by biopsies

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21
Q

how to treat hyperplasia w/o atypia?

A

3% chance of cancer
treat w/ progestin
repeat biopsy in 3 mo to assess response

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22
Q

how to treat hyperplasia w/ atypia?

A

1) hysterectomy

2) future pregnancy

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23
Q

lichen sclerosis progresses to?

A

squamous cell carcinoma of the vulvar

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24
Q

treatment for lichen sclerosis?

A

chronic inflammatory condition - vulvar itching + flaking
treatment: high-potency topical steroids (twice daily, 4 wks) –> less potent topical steroid / topical calcineurin inhibitor

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25
Q

radical vulvectomy, when is it used?

A

invasive squamous cell carcinoma / melanoma

if basal cell carcinoma / = less disfiguring

26
Q

what is pathophysiology of pre-eclampsia?

A

placental endothelial cell dysfunction / vasospasm

27
Q

what are drawbacks of methyldopa in pregnancy for acute HTN episodes?

A

slow onset

sedating

28
Q

nitroprusside + HTN crisis?

A

last resort: cyanide = byproduct

29
Q

effect of hyperglycemia on fetus (mechanism)

A

hyperinsulinemia –> fetal hypoxia –> incr. erythropoiesis –> polycythemia –> ischemia/infarction

30
Q

effects of hyperglycemia on fetus post partum (lab values)

A

hypocalcemia (PTH suppression)
hypoglycemia
hyperbilirubinemia
polycythemia

31
Q

features of severe pre-eclampsia

A
BP > 160/110
thrombocytopenia < 100K
serum creatinine > 1.1 
elevated transaminases
pulmonary edema
new onset visual/cerebral symptoms
32
Q

how does pregnancy incr. the likelihood of carpal tunnel?

A

estrogen –> incr. interstitial edema –> incr. carpal tunnel pressure

33
Q

what are features suggesting malignant discharge?

A

unilateral
bloody/serous
palpable skin changes

34
Q

what are the lab derangements in hyperemesis gravidarum?

A

hypokalemia, ketonuria

35
Q

clinical presentation of hyperemesis gravidarium?

A

severe, persistent vomiting
ketonuria
>5% loss of pre-pregnancy weight

36
Q

what is treatment for hyperemesis gravidarum?

A

hydration
ginger
pyridoxine +/- doxylamine

37
Q

what are risk factors for hyperemesis gravidarium (when does it present)

A

multifetal gestation / molar pregnancy

incr. placental mass –> highest hcg @ 10-12 wks (true for all women)

38
Q

what are causes of elevated maternal serum AFP?

A

produced by: fetal yolk sac, liver, GI tract
open neural tube defects
fetal abdominal wall defects (gastroschisis / omphalocele)
multiple gestation
fetal congenital nephrosis + benign obstructive uropathy

39
Q

what are some treatments for urge incontinence?

A

oxybutynin - anticholinergic

40
Q

for what type of incontinence is urethropexy used?

A

stress

41
Q

early decel - visual finding + etiology?

A

symmetric to contraction
gradual (> 30s from nadir to onset)
fetal head compression (possibly normal)

42
Q

late decel - visual finding + etiology?

A

occurs after contraction

cause: uteroplacental insufficiency

43
Q

variable decel - visual?

A

not necessarily assoc. w/ contractions
abrupt (< 30s from nadir)
(duration > 15 s, < 2 min)

44
Q

variable decel etiology

A

cord compression
oligohydrmanios
cord prolapse

45
Q

med treatment for acute abnL uterine bleeding?

A
high dose IV/oral estrogen
high dose combined OCP
high-dose progestin (if E contraindication)
tranexamic acid (if both P/E contraindicated)
46
Q

what is mechanism of high E for acute uterine bleeding?

A

rapidly regrow endometrium from prolonged heavy bleeding

47
Q

fetal hydantoin syndrome

A

midfacial hypoplasia, microcephaly, cleft lip/palate, digital hypoplasia, hirsuitism, dev’t delay

48
Q

signs of congenital syphilis

A

rhinitis (snuffles) + skin lesions

later: keratitis, hutchinson, saddle nose, deafness

49
Q

fetal hydantoin syndrome vs. fetal alcohol syndrome

A

fetal alcohol doesn’t have cleft palate / excess hair

50
Q

where does placental abruption occur?

A

bleeding b/w decidua & placental interface –> placental detachment –> no exchange to fetus

51
Q

how to manage placental abruption?

A
  • IV access

- if stable vitals + > 37 wks –> vaginal delivery (maybe w/ oxytocin augmentation)

52
Q

what must be r/o w/ placental abruption?

A

placental previa

53
Q

how does ABO incompatibility occur & how does it present?

A

group O mother w/ a group A / B
mild anemia / neonatal jaundice - treatable w/ phototherapy
milder response than Rh(D) incompatibility

54
Q

what is treatment for adenomyosis?

A

hysterectomy

no other options

55
Q

molar pregnancy progression to choriocarcinoma

A

20%

56
Q

molar pregnancy + ovary findings

A

theca lutein cysts

57
Q

pregnancy markers

A

progesterone > 25

58
Q

betamethasone what do you use it for?

A
  • fetal lung maturity
  • prevents respiratory
  • prevents intercerebral hemorrhage
  • nec. entero
59
Q

when is Mg contraindicated

A

Myasthenia gravis -

poor renal function

60
Q

nL endometrial thickness post menopausal

A

<5mm

61
Q

when might IUDs be contraindicated?

A

in a fibroid uterus with changes to the cavity (i.e.: submucosal fibroids

62
Q

what are absolute contraindications to estrogen OCP?

A

DVT, PE, cardiovascular disease, stroke, breast/endometrial cancer, melanoma, hepatic tumor, abnL liver fuxn